Effect of age on the response of blood lipids, body composition, and aerobic power to physical conditioning and deconditioning

Giada, Franco; Vigna, Giovanni Battista; Vitale, E.; Baldo-Enzi, Goretta; Bertaglia, M.; Crecca, Rosa; Fellin, Renato

doi:10.1016/0026-0495(95)90259-7

Cited by 33 publications

(34 citation statements)

References 32 publications

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“…Some studies have reported a protective effect of exercise on the lipid profile, mainly in terms of increased HDL-C (e.g., 6), whereas others have found little (7) or no effect (27). Neither age nor menopausal status has been identified as an effect modifier (11). Our study focused on differences in the usual, everyday physical activities of the study populations, but it may be that only high-intensity activities affect lipid levels (21).…”

Section: Discussionmentioning

confidence: 94%

No Physical Activity ?? CETP 1b.-629 Interaction Effects on Lipid Profile

Bernstein¹,

Costanza²,

James³

et al. 2003

Medicine & Science in Sports & Exercise

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Section: Discussionmentioning

confidence: 94%

No Physical Activity ?? CETP 1b.-629 Interaction Effects on Lipid Profile

Bernstein¹,

Costanza²,

James³

et al. 2003

Medicine & Science in Sports & Exercise

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“…However, the results presented here demonstrate that deconditioning reversed the training effect on ASIPA back to the pretraining state. This phenomenon can be explained by the reversed alteration of catecholamine, antioxidants, 34 and lipoprotein patterns 40 after deconditioning.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise Training and Deconditioning on Platelet Aggregation Induced by Alternating Shear Stress in Men

Chen

2005

ATVB

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Objective-Alternating shear stress, which resembles the flow condition in stenotic arteries, induces platelet aggregation.This study investigated how exercise training and deconditioning influence alternating shear-induced platelet aggregation (ASIPA) and clarify the mechanisms underlying ASIPA. Methods and Results-Thirty healthy male sedentary subjects were randomly divided into control and trained groups. The trained men were trained on a bicycle ergometer at Ϸ60% of maximal oxygen consumption for 30 minutes per day, 5 days per week for 8 weeks, and then were deconditioned for 8 weeks. The experimental results indicate the following:(1) short-term strenuous exercise increases the extent of ASIPA and is accompanied by increased the von Willebrand factor (vWF) binding and P-selectin expression on platelets in both the control and trained groups, whereas the enhancement of platelet function decreases after exercise training in trained subjects; (2) at rest and immediately after exercise, ASIPA and the vWF binding and P-selectin expression on platelets are reduced by training, but remain unchanged in the control group; and (3) Key Words: training Ⅲ detraining Ⅲ shear stress Ⅲ platelets Ⅲ adhesion molecules L ifestyle habits such as exercise may have significant influence on the risk of major vascular thrombotic events. 1,2 Previous studies have suggested that the risk of primary cardiac arrest transiently increases during vigorous exercise, 3,4 whereas regular exercise is associated with an overall decreased risk of cardiovascular diseases. 5,6 Shear-induced platelet aggregation (SIPA) is important in arterial thrombosis, which is a major contributing factor for atherothrombotic occlusion of blood vessels. 7 Therefore, it is important to distinguish the shearmediated thrombotic events that occur between short-term bouts of exercise and physical conditioning. According to our earlier study of male patients with stable angina, strenuous acute exercise can increase the capacity of adhered platelets to withstand physiological flow shear stress. 8 A previous investigation also demonstrated that SIPA increased after strenuous treadmill exercise in patients with effort angina. 9 However, the effects of exercise training and detraining on shearmediated platelet activation and its underlying mechanisms have not yet been studied. See page 265Pathological, high shear stress induces binding of von Willebrand factor (vWF) to the platelet glycoprotein (GP) Ib complex on platelets. This interaction transduces signals in platelets, subsequently activating GP IIb/IIIa complex. The activated GP IIb/IIIa complex then binds to fibrinogen, stabilizing the aggregated platelets. 10,11 Our recent investigation showed that short-term intense exercise promoted SIPA, possibly by improving the ability of vWF to bind to platelets and the subsequent activation of GPIIb/IIIa complexes to sustained high shear stress. 12 In fact, blood flow in stenotic vessel follows a complex pattern of hydrodynamics in that flow rate first increases dramatical...

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“…Neither age 45 nor menopausal status 46 was previously identified as a potential effect modifier. Among the 862 women in our sample, 418 (51%) were premenopausal, 62 (7%) were perimenopausal, and 346 (42%) were postmenopausal (of whom 48% were currently on hormone replacement therapy).…”

Section: Bernstein Et Almentioning

confidence: 98%

Physical Activity May Modulate Effects of ApoE Genotype on Lipid Profile

Bernstein

Costanza

James

et al. 2002

ATVB

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Abstract-Increased levels of physical activity may improve the lipid profile, but is this effect identical across apolipoprotein E (apoE) genotypes? A population-based cross-sectional survey conducted from 1999 to 2000 included 1708 randomly selected men and women aged 35 to 74 years. A validated physical activity questionnaire measured, for each participant, the total energy expenditure and its percentage used in high-intensity activities (%high-intensity activity), eg, brisk walking and sports. The effects of the apoEϫ%high-intensity activity interaction on the lipid profile were investigated by using multiple linear regression models. Among men, increased %high-intensity activity had greater protective effects in the apoE4 group regarding (1) high density lipoprotein (HDL) cholesterol (PϽ0.001), compared with either the apoE2 (interaction Pϭ0.05) or apoE3 (interaction PϽ0.03) groups, and (2)

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Effect of age on the response of blood lipids, body composition, and aerobic power to physical conditioning and deconditioning

Cited by 33 publications

References 32 publications

No Physical Activity ?? CETP 1b.-629 Interaction Effects on Lipid Profile

No Physical Activity ?? CETP 1b.-629 Interaction Effects on Lipid Profile

Effects of Exercise Training and Deconditioning on Platelet Aggregation Induced by Alternating Shear Stress in Men

Physical Activity May Modulate Effects of ApoE Genotype on Lipid Profile

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