Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

Reddy, Pooja; Gupta, Rajesh; Reddy, Srikanth

doi:10.18203/2319-2003.ijbcp20161556

Cited by 5 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study of Reddy et al [349], the analgesic and anti-inflammatory activity of a hydroalcoholic extract (70% ethanol and 30% distilled water) of P. betle leaves (HEPBL) were demonstrated. Wistar rats and Albino mice were administered different concentrations of HEPBL according to OECD guideline no.…”

Section: Biological Activities Piper Plantsmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

View full text Add to dashboard Cite

Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

show abstract

Section: Biological Activities Piper Plantsmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The analgesic and anti-inflammatory activity of P.betle can be attributed to the presence of phytochemical compounds, namely flavonoids, tannins, phenols and glycosides. [30]…”

Section: Piper Betel Analgesic and Anti-inflammatory Activitymentioning

confidence: 99%

An Exploratory Review of Pharmcological Activities of Notchi Kudineer- A Siddha Herbal Decoction Used in Covid-19

Ragaroobine

Ragavanee

Adaikalam

et al. 2021

Int J Ayu Pharm Res

View full text Add to dashboard Cite

COVID-19 Caused by the novel corona virus (SARS-CoV-2), which has already pushed the entire global community to change their priorities towards finding a suitable anti-viral medicine and a vaccine. While most of the countries have started to prescribe vaccines, which show varied levels of efficacy, finding an effective anti-viral medicine against the virus is still in the early stages despite full-fledged research activities at global level. Many countries particularly those having a rich traditional health science background like India and China started to recommend medicines belonging to local health traditions. The public utilization of those medicines also yielded good results in terms of prevention of the viral infection, reducing the severity of disease or/and reducing the number of days required to recover from the disease as perceived and reported by the patients and doctors. In Tamil Nadu, there are more than 80 million populations. Siddha medicine is the most widely used system of traditional medicine. ‘Suram’ is the Tamil word equivalent to the term ‘fever’. Kabasuram (Also known as Aiya suram) is one among the 64 types of fevers mentioned in Siddha symptoms of which are identical to those of COVID-19. “Notchi kudineer”– a Siddha herbal formulation is being used since many centuries for fever and respiratory disorders with remarkable success. This review article attempts to explore the pharmacological evidence in support of the therapeutic usage of “Notchi kudineer” hence justifying its usage in respiratory related illnesses having fever as a main symptom like the current pandemic of COVID-19.

show abstract

“…Several studies regarding Piper betle extract have proven its anti-cancer, antimicrobial, and antioxidant properties [22] . It is also known for its anti-inflammatory properties proven in animal models [23] . Das et al, in 2016, mentioned 35 active compounds found in Piper betle extract [12] , with α-pinene, sabinene, eugenol, B-selinene, germacerene-B, spathuleneol, globulol, and allyl pyrocatechol diacetate having antimicrobial activities.…”

Section: Figurementioning

confidence: 99%

Antibacterial activity of Piper betle ethanolic extract against ESBL producing Escherichia coli in sepsis induced BALB/c mice

Dzulkarnain¹,

Ratridewi²,

Hantoko³

et al. 2021

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

Sepsis is an organ dysfunction caused by dysregulation of immune response towards systemic infection with high incidence and mortality rate. Innovative breakthrough is required to manage sepsis especially extended spectrum beta lactamase (ESBL) producing Escherichia coli (E. coli) induced sepsis. Utilization of Piper betle extract to manage sepsis could be considered as an alternative therapy and should be proven scientifically so meropenem utilization could be reduced. This study aimed to evaluate the antimicrobial effect of Piper betle ethanolic extract in BALB/c mice infected with ESBL producing E. coli. We identified terpene, apiol, polyphenol, eugenol, myristicin, flavonoid, safrole, lynalil acetate, and allyl tetramethoxy benzene in the Piper betle ethanolic extract using thin layer chromatography. The minimum inhibitory concentration of the Piper betle ethanolic extract against ESBL producing E. coli was 3 mg/mL assessed using broth dilution method. We evaluated the effect of Piper betle ethanolic extract to the survival rate of BALB/c mice infected with ESBL producing E. coli. The single dose administration of Piper betle ethanolic extract prolonged the survival rate of the infected BALB/c mice for 6 hours.

show abstract

Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

Cited by 5 publications

References 10 publications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

An Exploratory Review of Pharmcological Activities of Notchi Kudineer- A Siddha Herbal Decoction Used in Covid-19

Antibacterial activity of Piper betle ethanolic extract against ESBL producing Escherichia coli in sepsis induced BALB/c mice

Contact Info

Product

Resources

About