Heat-polymerized polymethyl methacrylate (PMMA) has been the material of choice for removable prostheses because of its good mechanical and physical properties. [1][2][3][4][5] However, monomer leaching is a drawback, which is responsible for water sorption and affects dimensional stability and surface properties. [1][2][3][4][5][6][7][8] Advances in digital dentistry and computer-aided design and computer-aided manufacturing (CAD-CAM) technologies have led to the introduction of prepolymerized PMMA blocks. [8][9][10][11][12][13][14][15] Previous studies have reported improved surface properties, less porosity, and microbial adherence to CAD-CAM PMMAs, which may be attributed to the polymerization of blocks under high pressure and temperature. 9,10,12,[16][17][18][19][20] The porous surface of PMMA allows the accumulation of denture biofilm, predominantly composed of the Candida species and bacterial pathogens responsible for chronic atrophic candidiasis and halitosis.