Effect of aluminum hydroxide on fluoride metabolism

Spencer, Herta; Kramer, Lois; Norris, C; Wiatrowski, Emilie

doi:10.1038/clpt.1980.198

Cited by 25 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…Numerous studies showed that aluminium could inhibit fluoride absorption (Spencer et al, 1980;Allain et al, 1996). A study conducted by Spencer and Kramer showed that intake of small doses of Al(OH) 3 increased urinary fluoride excretion and reduced fluoride absorption in the blood (Spencer & Kramer, 1985).…”

Section: Influence Of Al 3+ On Accumulation and Permeability Of Fluoridementioning

confidence: 99%

Tea components influencing bioavailability of fluoride and potential transport mechanism in the Caco‐2 cell line model

Peng

Sun

et al. 2020

Int J of Food Sci Tech

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Summary Previous work showed that the bioavailability of fluoride in dark tea was lower than NaF solution. However, limited information is available indicating the effects of tea components on the fluoride bioavailability. In this study, the effects of the components in tea on the bioavailability of fluoride were evaluated in the Caco‐2 cell line model. Additionally, the mechanism of effect of aluminium on fluoride transport was investigated. The result showed that 10–100 μm of epigallocatechin gallate (EGCG) could not influence fluoride transport. Al3+ significantly decreased fluoride transport in both apical‐basolateral and basolateral‐apical directions. Moreover, aluminium could form different forms of aluminium fluoride complexes, which were transported through Caco‐2 cells by different pathways. F− transport was mainly dependent on the paracellular pathway and active transport involving Cl− channels. The paracellular pathway played a predominant role in transport of AlF3. The paracellular pathway and active transport both participated in AlF2+ transport.

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Section: Influence Of Al 3+ On Accumulation and Permeability Of Fluoridementioning

confidence: 99%

Tea components influencing bioavailability of fluoride and potential transport mechanism in the Caco‐2 cell line model

Peng

Sun

et al. 2020

Int J of Food Sci Tech

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“…Existen estudios in vivo que evidencian que la biodisponibilidad de fluoruro está altamente influenciada por la composición de los alimentos ingeridos. Así, la biodisponibilidad de NaF en humanos disminuye si existe una administración simultánea de leche (Trautner y Einwag, 1989) Spencer, 1980b;Cerklewski, 1987;Tsuchida y col., 1992). Todo lo anterior indica que en los estudios in vitro donde se evalúa la bioaccesibilidad y la biodisponibilidad de fluoruro es necesario ensayar no sólo el alimento que contiene el fluoruro, si no cualquier alimento, tanto sólido como líquido, ingerido simultáneamente.…”

Section: Discussionunclassified

Fluoruro en alimentos: contenidos, bioaccesibilidad y absorción por el epitelio intestinal.

Barrasa¹

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A single‐dose comparison of the bioavailabilty of aluminium from two formulations of sucralphate in normal volunteers

Conway

O’Callaghan

Drummer

et al. 1994

Biopharm & Drug Disp

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The oral bioavailability of aluminium was compared after administration of 1 g sucralphate as either a tablet or a suspension (1 g/5 ml) in a crossover study in 16 healthy volunteers. Aluminium levels were detectable in all subjects pre-dose (21.4 +/- 8.8 micrograms l-1 before tablet; 21.4 +/- 7.4 micrograms l-1 before suspension) and there was a measurable increase in the plasma concentrations of aluminium in all subjects after administration of the suspension, and in 14 of the subjects after administration of the tablet formulation, with Cmax reached within the first 8 h in most subjects. Plasma levels were still elevated 72 h after dosing. The variability in plasma levels of aluminium was significantly higher after administration of the suspension (CV 39-53%) than after administration of the tablet (CV 29-44%), reflecting greater absorption of aluminium from the suspension formulation in three subjects. Similarly, the variance of the Cmax, AUC(0-72 h), and AUC(0-infinity) (for both the raw data and the baseline adjusted data) were all higher for the suspension than for the tablet. A point estimate of the difference of the pharmacokinetic parameters (determined from the median of the arithmetic Walsh averages) indicated little or no difference in Cmax, Tmax, or AUC(0-infinity) in the two formulations. In summary, the performance of the suspension formulation of sucralphate is more variable than the tablet formulation in vivo and some patients may therefore have higher circulating levels of aluminium on therapy with the suspension formulation.

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Effect of aluminum hydroxide on fluoride metabolism

Cited by 25 publications

References 6 publications

Tea components influencing bioavailability of fluoride and potential transport mechanism in the Caco‐2 cell line model

Tea components influencing bioavailability of fluoride and potential transport mechanism in the Caco‐2 cell line model

Fluoruro en alimentos: contenidos, bioaccesibilidad y absorción por el epitelio intestinal.

A single‐dose comparison of the bioavailabilty of aluminium from two formulations of sucralphate in normal volunteers

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