Effect of Alendronate on Osteoclast Differentiation and Bone Volume in Transplanted Bone

Kawata, Toshitsugu; Tenjou, Kaoru; Tokimasa, Chiyoko; Fujita, Tadashi; Kaku, Masato; Matsuki, Akira; Kohno, Satoru; Tsutsui, K.; Ohtani, Junji; Motokawa, Masaharu; Shigekawa, Mao; Tohma, Yuiko; Tanne, Kazuo

doi:10.1538/expanim.53.47

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…Bisphosphonates inhibit the degradation of bone by increasing the rate of osteoclast apoptosis or inhibiting osteoclast differentiation ( 64 ) and are the most used drug for the treatment of osteoporosis in the UK. We simulated the effect of administering bisphosphonates at increasing doses by increasing the rate of osteoclast apoptosis ( k deathOcl ) from 6.5e−5 to 1.3e−4 (Figure 11 E).…”

Section: Resultsmentioning

confidence: 99%

Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing

Proctor

Gartland

2016

Front. Endocrinol.

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Bone remodeling is the continuous process of bone resorption by osteoclasts and bone formation by osteoblasts, in order to maintain homeostasis. The activity of osteoclasts and osteoblasts is regulated by a network of signaling pathways, including Wnt, parathyroid hormone (PTH), RANK ligand/osteoprotegrin, and TGF-β, in response to stimuli, such as mechanical loading. During aging there is a gradual loss of bone mass due to dysregulation of signaling pathways. This may be due to a decline in physical activity with age and/or changes in hormones and other signaling molecules. In particular, hormones, such as PTH, have a circadian rhythm, which may be disrupted in aging. Due to the complexity of the molecular and cellular networks involved in bone remodeling, several mathematical models have been proposed to aid understanding of the processes involved. However, to date, there are no models, which explicitly consider the effects of mechanical loading, the circadian rhythm of PTH, and the dynamics of signaling molecules on bone remodeling. Therefore, we have constructed a network model of the system using a modular approach, which will allow further modifications as required in future research. The model was used to simulate the effects of mechanical loading and also the effects of different interventions, such as continuous or intermittent administration of PTH. Our model predicts that the absence of regular mechanical loading and/or an impaired PTH circadian rhythm leads to a gradual decrease in bone mass over time, which can be restored by simulated interventions and that the effectiveness of some interventions may depend on their timing.

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Section: Resultsmentioning

confidence: 99%

Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing

Proctor

Gartland

2016

Front. Endocrinol.

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“…Os estudos sobre o uso tópico de drogas surgiram com o objetivo de estabelecer uma dose ótima de uma substância bioativa precisamente no local onde é desejada, em vez de se distribuir excessivamente e de forma desnecessária por todo o corpo, através da circulação sistêmica (MÖLLER et al, 2014). Acredita-se que a aplicação local do ALN evita a maioria dos efeitos colaterais relacionados à administração sistêmica, proporcionando uma maior concentração local (KAWATA et al, 2004;SHARMA;PRADEEP, 2012a, b).…”

Section: Discussionunclassified

Complicações No Rejuvenescimento Orofacial

Queiroz¹,

Cardoso²,

Alencar³

2019

Odontologia: Serviços Disponíveis E Acesso 2

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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“…The optimal dose of AL, as well as its effect on ectopic bone graft resorption as determined by conventional radiographic analysis, was tested by Kawata et al [24]. The grafted bone disappeared in the control group (grated bone immersed in saline solution) after 5 weeks post-surgery.…”

Section: Discussionmentioning

confidence: 99%

The influence of early bisphosphonate treatment on craniofacial radiographic bone density

Araújo

Mobile²,

Azevedo³

et al. 2019

BDS

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Objective: To evaluate the effects of alendronate (AL), a bisphosphonate, on visual bone density by means of a radiographic analysis. Material and methods: Sixty-two Wistar rats were divided into four groups: Group AA (AL with autogenous graft); group AW (AL without autogenous graft) both receiving AL on alternate days for 4 weeks before surgery; control group CA (with autogenous graft); group CW (without autogenous graft) both receiving saline solution before surgery. Experimental periods of evaluation were 2 weeks and 4 weeks post-surgery. Conventional and digital radiographs were obtained, and a 5-point grading system (score) was used to assess visual radiographic bone density. Results: There were no statistical differences between CA and AA groups at 2 and 4 weeks. The AA group had a higher mean score of bone density than the CW and AW groups at 2 weeks (P < 0.05). The CA and AA groups had higher scores of bone density than the CW and AW groups at 4 weeks (P < 0.05). Conclusions: Treatment with AL did not affect radiographic bone density at 2 and 4 weeks after surgery. The presence of an autograft resulted in higher scores of bone density.

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Effect of Alendronate on Osteoclast Differentiation and Bone Volume in Transplanted Bone

Cited by 7 publications

References 14 publications

Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing

Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing

Complicações No Rejuvenescimento Orofacial

The influence of early bisphosphonate treatment on craniofacial radiographic bone density

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