Effect of age on α-calcitonin gene-related peptide-mediated delayed cardioprotection induced by intestinal preconditioning in rats

Protective Effects and Anti-Inflammatory Pathways of Exogenous Calcitonin Gene-Related Peptide in Severe Necrotizing Pancreatitis

“…Protective effects of CGRP have also been demonstrated in experimental settings of ischemia and reperfusion [10][11][12][13] . Furthermore, CGRP mediates organ-protective effects of ischemic preconditioning in the experimental settings [15,30,31] .…”

“…CGRP also mediates ischemic preconditioning and can protect against ischemia reperfusion injury in hearts of rats, pigs and dogs as well as in rats' stomach [10][11][12][13] . In addition, increased levels of CGRP have been shown in chronic pancreatitis [14] .…”

Chronobiological Aspects of the Heart Rhythm Disorders at the Change of Pulmonary Ventilation in Rat Model

“…It is now apparent that protection from IPC spreads from distant organs to the heart (Pell et al, 1998;Wolfrum et al, 2002) possibly via activation of the autonomic nervous system (Gho et al, 1996;Schoemaker & Van Heijningen, 2000;Liem et al, 2002;Wolfrum et al, 2002). It is possible that the release of local triggers of IPC activates the autonomic nervous system either directly (Schoemaker & Van Heijningen, 2000;Liem et al, 2002) or via sensory nerves (Tang et al, 1999;Xiao et al, 2001;Hu et al, 2002), and transfers the signal to the myocardium or other remote tissues. Evidence exists that sympathovagal regulation might be related to the protective mechanism of IPC (Loukogeorgakis et al, 2005;Wu et al, 2005).…”

Conditioning of the heart: From pharmacological interventions to local and remote protection

“…Aging is associated with decrease in the protective effect of conditioning in animals [70][71][72][73][74][75] as well as in humans [76][77][78]. The effects of remote ischemic preconditioning [79] and pharmacological preconditioning [80] are also reduced. Similarly, postconditioning is less effective with aging [71,81].…”