Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD

Zhou, Tongxi; Niu, Mengfan; Liu, Ruichen; Li, Li

doi:10.3389/fgene.2022.901827

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The remaining 12 rats in the normal diet group were changed to control group (C), and the high-fat diet group was divided into model group (M) and exercise group (E). E group conducted 8-week exercise intervention with reference to Zhou et al [ 8 ]: 7 d/w, 60 min/t, and 15 m/min ( Figure 1 ). The rats were euthanized at twenty-four hours after the intervention experiment.…”

Section: Methodsmentioning

confidence: 99%

Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD

Liu

Niu

et al. 2022

BioMed Research International

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Objective. To observe the improvement effect of aerobic exercise on liver tissue of rats with NAFLD, explore whether it can reduce NAFLD symptoms without drug dependence, and provide certain data support for the relief of NAFLD by aerobic exercise. Methods. 40 healthful male SD rats have been divided into ordinary diet and high-fat diet. To observe whether the molding is forming after 6 weeks, then divide the rats into control (C), model (M), and exercise (E) group. E group received 8-week aerobic exercise intervention. Serum and liver samples were taken and analyzed after the last intervention. Results. The morphological of hepatocytes between C and M group becomes different, and the accumulation of fat and inflammatory cells was significant, suggesting that NAFLD symptoms appeared, that is, the model was successfully established. Compared with M group, the morphology of rats in E group was improved in varying degrees. The quantity of ALT, AST, and MDA of rats in M group is increased, and the SOD activity is significantly reduced ( P < 0.01 ). However, aerobic exercise intervention changed those result ( P < 0.01 ). Conclusions. Aerobic exercise can relieve oxidative stress damage, lipid peroxidation levels, and chronic inflammatory status in rats with NAFLD, which can reduce NAFLD symptoms without drug dependence, and is expected to become a means of NAFLD treatment.

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Section: Methodsmentioning

confidence: 99%

Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD

Liu

Niu

et al. 2022

BioMed Research International

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“…(2) Studies on the treatment of NAFLD. Many pieces of evidence showed that calorie restriction ( 18 , 19 ), fat restriction ( 20 , 21 ), carbohydrate reduction ( 22 , 23 ), and appropriate vitamin supplementation ( 24 , 25 ) in diet therapy, aerobic exercise ( 26 , 27 ) resistance exercise ( 28 , 29 ) and high-intensity interval training ( 30 ) in exercise therapy had good therapeutic effects. Moreover, clinical experiments have proved that combining diet and exercise may achieve better therapeutic efficacy than a single one ( 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Shi,

Xiong,

Song

et al. 2024

Front. Nutr.

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IntroductionThe primary treatment for non-alcoholic fatty liver disease (NAFLD) is modifying lifestyle through dietary or exercise interventions. In recent decades, it has received increasing attention. However, the lack of bibliometric analysis has posed a challenge for researchers seeking to understand the overall trends in this field.MethodsAs of February 3rd, 2024, 876 articles on treating NAFLD through diet or exercise therapy from 2013 to 2023 had been retrieved. Two software tools, VOSviewer and CiteSpace, were utilized to analyze the growth of publications, countries, institutions, authors, journals, citations, and keywords. Additionally, the keywords with strong citation burstiness were identified to determine the changes and future trends of research hotspots in this field.ResultsChina had the highest number of articles, followed by the United States and South Korea. Yonsei University and Nutrients were the institutions and journals with the most significant contributions. Professor Younossi Zobair M, from the United States, is the most prolific author in this field. Through analyzing the keywords, three research hotspots were identified: research on the pathogenesis of NAFLD, research on the treatment modalities of NAFLD, and research on the risk factors and diagnosis methods of NAFLD. In recent years, the research emphasis in this field has changed, suggesting that future research will focus on two frontier keywords: “oxidative stress” and “aerobic capacity.”ConclusionIn the past eleven years, the attention in this field was still rising, and the authors, journals, countries and so on had formed a considerable cooperative relationship. There were also many highly influential and productive researchers in this field. It is speculated that new research will continue around “aerobic exercise” and “oxidative stress” in the future.

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“…Thus, NAFLD is no longer considered a single process but instead a disease caused by adipose tissue (AT) lipolysis ( 3 , 4 ), gut microbiota ( 5 , 6 ), and liver dysfunction ( 4 ). Moreover, NAFLD is affected by dietary factors, genetic factors, and other factors ( 7 , 8 ). The etiology of NAFLD is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation

Lian

Zhang

et al. 2023

Front. Endocrinol.

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IntroductionThe study aimed to explore the association of serum 25(OH)D3 and hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients and to determine whether the effect of vitamin D (VD) is mediated by activation of the peroxisome proliferator-activated receptor α (PPARα) pathway.MethodsThe study contained a case-control study, in vivo and in vitro experiments. A case-control study was conducted to compare serum parameters between NAFLD patients and controls and to evaluate the association of 25(OH)D3 and NAFLD. In vivo study, male Wistar rats were randomly divided into control and model groups, fed a standard chow diet and a high-fat diet (HFD), respectively, for 7 weeks to generate an NAFLD model. Then, the rats were treated with VD and a PPARα antagonist (MK886) for 7 weeks. Tissue and serum were collected and assessed by biochemical assays, morphological analysis, histological analysis, and western blot analysis. In vitro, HepG2 cells were incubated with oleic acid (OA) to induce steatosis, which was evaluated by staining. HepG2 cells were pretreated with MK886 followed by calcitriol treatment, and differences in lipid metabolism-related proteins were detected by western blot.ResultsNAFLD patients were characterized by impaired liver function, dyslipidemia, and insulin resistance. Serum 25(OH)D3 was negatively associated with alanine aminotransferase (ALT) in NAFLD. VD deficiency was a risk factor for patients with no advanced fibrosis. Adequate VD status (25(OH)D3 >20 ng/mL) had a protective effect in patients after adjustment for confounding variables. NAFLD rats showed hyperlipidemia with severe hepatic steatosis, systematic inflammation, and lower serum 25(OH)D3. VD treatment ameliorated hepatic steatosis both in NAFLD rats and OA-induced HepG2 cells. Further, MK886 inhibited the anti-steatosis effect of VD.ConclusionThe study revealed that an adequate VD level may act as a protective factor in NAFLD and that VD may alleviate hepatic steatosis via the PPARα signaling pathway.

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Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD

Cited by 3 publications

References 18 publications

Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD

Effect of Aerobic Exercise on Liver Tissue in Rats with NAFLD

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation

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