Effect of Akkermansia muciniphila, Faecalibacterium prausnitzii, and Their Extracellular Vesicles on the Serotonin System in Intestinal Epithelial Cells

Yaghoubfar, Rezvan; Behrouzi, Ava; Banadkoki, Ehsan Zare; Ashrafian, Fatemeh; Lari, Arezou; Vaziri, Farzam; Nojoumi, Seyed Ali; Fateh, Abolfazl; Khatami, Shohreh; Siadat, Seyed Davar

doi:10.1007/s12602-021-09786-4

Cited by 28 publications

(29 citation statements)

References 48 publications

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“…A previous study confirmed the biological effect of A. muciniphila -derived EVs on the enhancement of serotonin production in the colon and hippocampus of mouse models and Caco-2 cell lines [ 64 ]. A similar study established that treatment of Faecalibacterium prausnitzii and A. muciniphila -derived EVs affected the expression of genes involved in serotonin release in the Caco-2 cell line [ 71 ]. Moreover, EVs from Bacillus subtilis were shown to be transported across Caco-2 cells to be secreted at the opposite cell surface side [ 72 ].…”

Section: The Importance Of Bacterial Evs In Various Axesmentioning

confidence: 95%

Commensal and Pathogenic Bacterial-Derived Extracellular Vesicles in Host-Bacterial and Interbacterial Dialogues: Two Sides of the Same Coin

Tarashi

Zamani

Omrani

et al. 2022

Journal of Immunology Research

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Extracellular vesicles (EVs) cause effective changes in various domains of life. These bioactive structures are essential to the bidirectional organ communication. Recently, increasing research attention has been paid to EVs derived from commensal and pathogenic bacteria in their potential role to affect human disease risk for cancers and a variety of metabolic, gastrointestinal, psychiatric, and mental disorders. The present review presents an overview of both the protective and harmful roles of commensal and pathogenic bacteria-derived EVs in host-bacterial and interbacterial interactions. Bacterial EVs could impact upon human health by regulating microbiota–host crosstalk intestinal homeostasis, even in distal organs. The importance of vesicles derived from bacteria has been also evaluated regarding epigenetic modifications and applications. Generally, the evaluation of bacterial EVs is important towards finding efficient strategies for the prevention and treatment of various human diseases and maintaining metabolic homeostasis.

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Section: The Importance Of Bacterial Evs In Various Axesmentioning

confidence: 95%

Commensal and Pathogenic Bacterial-Derived Extracellular Vesicles in Host-Bacterial and Interbacterial Dialogues: Two Sides of the Same Coin

Tarashi

Zamani

Omrani

et al. 2022

Journal of Immunology Research

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“…Also, the under-representation of Faecalibacterium and over-representation of Actinobacteria and Enterobacteriaceae, are related to clinical characteristics and metabolic markers in MDD and bipolar disorder [219]. Specific strains like Akkermansia muciniphila and Faecalibacterium prausnitzii, have been studied in vitro with human epithelial colorectal cells, showing an impact on the expression of serotonin system-related genes [220] like the up-regulation of SERT gene (serotonin transporters) [221]. So, these two are promising probiotics also as potential modulators of the homeostasis at the serotonin system level.…”

Section: Emulation Of Microbial Metabolism 421 Adjuvant Therapy Suppl...mentioning

confidence: 99%

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

et al. 2022

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The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning of the organism, affecting the health and disease status of the individuals. There is continuous and bidirectional communication between gut microbiota and the host, conforming to a unique entity known as “holobiont”. Among these crosstalk mechanisms, the gut microbiota synthesizes a broad spectrum of bioactive compounds or metabolites which exert pleiotropic effects on the human organism. Many of these microbial metabolites can cross the blood–brain barrier (BBB) or have significant effects on the brain, playing a key role in the so-called microbiota-gut-brain axis. An altered Microbiota-Gut-Brain (MGB) axis is a major characteristic of many neuropsychiatric disorders, including major depressive disorder (MDD). Significative differences between gut eubiosis and dysbiosis in mental disorders like MDD with their different metabolite composition and concentrations are being discussed. In the present review, the main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology. Conclusions from promising translational approaches related to microbial metabolome will be addressed in more depth to discuss their possible clinical value in the management of MDD patients.

