2002
DOI: 10.1016/s0167-0115(02)00096-4
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Effect of age on α-calcitonin gene-related peptide-mediated delayed cardioprotection induced by intestinal preconditioning in rats

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Cited by 16 publications
(12 citation statements)
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“…Protective effects of CGRP have also been demonstrated in experimental settings of ischemia and reperfusion [10][11][12][13] . Furthermore, CGRP mediates organ-protective effects of ischemic preconditioning in the experimental settings [15,30,31] .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Protective effects of CGRP have also been demonstrated in experimental settings of ischemia and reperfusion [10][11][12][13] . Furthermore, CGRP mediates organ-protective effects of ischemic preconditioning in the experimental settings [15,30,31] .…”
Section: Discussionmentioning
confidence: 99%
“…CGRP also mediates ischemic preconditioning and can protect against ischemia reperfusion injury in hearts of rats, pigs and dogs as well as in rats' stomach [10][11][12][13] . In addition, increased levels of CGRP have been shown in chronic pancreatitis [14] .…”
mentioning
confidence: 99%
“…It is now apparent that protection from IPC spreads from distant organs to the heart (Pell et al, 1998;Wolfrum et al, 2002) possibly via activation of the autonomic nervous system (Gho et al, 1996;Schoemaker & Van Heijningen, 2000;Liem et al, 2002;Wolfrum et al, 2002). It is possible that the release of local triggers of IPC activates the autonomic nervous system either directly (Schoemaker & Van Heijningen, 2000;Liem et al, 2002) or via sensory nerves (Tang et al, 1999;Xiao et al, 2001;Hu et al, 2002), and transfers the signal to the myocardium or other remote tissues. Evidence exists that sympathovagal regulation might be related to the protective mechanism of IPC (Loukogeorgakis et al, 2005;Wu et al, 2005).…”
Section: Heart Rate -A Measure Of Autonomic Nervous System Activitymentioning
confidence: 99%
“…Aging is associated with decrease in the protective effect of conditioning in animals [70][71][72][73][74][75] as well as in humans [76][77][78]. The effects of remote ischemic preconditioning [79] and pharmacological preconditioning [80] are also reduced. Similarly, postconditioning is less effective with aging [71,81].…”
Section: Effect Of Age and Cardiovascular Risk Factors On Conditioningmentioning
confidence: 99%