Effect of airborne lead on blood lead

Kinetics of lead in blood after the end of occupational exposure.

“…There was no such clear corresponding tendency amo ng the retired workers. relation between the air lead level and PbB (eg, in references 12,13,19), between PbB and plasma lead (20,42,45), and between PbB and the lead level in urine (12,13,56,67) could favor the choice of a nonlinear model. However, elimination rates similar to ours have been reported earlier, both for subjects far less (I I , 13,53) and far more (14,46) exposed.…”

“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16] years, that of Y (3) was 0.3 (range 0.0-2.6) p.mol/I, and that of T V2 (3) was > 100 (range 4.9-00) years.…”

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

“…clearance of blood lead increases with increasing blood lead concentrations above 25 μg/dL (Chamberlain 1983). The mechanism for this has not been elucidated and could involve a shift in the distribution of lead in blood towards a fraction having a higher glomerular filtration rate (e.g., lower molecular weight complex), a capacity-limited mechanism in the tubular reabsorption of lead, or the effects of lead-induced nephrotoxicity on lead reabsorption.…”

Historical perspective on lead biokinetic models.

“…Although these were very useful studies, because of the short half-life of 212Pb, processes longer than a few days cannot be examined; such processes include blood pool turnover, biliary excretion and other sources of endogenous fecal excretion, or hair or nail uptake. Chamberlain (29) (30). My teachers George Wetherill and Joel Kopple enabled me to address the question of how much lead was entering people by respiration compared to ingestion.…”