Effect of adrenal function on level of hepatic and extrahepatic arginase

Mimic-Oka, Jasmina; Čupić, Željko; Japundzić, I

doi:10.1007/bf02154301

Cited by 5 publications

(7 citation statements)

References 8 publications

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“…Arginase activity in the rat liver decreases in response to adrenalectomy and increases in response to glucocorticoid treatment of adrenalectomized rats, 2,5,14,17 which shows that the in vivo level of glucocorticoids effects of vitamin e and se on arginase activity in glucocorticoid-treated rats 333 plays a major role in maintaining the internal milieu for arginase activity. 7,17 In vivo and in vitro studies using different glucocorticoids indicate that glucocorticoids increase the activity of liver arginase.…”

Section: Discussionmentioning

confidence: 95%

“…6,21,22 It has been established that glucocorticoids increase the activity of liver arginase. 1,7,14,17 The effects of glucocorticoids on arginase activity have only been investigated in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…Lower arginase activities are also found in extrahepatic tissues such as the kidney, heart muscle, intestine, lung, spleen, brain, and skeletal muscle. 9 The effects of various glucocorticoids on arginase activity have been studied in vivo in different species, 7,10-13 tissues [13][14][15][16][17] and age groups, 3,[16][17][18][19] and in vitro in explant 15,20 and cell cultures. 6,21,22 It has been established that glucocorticoids increase the activity of liver arginase.…”

Section: Introductionmentioning

confidence: 99%

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Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Erişir

Beytut

Özan

et al. 2003

Cell Biochemistry & Function

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The effects of dietary intake of vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of prednisolone were investigated. Rats were divided into five groups. Groups 3, 4, and 5 received a daily supplement in their drinking water of vitamin E, Se, and a combination of vitamin E and Se, respectively, for 30 days. For 3 days subsequently, the control group (group 1) was given a placebo, and the remaining four groups were injected intramuscularly with prednisolone. The tissue samples were collected from each group at 4, 8, 12, 24, and 48 h after the last administration of prednisolone. In the group treated with prednisolone alone, arginase activity in the liver was found to have increased at all the time periods, whereas it had decreased significantly in the heart at 48 h. Arginase activity in the kidneys was not affected by prednisolone. Compared to the control and prednisolone groups, arginase activity in the kidneys and heart of the vitamin E- and Se-supplemented groups was found to be significantly increased at all time periods, however, no difference was seen in the combination group. Arginase activity in the liver of the vitamin E-supplemented group was found to have decreased at all time periods, however, in the Se group compared to the prednisolone group it had reduced at 24 and 48 h only. In the combination group compared to the prednisolone group, liver arginase activity increased constantly up to 12 h returning to normal values at 48 h. Vitamin E and Se in combination may prevent the changes in arginase activity in various tissues caused by prednisolone.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Erişir

Beytut

Özan

et al. 2003

Cell Biochemistry & Function

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“…It has been established that glucocorticoids increase the activity of liver arginase (Mimic-Oka et al 1971;Kumar and K a lyankar 1984;Patnaik and Patnaik 1989;Grofte et al 1998). Different glucocorticoids have different effects on arginase in the kidney.…”

Section: Discussionmentioning

confidence: 99%

“…Park and Tappel (1991) reported a relationship between vitamin E and arginase: rats fed a vitamin E supplemented diet had a lower liver arginase activity than those fed a vitamin E deficient diet. Arginase is known to be inducible by hormones (Mimic-Oka et al 1971;Yamanaka et al 1971;Kumar and K a lyankar 1984;Patnaik and Patnaik 1989). This effect can be prevented by vitamin E. Therefore, we examined the effects of vitamin E supplementation on arginase activity in the liver and kidneys of testosterone-treated and castrated rabbits.…”

mentioning

confidence: 99%

Effect of Vitamin E Administration on Arginase Activity on the Liver and Kidneys of Testosterone-Treated and Castrated Rabbits

