Effect of aluminum on regional brain antioxidant defense status in Wistar rats

Abstract

This investigation gives a detailed analysis of oxidative stress conditions generated following chronic aluminum exposure (10 mg Al/kg body weight per day) for a period of 4 weeks. We observed a significant enhancement in the levels of lipid peroxidation at the completion of aluminium treatment. The antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase were seen to decrease following aluminum exposure. A significant decrease in the nonprotein sulfhydryl (NPSH) group status was also observed along with a decreased NPSH:disulfide ratio, thus further accentuating the oxidative insult to tissue. In vitro addition of desferrioxamine was shown to reverse aluminum induced lipid peroxidation, suggesting the probable therapeutic role of the drug against aluminum neurotoxicity.

Analysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administration

“…The observation that i.p. administration of aluminium predominantly accumulates in the hippocampus is in accordance with a previous work [20]. Our present study makes the interesting point that, while oral administration of aluminium chloride resulted in a significant increase of the metal concentration in the ventral midbrain, i.p.…”

“…aluminium chloride exposure for 1 week also caused a significant and greater aluminium accumulation in cerebellum, cortex, hippocampus, and striatum, a finding that is consistent with previous literature concerning particular brain areas [17][18][19][20]. However, most of these publications used extensive cerebral regions.…”

Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potential effects in a 6‐OHDA‐induced model of Parkinson’s disease

“…2005; Nehru and Anand 2005; Dua and Gill 2001; Jyoti et al. 2007) or partial agreement (Julka and Gill 1996) with most previously published data. Curiously, we found no significant changes in the levels of TBARS in the hippocampus.…”

“…2002), thus considering the latter as the main targets of the oxidant‐mediated damage. Furthermore, aluminium appears to affect the brain activities of several antioxidant enzymes (Julka and Gill 1996). In addition, its ability to affect the expression of dopamine (DA) receptors D 1 and D2 (Kim et al.…”

Protective Role of Cynodon dactylon in Ameliorating the Aluminium-Induced Neurotoxicity in Rat Brain Regions

“…The control group received tap water which was freely available. Groups II, III, and IV were exposed to aluminium chloride 4.2 mg/kg intraperitoneally [22] for 28 days. Groups III and IV rats were administered with the AECD suspension orally 1 h prior to the AlCl 3 induction for 28 days.…”