Effect of age on immunocytochemical staining characteristics of adenohypophyseal cells in Mongolian pony mares and stallions

Tan, Jing-He; Sasaki, Fumihiko

doi:10.2460/ajvr.2000.61.826

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…5, 16,[21][22][23] The hypothesis that PPIA in horses may result from a loss of the dopaminergic innervation of the pars intermedia is consistent with the finding that the dopamine concentration of PPIA tissue was < 12% of that in normal pars intermedia tissue. 24 Pituitary gland weight was significantly greater in pregnant and lactating mares than nonpregnant mares.…”

Section: Discussionsupporting

confidence: 63%

“…In old mares (15 to 22 years old), the percentage of follicle-stimulating hormone cells increased, whereas the cell area of cells that produce follicle-stimulating hormone and luteinizing hormone decreased. 16 An age-related increase in the presence of pituitary lesions in the pars distalis and pars intermedia was detected in geldings, mares overall, and nonpregnant mares, but not in pregnant and lactating mares. The fact that the pituitary pars intermedia, but not the pars distalis, contained significantly more lesions in pregnant and lactating mares than geldings and stallions leads to the hypothesis that the pars intermedia in horses may be more sensitive to obvious proliferative effects of steroids produced by the ovary than the pars distalis.…”

Section: Discussionmentioning

confidence: 92%

“…Before fixation, pituitary glands were weighed and measured in both the transverse (length and width) and the sagittal planes (height) followed by dissection as described previously. 16 Sections of 5 to 7 µm were mounted and stained with H&E stain. Masson trichrome and periodic acid-Schiff stains were used when appropriate.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of pituitary gland anatomy and histopathologic findings in clinically normal horses and horses and ponies with pituitary pars intermedia adenoma

Kolk¹,

Heinrichs²,

Amerongen³

et al. 2004

ajvr

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Objective—To determine size and weight of the pituitary gland and associations between pituitary gland size and weight and sex and age in horses without clinical signs associated with pituitary pars intermedia adenoma (PPIA) and horses and ponies with PPIA. Animals—Pituitary glands from 100 horses without clinical signs of PPIA and 19 horses and 17 ponies with PPIA. Procedures—Pituitary glands were weighed, measured, and examined histologically by use of H&E stain. Masson trichrome and periodic acid-Schiff staining were used, when appropriate. Histologic lesions in the pars intermedia, pars distalis, or both were classified as no significant lesions, single or multiple cysts, focal or multifocal hyperplasia, single or multiple microadenomas, and adenoma. Relative pituitary weight (RPW) was calculated as pituitary weight (grams) divided by body weight (grams). Results—There was an age-related increase in the presence of pituitary lesions in the pars distalis and pars intermedia in geldings, mares overall, and nonpregnant mares. Mean (± SD) RPW in horses with PPIA was not significantly different from ponies with PPIA (15 ± 5.9 X 10–6 and 16 ± 7.2 × 10–6, respectively). Maximum pituitary weight in a horse with PPIA was 13.9 g (RPW, 2.9 × 10–5). Plasma glucose concentration was positively correlated with RPW in ponies with PPIA. Conclusions and Clinical Relevance—Pituitary lesions may be a factor in horses with insulin resistance and laminitis before development of clinical signs of PPIA. Ovarian steroids may be involved in the pathogenesis of lesions in the pars intermedia. (Am J Vet Res 2004;65:1701–1707)

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 92%

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Evaluation of pituitary gland anatomy and histopathologic findings in clinically normal horses and horses and ponies with pituitary pars intermedia adenoma

Kolk¹,

Heinrichs²,

Amerongen³

et al. 2004

ajvr

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“…18 The function of equine testes during postnatal life may be associated with development of growth hormone-secreting cells while suppressing development of cells producing follicle-stimulating hormone, luteinizing hormone, and prolactin. 19 These changes in pituitary cells of Mongolian horses are age dependent. 18 The possible effect of sampling stress on steroid concentrations, especially cortisol concentration, also must be considered as a potential source of variability in hormone concentrations.…”

Section: Discussionmentioning

confidence: 98%

“…Somatotrophs, growth hormone-secreting cells, are more abundant in stallions, whereas gonadotrophs, follicle-stimulating hormone and luteinizing hormone-secreting cells, and lactotrophs, prolactin-secreting cells, are more abundant in mares 18 . The function of equine testes during postnatal life may be associated with development of growth hormone-secreting cells while suppressing development of cells producing follicle-stimulating hormone, luteinizing hormone, and prolactin 19 . These changes in pituitary cells of Mongolian horses are age dependent 18…”

Section: Discussionmentioning

confidence: 99%

Blood Steroid Concentrations in Domestic Mongolian Horses

et al. 2010

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Traditionally, analysis of blood cortisol alone has been used to evaluate adrenal function. Currently, multisteroid analyses are considered more informative than analysis of a single hormone to assess adrenal function. The objective of the present research was to create a database for steroid reference values for domestic Mongolian horses. Seven adrenal steroid levels were determined in the blood of 18 colts, 34 stallions, 25 geldings, 17 fillies, and 29 mares. Results were as follows (lowest and highest group median, in nanograms per milliliter): progesterone: <0.030 (fillies), 4.30 (mares), and 0.070 (all horses); 17-OH-progesterone: 0.070 (colts), 0.520 (mares), and 0.110 (all horses); androstenedione: 0.101 (colts), 0.256 (stallions), and 0.181 (all horses); testosterone: <0.040 (mares, stallions, and fillies), 0.040 (geldings and colts), and <0.40 (all horses); estradiol: 0.066 (stallions), 0.093 (fillies), and 0.085 (all horses); cortisol: 23.040 (colts), 70.210 (geldings), and 50.770 (all horses); and aldosterone: 0.018 (colts), 0.297 (geldings), and 0.191 (all horses). Overall medians indicate that cortisol (98.70%) is the predominant steroid, followed by aldosterone (0.37%), androstenedione (0.35%), 17-OH-progesterone (0.21%), estradiol (0.17%), progesterone (0.14%), and testosterone (0.06%). This information provides adrenal and gonadal steroid reference concentrations to assist in physiological characterization and diagnosis of endocrine disorders in domestic Mongolian horses.

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Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

et al. 2021

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Effect of age on immunocytochemical staining characteristics of adenohypophyseal cells in Mongolian pony mares and stallions

Abstract: Differences among percentages and cell areas of pituitary cell types in old horses may be associated with degeneration of the sex organs.

Cited by 4 publications

References 17 publications

Evaluation of pituitary gland anatomy and histopathologic findings in clinically normal horses and horses and ponies with pituitary pars intermedia adenoma

Evaluation of pituitary gland anatomy and histopathologic findings in clinically normal horses and horses and ponies with pituitary pars intermedia adenoma

Blood Steroid Concentrations in Domestic Mongolian Horses

Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

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