Effect of ambient air PM2.5-bound heavy metals on blood metal(loid)s and children’s asthma and allergy pro-inflammatory (IgE, IL-4 and IL-13) biomarkers

Zahedi, Amir; Hassanvand, Mohammad Sadegh; Jaafarzadeh, Neemat; Ghadiri, Ata; Shamsipour, Mansour; Dehcheshmeh, Mohammad Ghasemi

doi:10.1016/j.jtemb.2021.126826

Cited by 27 publications

(10 citation statements)

References 53 publications

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“…These results strongly suggest that Hg activated a Th2 mediated signal transduction. IL-13 increases had been previously reported in children exposed through inhalation to fine particles carrying bound heavy metals (Zahedi et al, 2021). In this study, a correlation between blood Hg and IL-13 levels was detected (β = 8.0, p < 0.001).…”

Section: Hg Treatments Muc5ac Il-13supporting

confidence: 73%

Mercury toxic effects on the intestinal mucosa assayed on a bicameral in vitro model: Possible role of inflammatory response and oxidative stress

Rodríguez-Viso

Domene

Vélez

et al. 2022

Food and Chemical Toxicology

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Section: Hg Treatments Muc5ac Il-13supporting

confidence: 73%

Mercury toxic effects on the intestinal mucosa assayed on a bicameral in vitro model: Possible role of inflammatory response and oxidative stress

Rodríguez-Viso

Domene

Vélez

et al. 2022

Food and Chemical Toxicology

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“…However, oral and intratracheal administration of RL significantly reduced the levels of Th2-induced cytokines and the pro-inflammatory cytokine TNF-α in the blood, which were increased by WPM. In addition, it has been proven that as the concentration of heavy metals in the blood increases due to exposure to heavy metals, the concentration of IgE in the blood increases, which increases the severity of asthma, bronchial hypersensitivity, and the risk of allergic asthma by constricting smooth muscles ( Wang et al, 2017 ; Wu et al, 2019 ; Zahedi et al, 2021 ). Our data showed that the serum IgE concentration was further increased by WPM.…”

Section: Discussionmentioning

confidence: 99%

Rosa laevigata Attenuates Allergic Asthma Exacerbated by Water-Soluble PM by Downregulating the MAPK Pathway

Choi

Jee

et al. 2022

Front. Pharmacol.

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Exposure to water-soluble particulate matter (WPM) containing heavy metals can cause severe inflammatory responses and trigger and exacerbate the onset of asthma. As a follow-up study of Rosa laevigata (RL), this study analyzed the therapeutic effects and mechanisms of oral and intratracheal administration of RL and demonstrated anti-inflammatory effects in asthma models. Worse T-helper cell type 2 (Th2)-related inflammatory and pro-inflammatory responses were observed after simultaneous challenge with ovalbumin (OVA) and WPM. To establish a model of asthma exacerbated by WPM, BALB/c mice were sensitized with OVA + aluminum hydroxide and challenged with OVA + WPM. To confirm the therapeutic efficacy of RL, it was administered both orally and intratracheally. Histopathological analysis of H&E staining confirmed that oral and intratracheal administration of RL alleviated inflammatory cell infiltration in the airways aggravated by OVA + WPM. RL effectively reduced the number of inflammatory cells obtained from the bronchoalveolar lavage fluid. In addition, enzyme-linked immunosorbent assay (ELISA) and multiplex analysis of serum samples confirmed that the administration of RL reduced the levels of immuno-globulin E (IgE), Th2-related cytokines, and pro-inflammatory cytokines. Furthermore, real-time PCR analysis of lung tissue samples confirmed that the release of MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) and pro-inflammatory cytokines was reduced by RL, and western blotting confirmed that the administration of RL reduced the phosphorylation of ERK and p38 in the MAPK pathway. In conclusion, oral and intratracheal administration of RL appears to have an anti-asthmatic effect by reducing the secretion of Th2-related cytokines, pro-inflammatory cytokines, and IgE by downregulating the MAPK pathway. Thus, RL has further demonstrated potential for development as an oral and inhaled therapeutic for asthma symptoms exacerbated by WPM exposure.

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“…IgE is an antibody produced by the immune system, which causes allergic reactions in the nose, lungs, throat, and skin (Zahedi et al, 2021). The overproduction of IgE generally causes allergy in response to common environmental antigens.…”

Section: Discussionmentioning

confidence: 99%

Allergic inflammatory responses induced by traffic-related PM2.5 in BALB/c mice

Wei

Zhang

et al. 2021

Preprint

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Previous studies have shown that PM2.5 is associated with airway inflammation and lung injury. However, the association between traffic-related PM2.5 (TR-PM) exposure and OVA-induced allergic inflammation is not fully elucidated. In this study, we assessed allergic inflammatory responses of mice induced by TR-PM. PM2.5 was collected from a roadside with heavy traffic, and its soluble extract was prepared. Mice were treated with OVA, TR-PM alone, and OVA + TR-PM. The inflammatory cells were counted, and inflammation-related cytokines IL-4, IL-17A, and IL-10 in bronchoalveolar lavage fluid (BALF) were determined by the radioimmunity assay. Allergy-induced inflammation and lung injury were investigated by histopathological analyses. The expression of IL-4, IL-17A, and IL-10 mRNA was analyzed by RT-PCR. Our results revealed that TR-PM exposure, combined with OVA allergen sensitization, increased the inflammatory cells in BALF as well as levels of IgE in lung tissue; increased the IL-4 and IL-17A levels in BALF significantly, but decreased IL-10 level. The histopathologic results demonstrated that TR-PM markedly exacerbated the OVA-induced neutrophilic granulocyte, lymphocyte, and macrophage infiltration. Furthermore, the expression of IL-4, IL-17A and IL-10 mRNA was well in agreement with the results of the inflammatory cytokines. In conclusion, during the sensitization to allergic antigens, TR-PM exposure triggers severe allergic inflammation and lung injury. These findings suggest that commuters should use public transportation instead of riding motorcycles or walking during rush hours.

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Effect of ambient air PM2.5-bound heavy metals on blood metal(loid)s and children’s asthma and allergy pro-inflammatory (IgE, IL-4 and IL-13) biomarkers

Cited by 27 publications

References 53 publications

Mercury toxic effects on the intestinal mucosa assayed on a bicameral in vitro model: Possible role of inflammatory response and oxidative stress

Mercury toxic effects on the intestinal mucosa assayed on a bicameral in vitro model: Possible role of inflammatory response and oxidative stress

Rosa laevigata Attenuates Allergic Asthma Exacerbated by Water-Soluble PM by Downregulating the MAPK Pathway

Allergic inflammatory responses induced by traffic-related PM2.5 in BALB/c mice

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