2020
DOI: 10.12968/jowc.2020.29.7.388
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Effect of allicin on wound healing: an experimental diabetes model

Abstract: Objective: The aim of this study was to investigate the effect of allicin on wound healing in an experimental diabetes model. Method: In this randomised controlled study, 50 Wistar albino rats (25 females, 25 males) each weighing 200–300g were used. To develop the diabetes model, 30 rats were induced with 50mg/kg streptozotocin (STZ); 20 rats were not induced in order to compare diabetic and nondiabetic rats. The diabetic rats were divided into three groups, according to dressing material used (allicin, physio… Show more

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Cited by 14 publications
(11 citation statements)
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“…10 days after the STZ administration, wound formation studies were performed. In order to begin the experiments, rats were kept for 10 days to obtain a chronic hyperglycemic state [43][44][45].…”
Section: Experimental Design Of Wound Healing Experimentsmentioning
confidence: 99%
“…10 days after the STZ administration, wound formation studies were performed. In order to begin the experiments, rats were kept for 10 days to obtain a chronic hyperglycemic state [43][44][45].…”
Section: Experimental Design Of Wound Healing Experimentsmentioning
confidence: 99%
“…Diabetes foot ulcers and a high risk of amputation and mortality can impact patients’ quality of life, life roles, and body image, as well as the financial burden placed on patients and their families [ 7 ]. Therefore, proper wound management is crucial for reducing morbidity and improving quality of life.…”
Section: Introductionmentioning
confidence: 99%
“…Diabetic wound, one of the most common complications in diabetic patients, is a serious complication that affects quality of life, can cause limb loss, is difficult to manage and takes long to treat. It has been determined that allicin, tea tree oil, geroniol, and olive leaf extract are used for the treatment of diabetic foot, and these components affect the wound healing process (15,(22)(23)(24). Allicin is garlic, and geroniol are components with antimicrobial activity from rose oil (15,22).…”
Section: Discussionmentioning
confidence: 99%
“…Allicin is garlic, and geroniol are components with antimicrobial activity from rose oil (15,22). Tea tree oil and olive leaf extract are frequently used in wound care with antiseptic and moisturizing properties (23,24). In the thesis, it is emphasized that these low cost, organic and easily accessible components can be used in the diabetic wound In addition in a thesis, it was stated that regular foot exercise positively affects wound healing in patients with type 2 diabetes (Table 3).…”
Section: Discussionmentioning
confidence: 99%
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