Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial

Yılmaz, İlkay; Dolar, Enver; Özpınar, Haydar

doi:10.5152/tjg.2018.18227

Cited by 114 publications

(104 citation statements)

References 37 publications

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“…In a clinical trial in 2018, Yilmaz et al assessed the effects of kefir consumption on the QOL of IBD patients. Compared to the control group, abdominal pain score (p = 0.049) and feeling good score (p = 0.019) were improved in the probiotic consuming group (Yılmaz et al 2019) . However, a similar analysis by Zocco et al showed no significant differences between the probiotic, and placebo-treated IBD patients (Zocco et al 2006).…”

Section: Accepted Articlementioning

confidence: 87%

“…Most probiotic products contain species from Lactobacillus and Bifidobacterium genera which modulate the gut microbial population and increase intestinal barrier function (Kleerebezem andVaughan, 2009, Li et al 2016). The effect of probiotics on the gut microbiota of patients has been reported (Marushko, 2013, Shadnoush et al 2015, Yılmaz et al 2019. Shadnoush in 2015, indicated that the consumption of the probiotic yogurt by IBD patients increases the number of helpful bacteria such as of Bifidobacterium and Lactobacillus, and decreases the stool load of Bacteroides (Shadnoush et al 2015).…”

Section: Accepted Articlementioning

confidence: 99%

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The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009–2020

Emamie

Rajabpour

Ghanavati³

et al. 2020

J Appl Microbiol

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Aims: To perform a systematic review on randomized controlled trials to examine the efficacy of probiotics, prebiotics and synbiotics in the treatment of IBD. Methods and Results: PubMed, Web of science, Scopus, and Google Scholar were systematically searched from January 2009 to January 2020 using the following keywords: "Inflammatory Bowel Disease", "Probiotics" and "Clinical trial". The statistical analysis was performed using SPSS software version 24.0. A total of 1,832 articles were found during the initial search and 21 clinical trials were eligible. Studies comparing the effects of probiotics and placebo among patients with active ulcerative colitis (UC) showed a significant difference in clinical outcomes. Moreover, Accepted Article This article is protected by copyright. All rights reserved probiotics improved the overall induction of remission rates among patients with Crohn's disease (CD). Probiotics significantly decreased the IL-1β, TNF-α and IL-8 levels. Also, the need for systemic steroids, hospitalization, surgery, as well as histological score and disease activity index significantly decreased in patients who used probiotic or pro-/synbiotics. Conclusions: The use of probiotics, as food supplements, can induce anti-inflammatory reactions, balance the intestinal homeostasis and induce remission in IBD. The efficacy of probiotics on remission induction is more reported in UC rather than CD. Larger well-designed clinical trials are needed to further determine whether probiotics are of clear benefits for remission in IBD.

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Section: Accepted Articlementioning

confidence: 87%

Section: Accepted Articlementioning

confidence: 99%

The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009–2020

Emamie

Rajabpour

Ghanavati³

et al. 2020

J Appl Microbiol

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“…We did not observe significant changes in the incidence of gastrointestinal symptoms, with the exception of significantly decreased sensation of bloating after kefir intervention. In most studies, consumption of kefir or other probiotics had beneficial effects on most gastrointestinal symptoms (Kato-Kataoka et al, 2016;Lee et al, 2018;Yılmaz et al, 2019). Stool consistency became softer after both kefir and milk intervention.…”

Section: Discussionmentioning

confidence: 99%

The effect of kefir and milk intake on intestinal permeability

Novak¹,

Pražnikar²,

Petelin³

2020

Zdravje Delovno Aktivne Populacije / Health of the Working-Age Population

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We performed a longitudinal intervention study that lasted 4 months at the UP Faculty of Health Sciences in Izola. The participants were divided into two groups, each alternately consuming kefir or milk for 21 days, with two washout periods in-between. Venous blood was sampled (fasted) after each phase and the participants completed a questionnaire on gastrointestinal symptoms and a Bristol stool scale. Kefir supplementation resulted in a greater improvement of serum zonulin levels whereas significant yet similar improvement in lipid profile, serum glucose levels, inflammation markers and appetite were found in both supplementations. We did not observe significant changes in the incidence of gastrointestinal symptoms, with the exception of significantly decreased sensation of bloating after kefir intake. The average number of defecations increased after kefir intake and decreased after milk intake. The percentage of participants who defecated at a consistent time each day decreased after kefir intake and increased after milk intake. We conducted one of the first studies comparing the effects of kefir and milk on the human intestine. Our research shows that daily kefir consumption could be an effective strategy for individuals with constipation and bloating. There is still a lack of solid evidence for the use of probiotics for most medical conditions.

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“…In patients with CD, there was a significant reduction in bloating (p=0.012) and improvement in feeling good scores (p=0.032) in the last two weeks, a decrease in CRP levels (p=0.015), and an increase in hemoglobin levels (p=0.024) at four weeks in the kefir group. They also found that the rate of feeling good score in CD was significantly more compared to UC (p=0.019) [14]. In a study by Bjarnason et al, 81 UC and 61 CD patients were randomized to receive either Symprove™ (Symprove Ltd, Farnham, UK) or placebo for four weeks.…”

Section: Efficacy Of Probiotics In Qol In Ibd Patientsmentioning

confidence: 99%

Probiotics in Inflammatory Bowel Disease: Are We Back to Square One?

Puvvada

Luvsannyam

Patel

et al. 2020

Cureus

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Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the alimentary tract whose incidence has been increasing over the past few years. Even though there is a complex interplay of several factors in the pathogenesis of IBD, a decrease in the diversity of intestinal microbiome is commonly found in patients. Extensive research is directed towards the alteration of this microbiome to improve the symptoms of IBD. Probiotics, prebiotics, antibiotics, and diet are studied in this regard extensively. Among them, probiotics have gained more interest as some of the studies showed them to be effective in decreasing gut inflammation in vitro and in vivo. Although there is no cure for IBD as of today, the available medications do decrease gut inflammation and help prolong remission and decrease relapse rates. But their side effects preclude their long-term use. Probiotics may be a ray of hope among IBD patients as they are apparently safe. This article reviews each of the available literature from the past 10 years to see if there is any certain role of probiotics in induction, maintenance of remission, prevention of relapse, and improvement in the quality of life in IBD patients.

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Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial

Abstract: Serum resolvin D1 levels as a marker of inflammation in constipation dominant irritable bowel syndrome

Cited by 114 publications

References 37 publications

The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009–2020

The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009–2020

The effect of kefir and milk intake on intestinal permeability

Probiotics in Inflammatory Bowel Disease: Are We Back to Square One?

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