Effect of advanced maternal age on pregnancy outcomes: a single-centre data from a tertiary healthcare hospital

Kanmaz, Ahkam Göksel; İnan, Abdurrahman Hamdi; Beyan, Emrah; Ögür, Suriye; Budak, Adnan

doi:10.1080/01443615.2019.1606172

Cited by 40 publications

(47 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Table 3 shows the odds ratios of adverse pregnancy outcomes for maternal age regarding the age range of 18-24 years. This table highlights the results where the odds ratios of pregnancy outcomes increased "linearly" with maternal age (GH, GDM, and cesarean section) or increased to the plateau phase (ages [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] and then increased at the age of ≥40 (for LGA and macrosomia, and after adjustment also for SGA and LBW). The youngest age was associated with the highest odds ratios of PE and premature birth (also after adjustment).…”

Section: Effects Of Maternal Age On the Adverse Pregnancy Resultsmentioning

confidence: 87%

“…The association of older age with a higher risk of PE, FGR, stillbirth and placental ablution may suggest a relation of older age with placental dysfunction [3]. Higher age is associated with reduced beta-cell (pancreatic) function and impaired carbohydrate metabolism as well as insulin resistance [21,35]. All these changes (factors) may increase the risk of hypertension and diabetes in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…There is a general tendency for the average age of pregnant women to increase, including those women who become pregnant for the first time. Advanced maternal age (AMA) is usually defined as age 35 or more for the mother at the time of delivery of her baby [1]. Studies in European and American populations have shown that the percentage of pregnant women >35 years old has increased 4-8 times over the last 30-40 years [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

Lewandowska

Sajdak²,

Więckowska

et al. 2020

Nutrients

View full text Add to dashboard Cite

As mothers age, the risk of adverse pregnancy outcomes may increase, but the results so far are controversial and several issues remain unknown, such as the impact of maternal weight on the effects associated with older age. In a prospective cohort of 912 Polish women with singleton pregnancies (recruited in 2015–2016), we assessed the pregnancy outcomes depending on the mother’s age (18–24, 25–29, 30–34, 35–39, and ≥40 years). Women aged ≥35 years (vs. <35 years) were assessed in terms of body mass index (BMI). Multidimensional logistic regression was used to calculate the odds ratios (with 95% confidence intervals) of the pregnancy results. The risk profiles (using the Lowess method) were applied to determine the threshold risk. We found that both the youngest and the oldest group members displayed higher adjusted odds ratios of preeclampsia (PE), intrauterine growth restriction (IUGR), and preterm birth <37th week (U-shaped risk). In the remaining cases, the age ≥40 years, compared to the youngest age 18–24 years, was associated with a higher adjusted risk of gestational hypertension (GH) (AOR = 5.76, p = 0.034), gestational diabetes mellitus GDM-1 (AOR = 7.06, p = 0.016), cesarean section (AOR = 6.97, p <0.001), and low birth weight LBW (AOR = 15.73, p = 0.033) as well as macrosomia >4000 g (AOR = 8.95, p = 0.048). We found that older age ≥35 years (vs. <35 years) was associated with higher adjusted odds ratios of all the pregnancy outcomes investigated. In obese women, these adverse older age related results were found to be more intense in GH study, as well as (though weaker) in birth <37th week study, small-for-gestational age birth weight (SGA), LBW, large-for-gestational age birth weight (LGA), and macrosomia. In overweight women, these adverse older age related results were found to be more intense in preterm birth study, as well as (though weaker) in SGA and LBW. In underweight women, adverse pregnancy outcomes related to older age were more intense in a study of cesarean section. At the same time, underweight was associated with reversal of some negative effects of older age (we found lower odds ratios of GDM-1 diabetes). The maternal threshold age above which the risk of GH, PE, GDM, caesarean section, and preterm birth increased was 33–34 years (lower than the threshold of 35 years assumed in the literature), and the threshold risk of IUGR, LBW, SGA, LGA, and macrosomia was 36–37 years. Main conclusions: Older maternal age was associated with a higher chance of all kinds of obstetric complications. Older women should particularly avoid obesity and overweight.

show abstract

Section: Effects Of Maternal Age On the Adverse Pregnancy Resultsmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

