Effect of amino acids on the stability of spray freeze-dried immunoglobulin G in sugar-based matrices

Emami, Fakhrossadat; Vatanara, Alireza; Najafabadi, Abdolhosein Rouholamini; Kim, Yejin; Park, Eun Ji; Sardari, Soroush; Na, Dong Hee

doi:10.1016/j.ejps.2018.04.013

Cited by 28 publications

(21 citation statements)

References 31 publications

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“…Atmospheric freezing, spray freezing with compressed carbon dioxide, spray freezing into a vapor over a cryogenic liquid, and spray freezing into a liquid are different types of SFD methods [ 50 , 51 , 52 ]. SFD involves the atomization of protein solution via a nozzle at extremely low temperatures, and has potential applications for thermo-labile active pharmaceutical ingredients.…”

Section: Drying Techniquesmentioning

confidence: 99%

“…These observations suggest that superior aerodynamic behavior by SFD particles is probably correlated with small aerodynamic size. Consequently, SFD powders, in comparison with SD powders, are reported to possess higher FPF and lower aerodynamic diameter, which result in higher aerosolization efficiency [ 52 ]. Because of rapid evaporation of water in the drying chamber, SD particles had smaller sizes resulting from particle shrinkage.…”

Section: Drying Techniquesmentioning

confidence: 99%

“… Scanning electron micrographs of dried IgG formulations produced using different drying methods: ( a ) SD [ 42 ], ( b ) SFD [ 52 ], and ( c ) SCFD methods [ 66 ]. …”

Section: Figurementioning

confidence: 99%

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Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

et al. 2018

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Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide enhanced bioavailability, improved storage stability, as well as expanded alternatives to parenteral administration. Although numerous drying methods have been used for preparing dried protein powders, choosing a suitable drying technique remains a challenge. In this review, the most frequent drying methods, such as freeze drying, spray drying, spray freeze drying, and supercritical fluid drying, for improving the stability and bioavailability of therapeutic proteins, are discussed. These technologies can prepare protein formulations for different applications as they produce particles with different sizes and morphologies. Proper drying methods are chosen, and the critical process parameters are optimized based on the proposed route of drug administration and the required pharmacokinetics. In an optimized drying procedure, the screening of formulations according to their protein properties is performed to prepare a stable protein formulation for various delivery systems, including pulmonary, nasal, and sustained-release applications.

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Section: Drying Techniquesmentioning

confidence: 99%

Section: Drying Techniquesmentioning

confidence: 99%

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Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

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“…2). Each process has its advantages as well as limitations (Campardelli et al 2016;Emami et al 2018a).…”

Section: Preparation Of Inhalable Pla/plga Particlesmentioning

confidence: 99%

Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

Emami

Yazdi

2019

J. Pharm. Investig.

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Background Pulmonary route is an attractive target for both systemic and local drug delivery, with the advantages of a large surface area, rich blood supply, and absence of first-pass metabolism. Numerous polymeric micro/nanoparticles have been designed and studied for controlled and targeted drug delivery to the lung. Area covered Among the natural and synthetic polymers for polymeric particles, poly(lactic acid) (PLA) and poly(lacticco-glycolic acid) (PLGA) have been widely used for the delivery of anti-cancer agents, anti-inflammatory drugs, vaccines, peptides, and proteins because of their highly biocompatible and biodegradable properties. This review focuses on the characteristics of PLA/PLGA particles as carriers of drugs for efficient delivery to the lung. Furthermore, the manufacturing techniques of the polymeric particles, and their applications for inhalation therapy were discussed. Expert opinion Compared to other carriers including liposomes, PLA/PLGA particles present a high structural integrity providing enhanced stability, higher drug loading, and prolonged drug release. Adequately designed and engineered polymeric particles can contribute to a desirable pulmonary drug delivery characterized by a sustained drug release, prolonged drug action, reduction in the therapeutic dose, and improved patient compliance.

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“…The formation of spherical particles in SFD additionally benefits the powder handling in the applications of drug delivery, particularly through the nasal route. [50] There are few variants in SFD and these are very well described by Emami et al [51] and Rogers et al [52] . These includes the use of compressed carbon dioxide in spray freezing, atmospheric freezing and spray freezing in head space of cryogenic liquid and so on.…”

Section: Spray Freeze Drying (Sfd)mentioning

confidence: 83%

Drying of Vaccines and Biomolecules

2020

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Vaccines are the most important life-saving prophylactic medicines administered in maintaining global health. In a pandemic situation, the manufacturing, formulation followed by preservation of vaccine are challenging areas of concern looking at the dire need of administering it to several billion people on the planet in a pandemic like situation. An important area of major concern is the potential loss of vaccine activity during storage and transportation. Scientists have developed several innovative ideas to store vaccines for a longer period of time. This article focuses on a critical overview of various methods of vaccine storage in dry powder form. Conventional vaccine drying processes, such as freeze drying under different conditions, spray drying along with the upcoming novel technologies such as spray freeze drying are described in detail for the application in vaccine drying. Some other emerging methods, such as, microwave freeze drying and atmospheric freeze drying techniques are also discussed; these could be the game changers in the future. Several drying techniques make use of protective agents during the process of drying and storage. This review also highlights a comparative study of various technological challenges in drying of vaccines in support of the current global health scenario affected by COVID19.

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Effect of amino acids on the stability of spray freeze-dried immunoglobulin G in sugar-based matrices

Cited by 28 publications

References 31 publications

Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

Drying of Vaccines and Biomolecules

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