Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study

Konishi, Sakae; Imai, Atsushi; Okita, Kazutaka; Kido, Koichi; Ozaki, Yusuke; Uemura, Nozomi; Iwane, Takuro; Okamoto, Teppei; Yamamoto, Hayato; Yoneyama, Takahiro; Hashimoto, Yasuhiro; Οhyama, Chikara

doi:10.1002/bco2.114

Cited by 5 publications

(2 citation statements)

References 33 publications

(99 reference statements)

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“…Matsumoto et al showed in a cross-sectional study of 1113 adults that the amount of advanced glycation end products (AGEs) measured by skin autofluorescence, surrogate markers of oxidative stress, were significantly associated with the frequency of nocturia [ 33 ]. Konishi et al found oxidative stress to be significantly associated with worsening sleep disorders, although not with worsening nocturia frequency [ 34 ]. It is known that NE and nocturia share common pathophysiology pathways [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria

et al. 2023

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Background Nocturnal enuresis (NE) is a common disease with multiple pathogenic mechanisms. This study aimed to compare levels of metabolites and proteins between wet and dry nights in urine samples from children with monosymptomatic NE (MNE). Methods Ten boys with MNE and nocturnal polyuria (age: 7.6 ± 1.3 years) collected their total nighttime urine production during a wet and a dry night. Untargeted metabolomics and proteomics were performed on the urine samples by liquid chromatography coupled with high-mass accuracy tandem mass spectrometry (LC-MS/MS). Results On wet nights, we found reduced urine osmolality (P = 0.025) and increased excretion of urinary potassium and sodium by a factor of, respectively, 2.1 (P = 0.038) and 1.9 (P = 0.19) compared with dry nights. LC-MS identified 59 metabolites and 84 proteins with significantly different levels between wet and dry nights (fold change (FC) < 0.67 or > 1.5, P < 0.05). Some compounds were validated by different methodologies. During wet nights, levels of compounds related to oxidative stress and blood pressure, including adrenalin, were increased. We found reduced levels of aquaporin-2 on wet nights. The FCs in the 59 metabolites were positively correlated to the FCs in the same metabolites identified in urine samples obtained during the evening preceding wet and dry nights. Conclusions Oxidative stress, which in the literature has been associated with nocturia and disturbances in sleep, might be increased during wet nights in children with MNE. We further found evidence of increased sympathetic activity. The mechanisms related to having wet nights in children with MNE seem complex, and both free water and solute handling appear to be important. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria

et al. 2023

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“…Switching to the field of functional urology, the paper by Konishi et al 7 investigated the effect of advanced glycation end products (AGEs) on nocturia and sleep disorders. The key background information includes the known associations between sleep disturbances and nocturia and adds emerging information on oxidative stress imbalance as a relation to nocturia.…”

Section: Figurementioning

confidence: 99%

Adapting to the long pandemic

Davis

2022

BJUI Compass

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Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study

Konishi

Imai²,

Okita

et al. 2021

BJUI Compass

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Objective: This study aimed to investigate the effect of advanced glycation end products (AGEs) on nocturia and sleep disorders in community-dwelling adults. Materials and Methods: This longitudinal study evaluated AGEs level, sleep disorders and nocturia frequency in 447 community-dwelling adults between May 2011 and May 2016. Sleep disorders were evaluated using the Pittsburgh Sleep Quality Index (PSQI) score. Participants were divided into two groups: AGEs-low (≤1.80) and AGEs-high (>1.80). The longitudinal nocturia and PSQI changes for 5 years between the AGEs-low and AGEs-high groups were compared. The effect of baseline oxidative stress on worsening of nocturia or PSQI score 5 years later was evaluated using multivariable logistic regression analyses.Results: There was no significant difference in PSQI score and nocturia frequency between the AGEs-low (n = 223) and AGEs-high (n = 224) groups at baseline. The PSQI score and nocturia frequency increased significantly over 5 years in both groups. However, the PSQI score increased significantly in the AGEs-high group compared with the AGEs-low group, although there was no difference in nocturia.Background-adjusted multivariable analysis showed that the AGE-high was significantly associated with PSQI score worsening, but AGE-high was not significantly associated with nocturia worsening.Conclusions: Oxidative stress may be significantly associated with worsening sleep disorders, although oxidative stress may not significantly worsen nocturia frequency.

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Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study

Cited by 5 publications

References 33 publications

Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria

Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria

Adapting to the long pandemic

Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study

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