Pregnancy complications among nulliparous and multiparous women with advanced maternal age: a community-based prospective cohort study in China

Abstract

Background This study aimed to evaluate the incidence rates and risks of pregnancy complications among nulliparous and multiparous women with advanced maternal age (AMA, ≥35 years) in China. Methods We performed a community-based prospective cohort study of 10,171 pregnant women in selected two sub-districts and 11 towns of Liuyang from 2013 to 2015. All subjects were followed up from the first prenatal care (at ≤12 weeks) to delivery, and risks of pregnancy complications were compared by parity and maternal age groups. Results Among nulliparas, women with AMA showed significantly increased risks for gestational hypertension (OR 8.44, 95%CI 1.68–2.88), preeclampsia/eclampsia (OR 9.92, 95%CI 4.87–18.78), premature rupture of membrane (OR 6.84, 95%CI 2.00–17.69), as compared to women in the 20–29-year age group. Among multiparas with AMA, increased risks were found for gestational diabetes mellitus (OR 3.29, 95%CI 1.76–5.94), anemia (OR 1.85, 95%CI 1.25–2.69), polyhydramnios (OR 3.29, 95%CI 1.56–6.64), premature rupture of membrane (OR 5.14, 95%CI 2.12–12.29), and preterm labor (OR 1.89, 95CI 1.42–2.50). Conclusions Women with AMA were associated with increased risks of pregnancy complications, and complications with increased risks differed in nulliparas and multiparas. Women with AMA should be identified as a high-risk group in clinical practice.

Visual impairment and associated factors among pregnant women attending antenatal care units at health institutions in Gondar City Administration, Northwest Ethiopia

“…Multi and grand-multiparous pregnant women were more liable to develop VI than those who were nulli and primiparous. This finding is supported by a previous study in the USA [ 15 ], Croatia [ 23 ], and China [ 20 ]. This event is probably accounted for the repeated ocular alteration in the succeeding gravidity of mothers who had a greater number of parity.…”

“…According to the previous studies in the globe, VI has a cross relation with the age of pregnant women [ 1 , 14 , 15 ], residence [ 1 , 16 ], educational status [ 17 – 19 ], occupation [ 20 , 21 ], gestational age (GA) [ 7 , 15 , 22 ], maternal parity [ 15 , 20 , 23 ], diabetes mellitus [ 24 , 25 ], gestational diabetes mellitus (GDM) [ 14 , 20 ], pre-existing hypertension [ 12 , 20 ], pregnancy-induced hypertension (PIH) [ 14 , 20 ], family history of vision problem [ 26 ], prolonged use of smart phones and computers [ 27 – 29 ], medication history [ 14 , 30 , 31 ], and history of contraceptive use [ 14 , 32 ].…”

Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: a population‐based study

“…Luo et al identified the incidence rates of pregnancy complications in nulliparous and multiparous Chinese women of advanced maternal age using a community-based prospective cohort. The findings suggested that women of advanced maternal age should be regarded as at high risk for pregnancy complications, including HDP [ 19 ]. A large cohort of Japanese women with singleton pregnancies also indicated that advanced maternal age was a risk factor for HDP [ 10 ].…”

Pregnancy Patterns Impact Live Birth Rate for Patients With Intrauterine Adhesions After Hysteroscopic Adhesiolysis: A Retrospective Cohort Study

“…Therefore, the incidences of spontaneous abortion, ectopic pregnancy, stillbirth, and fetal chromosomal abnormalities in older pregnant women (≥35 years old) are also increased. The incidences of gestational diabetes mellitus, hypertensive disorder complicating pregnancy, abnormal amniotic fluid volume, placenta previa, postpartum hemorrhage, and multiple pregnancy are also significantly increased ( Lean et al, 2017 ; Luo et al, 2020 ).…”