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“…Yaghoubfar et al conducted a recent study to examine the role of gut microbiota members like Akkermansia muciniphila and Fecalibacterium prausnitzii on the serotonin system ( Yaghoubfar et al., 2021 ). They examined the effect of these bacteria and their extracellular vesicles (EVs) on the gene expression of the serotonin system using Caco-2 cells ( Yaghoubfar et al., 2021 ). The differentiated Caco-2 cells were treated with A. muciniphila and F. prausnitzii.…”

Section: Microbiome Signature and The Pathogenesis Of Covid-19mentioning

confidence: 99%

“…The differentiated Caco-2 cells were treated with A. muciniphila and F. prausnitzii. After 24 h, the serotonin level was measured using ELISA, and the gene expression of serotonin system-related genes was studied using qPCR ( Yaghoubfar et al., 2021 ). They found that treatment of cells with EVs increased the serotonin level, while bacteria failed to induce this effect ( Yaghoubfar et al., 2021 ).…”

Section: Microbiome Signature and The Pathogenesis Of Covid-19mentioning

confidence: 99%

Role of the Microbiome in the Pathogenesis of COVID-19

2022

Front. Cell. Infect. Microbiol.

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The ongoing pandemic coronavirus disease COVID-19 is caused by the highly contagious single-stranded RNA virus, SARS-coronavirus 2 (SARS-CoV-2), which has a high rate of evolution like other RNA viruses. The first genome sequences of SARS-CoV-2 were available in early 2020. Subsequent whole-genome sequencing revealed that the virus had accumulated several mutations in genes associated with viral replication and pathogenesis. These variants showed enhanced transmissibility and infectivity. Soon after the first outbreak due to the wild-type strain in December 2019, a genetic variant D614G emerged in late January to early February 2020 and became the dominant genotype worldwide. Thereafter, several variants emerged, which were found to harbor mutations in essential viral genes encoding proteins that could act as drug and vaccine targets. Numerous vaccines have been successfully developed to assuage the burden of COVID-19. These have different rates of efficacy, including, although rarely, a number of vaccinated individuals exhibiting side effects like thrombosis. However, the recent emergence of the Britain strain with 70% more transmissibility and South African variants with higher resistance to vaccines at a time when several countries have approved these for mass immunization has raised tremendous concern regarding the long-lasting impact of currently available prophylaxis. Apart from studies addressing the pathophysiology, pathogenesis, and therapeutic targets of SARS-CoV-2, analysis of the gut, oral, nasopharyngeal, and lung microbiome dysbiosis has also been undertaken to find a link between the microbiome and the pathogenesis of COVID-19. Therefore, in the current scenario of skepticism regarding vaccine efficacy and challenges over the direct effects of currently available drugs looming large, investigation of alternative therapeutic avenues based on the microbiome can be a rewarding finding. This review presents the currently available understanding of microbiome dysbiosis and its association with cause and consequence of COVID-19. Taking cues from other inflammatory diseases, we propose a hypothesis of how the microbiome may be influencing homeostasis, pro-inflammatory condition, and the onset of inflammation. This accentuates the importance of a healthy microbiome as a protective element to prevent the onset of COVID-19. Finally, the review attempts to identify areas where the application of microbiome research can help in reducing the burden of the disease.

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Effect of Akkermansia muciniphila, Faecalibacterium prausnitzii, and Their Extracellular Vesicles on the Serotonin System in Intestinal Epithelial Cells

Cited by 28 publications

References 48 publications

Commensal and Pathogenic Bacterial-Derived Extracellular Vesicles in Host-Bacterial and Interbacterial Dialogues: Two Sides of the Same Coin

Commensal and Pathogenic Bacterial-Derived Extracellular Vesicles in Host-Bacterial and Interbacterial Dialogues: Two Sides of the Same Coin

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

Role of the Microbiome in the Pathogenesis of COVID-19

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