Effect of allicin on wound healing: an experimental diabetes model

Abstract

Objective: The aim of this study was to investigate the effect of allicin on wound healing in an experimental diabetes model. Method: In this randomised controlled study, 50 Wistar albino rats (25 females, 25 males) each weighing 200–300g were used. To develop the diabetes model, 30 rats were induced with 50mg/kg streptozotocin (STZ); 20 rats were not induced in order to compare diabetic and nondiabetic rats. The diabetic rats were divided into three groups, according to dressing material used (allicin, physiological serum and control, where no dressing was used), and the nondiabetic rats were divided into two groups (allicin and control, where no dressing was used). The wound area was calculated and recorded on days 0, 7, 14 and 21. In addition, biopsies were taken from the wound area on days 0, 7, 14 and 21 and used for microscopic examination. Day 0 was used as a reference to calculate wound healing percentage. Results: On days 7 and 14, there were statistically significant differences between groups. Wound surface areas were smaller in the allicin group than in other groups on days 7 and 14. There were no statistically significant differences between the groups on day 21. In addition, it was determined that neutrophil, mononuclear cell, intraepithelial oedema and dermal oedema density were lower and fibroblast, angiogenesis and collagen density were higher in the allicin groups on days 7 and 14. Conclusion: In this study, allicin was found to be potentially effective on wound healing. Future research should be conducted in order to clarify how it affects wound healing.

Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study

“…10 days after the STZ administration, wound formation studies were performed. In order to begin the experiments, rats were kept for 10 days to obtain a chronic hyperglycemic state [43][44][45].…”

Formulation and Evaluation of Helichrysum italicum Essential Oil-Based Topical Formulations for Wound Healing in Diabetic Rats

“…Diabetes foot ulcers and a high risk of amputation and mortality can impact patients’ quality of life, life roles, and body image, as well as the financial burden placed on patients and their families [ 7 ]. Therefore, proper wound management is crucial for reducing morbidity and improving quality of life.…”

Investigation of the Nursing Theses Related to Wound Care in Turkey: A Systematic Review

“…Diabetic wound, one of the most common complications in diabetic patients, is a serious complication that affects quality of life, can cause limb loss, is difficult to manage and takes long to treat. It has been determined that allicin, tea tree oil, geroniol, and olive leaf extract are used for the treatment of diabetic foot, and these components affect the wound healing process (15,(22)(23)(24). Allicin is garlic, and geroniol are components with antimicrobial activity from rose oil (15,22).…”

“…Allicin is garlic, and geroniol are components with antimicrobial activity from rose oil (15,22). Tea tree oil and olive leaf extract are frequently used in wound care with antiseptic and moisturizing properties (23,24). In the thesis, it is emphasized that these low cost, organic and easily accessible components can be used in the diabetic wound In addition in a thesis, it was stated that regular foot exercise positively affects wound healing in patients with type 2 diabetes (Table 3).…”

“…This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. 6,7,8,27 Standard nursing care 7 Student education with concept map 8 The effect of education on nurses' pressure wound Hydrocolloid wound dressing 13 Effective 13,15,16,17, 22,23, 24.28 Olive leaf extract wound dressing 15 Hypericum perforatum -Klinoptilolit -Hydrocolloid wound dressing 16 Regular foot exercise 17 Wound care with tea tree oil 22 Wound care with geraniol from rose oil 23 Wound care with Allicin 24 Effect of chlorhexidine used in diabetic foot debridement on microorganism reproduction 28…”