Effect of Alterations in Side Chain upon Anti-inflammatory and Liver Glycogen Activities of Hydrocortisone Esters**Merck Institute for Therapeutic Research, West Point, Pa.

In vivo analgesic, anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic fruits extract from Daemonorops robusta Warb

“…It has been postulated that MB induces antinociceptive effect by inhibiting peripheral sGC and NO. As pre-treatment with MB and subsequent administration of MEDR at all doses increased antinociceptive activity in acetic acid induced writhing model in mice than the groups where only MEDR were administered, it is quite clear that the antinociceptive action of MEDR involves the NO-cGMP pathway (Abacioglu et al, 2000;Xu et al, 1995). Our present study also demonstrated that glibenclamide, an ATP-sensitive K+ channel antagonist, partly reversed the antinociceptive activity shown by MEDR.…”

“…Physiological functions such as analgesia are greatly influenced by the cellular level of cGMP maintained by the action of soluble guanylylcyclase (sGC) mediated by nitric oxide (NO) (Abacioglu et al, 2000). It has been described that the function of cGMP on the ion channel depends on the activation of protein kinases and phosphodiesterases (Xu et al, 1995). The activation or deactivation of nociresponsive neurons are regulated by intracellular cGMP.…”

“…The administration of extract and drugs was 30 min prior to injection of 0.1 mL of 1% freshly prepared suspension of carrageenan in normal saline in the right hind paw sub plantar of each rat. The paw volume was MEDR used initially and then at ½, 1, 2, 3, 4 and 4 h after the carrageenan injection by using plethysmometer (Winter and Porter, 1957). The anti-inflammatory effect of MEDR was calculated by the following equation:…”

Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

“…Cotton pellets weighing 50 mg each were sterilized (autoclaved at 120 • C for one hour) and implanted subcutaneously in rats through a skin incision on their backs, one on each side of the subscapular region (Winter and Porter 1957). Following the implantation, animals were treated orally with the vehicle (10 mL/kg), plant extract (100, 300, and 1000 mg/kg) or dexamethasone (0.5 mg/kg) once a day on six consecutive days.…”

Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

“… Cotton pellet granuloma model 10 Sterile cotton (10±1 mg) soaked in 0.2 ml of distilled water containing penicillin (0.1 mg) was implanted subcutaneously in axilla under ether anaesthesia. HEPBL, diclofenac sodium (5 mg/kg, p.o.)…”