Effect of Aloe vera as a local drug delivery agent in the management of periodontal diseases: A systematic review and meta-analysis

Jadhav, Ashwini Narendra; Rathod, Surekha; Kolte, Abhay; Bawankar, Pranjali

doi:10.4103/jisp.jisp_40_21

Cited by 3 publications

(3 citation statements)

References 30 publications

(45 reference statements)

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“…Aloe vera gel contains various bioactive components, including polysaccharides, anthraquinones, vitamins, minerals, and enzymes [23,30]. Furthermore, aloe vera components can inhibit the production of inflammatory cytokines and nitric oxide [31,32]. It stimulates fibroblast proliferation and collagen synthesis, possibly aiding tissue repair and regeneration [32].…”

Section: Aloe Vera (Aloe Barbadensis)mentioning

confidence: 99%

“…Furthermore, aloe vera components can inhibit the production of inflammatory cytokines and nitric oxide [31,32]. It stimulates fibroblast proliferation and collagen synthesis, possibly aiding tissue repair and regeneration [32]. Aloe Vera mouthwash has been reported to have comparable effects to chlorhexidine in many studies regarding plaque index without causing tooth discoloration and taste alterations, which are frequently associated with chlorhexidine [30,[33][34][35].…”

Section: Aloe Vera (Aloe Barbadensis)mentioning

confidence: 99%

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Exploring The Potential Of Plant-Based Remedies In Periodontal Treatment: A Mini Review

Molayem,

Pontes

2023

JOMDR

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Periodontal diseases pose a significant challenge to oral and general health with their multifactorial etiology and complex pathogenesis. Traditional treatment approaches primarily rely on mechanical debridement and periodontal surgery. However, emerging research has sparked interest in the potential of phytochemicals in natural remedies in periodontics. This mini-review aims to summarize the current scientific evidence on the use of various plant-based remedies in periodontics. Through an examination of herbal extracts, essential oils, plant-based formulations, and other natural products, this mini-review sheds light on their antimicrobial, antiinflammatory, antioxidant, and immunomodulatory properties. Additionally, the review discusses the potential applications, side effects, limitations, and future perspectives concerning the integration of natural remedies as adjuncts in periodontal care.

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Section: Aloe Vera (Aloe Barbadensis)mentioning

confidence: 99%

Section: Aloe Vera (Aloe Barbadensis)mentioning

confidence: 99%

Exploring The Potential Of Plant-Based Remedies In Periodontal Treatment: A Mini Review

Molayem,

Pontes

2023

JOMDR

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“…Aloe vera (AV) is a perennial succulent commonly used for healing due to its pharmacological and therapeutic properties [22,23]. Balcik and Koral [24] reported that AV had degradable and antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

Variability of Strawberry Fruit Quality and Shelf Life with Different Edible Coatings

Farida,

Hamdani,

Mubarok

et al. 2023

Horticulturae

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Strawberry (Fragraria x ananassa Duch) cv. Tochiotome is nutrient rich. However, it has a short shelf life, especially at room temperature. Coating is one of the methods used to prolong fruit shelf life. Coating materials, such as nano chitosan (NC) and Aloe vera (AV) gel, are edible and safe to consume. The objective was to analyze the interaction between AV gel and NC concentrations and determine the optimal concentration to improve the quality of strawberries at room temperature. This experiment used a factorial randomized block design with treatments of NC (0, 0.5, and 1%) and AV gel (0, 25, and 50%). The results showed an interaction between AV gel and NC concentrations for all variables. The optimum concentrations to improve the fruit quality of strawberries cv. Tochiotome were 25% AV gel with 1% NC, which increased the value by more than twofold compared with the control (no AV gel and NC) until four days after storage. The fruit quality characteristics were fruit hardness (6.57 N), weight loss (1.23%), titratable acidity (0.74 mL), total phenolic (1.79 µg GAE/FW), total flavonoid (29.85 mg QE/g), vitamin C concentration (43.83 mg/100 g), and shelf life (4.66 days). More than 1% NC may enhance quality. In conclusion, AV and NC are a potential treatment for improving the postharvest quality of strawberry.

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Comparative evaluation of 1% melatonin gel in the treatment of intrabony defect: A randomized controlled clinical trial

Gonde

Rathod

Kolte

2022

Journal of Periodontology

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Background The present study aims to evaluate and compare the efficacy of locally delivered 1% melatonin gel as an adjunct to non‐surgical periodontal therapy (NSPT) in treatment of intrabony defect in Stage III periodontitis, clinically, and radiographically using cone‐beam computed tomography (CBCT). Methods This split‐mouth clinical trial randomly allotted 44 bilateral intrabony defect (in 22 patients) into two groups where Group I was treated with NSPT with locally delivered placebo gel while Group II was treated with NSPT with 1% melatonin gel. The intrabony defect fill measured from cemento‐enamel junction (CEJ)‐base of the defect (BD), and the difference in the measurement values of CEJ‒BD from baseline to 6 months denoting the bone fill and bone volume evaluated at 6 months using CBCT were the primary outcome measures. Secondary outcome measures were change in probing depth (PD), clinical attachment level (CAL), plaque index, and modified sulcus bleeding index recorded at baseline, 3 months, and 6 months. Results Both the study groups showed improvements in assessed parameters, however, a significant gain in intrabony defect fill was observed in Group II (1.46 ± 0.58) as compared with Group I (0.50 ± 0.38) and change in bone volume for Group I was 21.4645 ± 8.8980 mm3 and for Group II was 51.8418 ± 30.2329 mm3 with P < 0.0001.The mean reduction in PD and gain in CAL was 3.90 ± 0.78 and 2.94 ± 0.80 in Group II and in Group I it was 3.23 ± 0.90 and 1.96 ± 0.80 (P < 0.0001). Conclusion The use of 1% melatonin gel as an adjunct to NSPT is more beneficial in achieving better clinical and radiographic outcome at 6 months which indicates that adjunct use of melatonin gel to NSPT as a local drug delivery is preferred when compared with NSPT and placebo gel alone.

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Effect of Aloe vera as a local drug delivery agent in the management of periodontal diseases: A systematic review and meta-analysis

Cited by 3 publications

References 30 publications

Exploring The Potential Of Plant-Based Remedies In Periodontal Treatment: A Mini Review

Exploring The Potential Of Plant-Based Remedies In Periodontal Treatment: A Mini Review

Variability of Strawberry Fruit Quality and Shelf Life with Different Edible Coatings

Comparative evaluation of 1% melatonin gel in the treatment of intrabony defect: A randomized controlled clinical trial

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