Lewandowska

Sajdak²,

Więckowska

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Previous studies have reported that women with AMA had higher incidences of pregnancy complications, such as hypertensive disorders of pregnancy, gestational hypertension, placental disorders, preterm labor, maternal near miss, and maternal death [4][5][6][7]. Moreover, research also suggested that the elevated risks of pregnancy complications in AMA may differ by parity [8], and inconsistent results were reported regarding certain complications [9][10][11]. For instance, some studies found that the risk of gestational diabetes and hypertensive disorders of pregnancy were increased in both nulliparous and multiparous women with AMA [9], while in some studies the increased risks for the two complications were not observed in both nulliparas and multiparas [10,12].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy complications among nulliparous and multiparous women with advanced maternal age: a community-based prospective cohort study in China

Luo

Fan²,

Luo

et al. 2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background This study aimed to evaluate the incidence rates and risks of pregnancy complications among nulliparous and multiparous women with advanced maternal age (AMA, ≥35 years) in China. Methods We performed a community-based prospective cohort study of 10,171 pregnant women in selected two sub-districts and 11 towns of Liuyang from 2013 to 2015. All subjects were followed up from the first prenatal care (at ≤12 weeks) to delivery, and risks of pregnancy complications were compared by parity and maternal age groups. Results Among nulliparas, women with AMA showed significantly increased risks for gestational hypertension (OR 8.44, 95%CI 1.68–2.88), preeclampsia/eclampsia (OR 9.92, 95%CI 4.87–18.78), premature rupture of membrane (OR 6.84, 95%CI 2.00–17.69), as compared to women in the 20–29-year age group. Among multiparas with AMA, increased risks were found for gestational diabetes mellitus (OR 3.29, 95%CI 1.76–5.94), anemia (OR 1.85, 95%CI 1.25–2.69), polyhydramnios (OR 3.29, 95%CI 1.56–6.64), premature rupture of membrane (OR 5.14, 95%CI 2.12–12.29), and preterm labor (OR 1.89, 95CI 1.42–2.50). Conclusions Women with AMA were associated with increased risks of pregnancy complications, and complications with increased risks differed in nulliparas and multiparas. Women with AMA should be identified as a high-risk group in clinical practice.

show abstract

“…The findings of this study was generally consistent with the current literature. However, to the best of our knowledge, no study in the literature investigated merely the effect of maternal age on pregnancy outcomes (19)(20)(21)(22)(23). In our opinion this is the main strength of our study.…”

Section: Maternalmentioning

confidence: 77%

A Cut Off Value for Advanced Maternal Age in Predicting Adverse Obstetric and Neonatal Outcomes in Spontaneous Pregnancies

Ünal

Fadıloğlu

Halis

et al. 2020

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

View full text Add to dashboard Cite

Background: To define a cut off value for maternal age to predict adverse obstetric and neonatal outcomes in spontaneous pregnancies ≥40 years of age. Methods: We retrospectively evaluated 359 pregnant women ≥40 years of age. Patients were enrolled into two groups as Group 1 (40-43) and Group 2 (≥44). We compared the obstetric and neonatal adverse outcomes of the study groups. We also performed ROC curve analysis to predict adverse obstetric and neonatal outcomes in terms of maternal age. Results: Composite obstetric complication rate was significantly higher in group 2 (80.5%) than in group 1 (36.5%) (p < 0.001). Preeclampsia rate was also significantly more common in group 2 (p: 0.001). Admission to NICU was statistically significantly higher in group 2 (77.1%) compared to group 1 (28.7%) (p < 0.001). ROC curve analysis revealed 41.5 years of age as a cutoff value for predicting adverse neonatal outcomes and NICU admission (AUC: 0.607 and 0.566, respectively). Conclusion: Physicians should be cautious in the management of advence maternal age (AMA) pregnancies especially in patients with maternal age of ≥41.5 years.

show abstract

Effect of advanced maternal age on pregnancy outcomes: a single-centre data from a tertiary healthcare hospital

Cited by 40 publications

References 23 publications

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women

Pregnancy complications among nulliparous and multiparous women with advanced maternal age: a community-based prospective cohort study in China

A Cut Off Value for Advanced Maternal Age in Predicting Adverse Obstetric and Neonatal Outcomes in Spontaneous Pregnancies

Contact Info

Product

Resources

About