Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Abstract

The effects of dietary intake of vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of prednisolone were investigated. Rats were divided into five groups. Groups 3, 4, and 5 received a daily supplement in their drinking water of vitamin E, Se, and a combination of vitamin E and Se, respectively, for 30 days. For 3 days subsequently, the control group (group 1) was given a placebo, and the remaining four groups were injected intramuscularly with prednisolone. The tissue samples were collected from each group at 4, 8, 12, 24, and 48 h after the last administration of prednisolone. In the group treated with prednisolone alone, arginase activity in the liver was found to have increased at all the time periods, whereas it had decreased significantly in the heart at 48 h. Arginase activity in the kidneys was not affected by prednisolone. Compared to the control and prednisolone groups, arginase activity in the kidneys and heart of the vitamin E- and Se-supplemented groups was found to be significantly increased at all time periods, however, no difference was seen in the combination group. Arginase activity in the liver of the vitamin E-supplemented group was found to have decreased at all time periods, however, in the Se group compared to the prednisolone group it had reduced at 24 and 48 h only. In the combination group compared to the prednisolone group, liver arginase activity increased constantly up to 12 h returning to normal values at 48 h. Vitamin E and Se in combination may prevent the changes in arginase activity in various tissues caused by prednisolone.

Effects of Aroclor 1254 and vitamin E on arginase activity in adult, pregnant rats and their offsprings

“…Some studies have proved that there were some relationships between vitamin E and arginase. Park and Tappel (25) reported that rats fed with a vitamin E supplemented diet for 40 days had lower liver arginase activity than those fed with a diet not containing vitamin E. Moreover, administration of dietary vitamin E caused a significant decrease in the liver arginase activity increased due to high doses of prednisolone in rats (12). We found in this study that administering vitamin E on rats simultaneously with Aroclor 1254 caused a decrease in liver arginase activity compared to the Aroclor 1254 group.…”

“…Park and Tappel (25) reported that rats fed with a vitamin supplemented diet had a lower liver arginase activity compared to those fed with a diet not containing vitamin E. Additionally, administration of dietary vitamin E caused a significant decrease in the liver arginase activity increased due to high doses of prednisolone in rats (12).…”

Influence of vitamin E and vitamin E‐selenium combination on arginase activity, nitric oxide level and some spermatological properties in ram semen

“…Although some relationships between spermatological parameters and seminal plasma arginase activity have been reported (Gür & Kandemir, ; Türk, Gür, Kandemir, & Sönmez, ), no evidence was found effect of vitamin E and/or vitamin E + selenium combination on seminal plasma arginase activity. However, in a study conducted by adding vitamin E and selenium to diet, a significant increase in cardiac and renal arginase activity and a decrease hepatic arginase activity was observed in vitamin E ingested group, but no difference was found in the vitamin E + selenium combination group compared to the control group (Erişir, Beytut, Ozan, & Aksakal, ). In another study, it has been suggested that arginase activity decrease in the tissues of rats fed with diet supplemented with vitamin E (Park & Tappel, ).…”

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“…Several studies indicated that there was a relationship between vitamins and arginase (Jekinson et al, 1996, Park et al, 1991. Erisir et al(2003) investigated the effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid. They found that vitamin E and Se in combination may prevent the changes in arginase activity in various tissues caused by prednisolone.…”

“…Vitamin E provides homeostasis in living cells. Several studies have indicated that there are relationships between vitamin E and arginase, and between arginase and selenium (Erisir et al, 2003). The determined amounts of vitamin E have been supplemented to diets to increase pleopodal egg number in crayfish, to modulate the antioxidant defense system and to provide optimum growth in prawn (Harlioglu and Barim., 2004, Dandapat et al, 2000, He and Lawrence, et al, 1993.…”