Erişir

Aydile²,

Aksakal³

2005

Acta Vet. Brno

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Erisir M., N. Aydilek, M. Aksakal: Effect of Vitamin E on Arginase Activity in the Liver and Kidneys of Testosterone-Treated and Castrated Rabbits. Acta Vet. Brno 2005, 74:527-531. In the present study we examined the effect of vitamin E administration on arginase activity in the liver and kidneys of testosterone-treated and castrated rabbits. Forty-six 3-month-old male rabbits were divided into six groups: 1) control rabbits, 0.5 ml olive oil; 2) testosterone-treated rabbits, 10 mg of testosterone propionate dissolved in 0.5 ml olive oil; 3) bilaterally castrated rabbits, 0.5 ml olive oil; 4) vitamin E-treated rabbits, 100 mg/kg dl-α-tocopheryl acetate dissolved in 0.5 ml olive oil; 5) vitamin E-and testosterone-treated rabbits, 100 mg/kg dl-α-tocopheryl acetate and 10 mg testosterone propionate dissolved in 0.5 ml olive oil; 6) bilaterally castrated and vitamin E-treated rabbits, 100 mg/kg dl-α-tocopheryl acetate dissolved in 0.5 ml olive oil. The administration was done subcutaneously over 24 h for 40 days; then the arginase activities in the liver and kidneys were determined.Liver arginase activities in all the groups did not change significantly (p > 0.05). Kidney arginase activities were not affected by castration and vitamin E. Kidney arginase activity was found to have increased two-fold by testosterone treatment. Testosterone-induced arginase activity in the kidneys returned to normal level with a significant lowering effect of the combination of vitamin E and testosterone.These results indicate that vitamin E supplementation has a significant reducing effect on the testosterone-induced arginase activity in the kidneys. Vitamin E ameliorates the testosteroneinduced arginase activity in the kidneys.

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Effect of caffeine on metabolism of L-arginine in the brain

Nikolić

Bjelaković

Stojanović

2003

Guanidino Compounds in Biology and Medicine

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Methylxanthines are widely consumed because of their stimulating effect primarily on the central nervous system. Their diuretic and respiratory stimulant action is used in clinical medicine. L-Arginine metabolism in the brain is very important for normal brain function. In addition to brain protein synthesis, arginine is a substrate for the production of urea, creatine, nitric oxide, agmatine, glutamic acid, ornithine, proline and polyamines. As known, many of these compounds are very important in brain function. There is no information relating to effects of caffeine on arginine metabolism in the brain, however, there is a lot of new information about arginine metabolism and caffeine action on the central nervous system. So, we have hypothesized the existence of a relationship that may be of interest in understanding mechanisms of caffeine effects on the central nervous system that may have utility in the clinical applications.In our experiment protocol we used male Wistar rats weighing about 200 g. Caffeine was added to the drinking water in gradually increasing amounts, from 2 gil over the first 3 days, to 4 gil over the last 7 days. A control group was given drinking water without caffeine. The level of lipid peroxidation, arginase and diarnine oxidase (DAO) activity in the brain was measured. The results of our study show that arginase and diamine oxidase were decreased in animals treated with caffeine. The level of lipid peroxidation (MDA) was decreased also.The inhibitory effect of caffeine on arginase activity indicates that caffeine provides more arginine for consumption in other metabolic pathways. Considering the central stimulant effects of caffeine and the decreased lipid peroxidation level, it can be assumed that moderate short-term consumption of caffeine may be beneficial for brain function. (Mol Cell Biochem 244: 125-128,2003)

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Effect of adrenal function on level of hepatic and extrahepatic arginase

Cited by 5 publications

References 8 publications

Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Effect of Vitamin E Administration on Arginase Activity on the Liver and Kidneys of Testosterone-Treated and Castrated Rabbits

Effect of caffeine on metabolism of L-arginine in the brain

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