Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma

Neoptolemos, John P.; Moore, Malcolm J.; Cox, Trevor F.; Valle, Juan W.; Palmer, Daniel H.; McDonald, Alexander C.; Carter, Ross; Tebbutt, Niall C.; Dervenis, Christos; Smith, David; Glimelius, Bengt; Charnley, Richard M.; Lacaine, François; Scarfe, Andrew G.; Middleton, Mark R.; Anthoney, Alan; Ghaneh, Paula; Halloran, Christopher M.; Lerch, Markus M.; Oláh, Attila; Rawcliffe, Charlotte L.; Verbeke, Caroline S.; Campbell, Fiona; Büchler, Markus W.; European Study Group for Pancreatic Cancer, for the

doi:10.1001/jama.2012.7352

Cited by 530 publications

(358 citation statements)

References 29 publications

(52 reference statements)

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“…For operable pancreatic cancers, the patients are usually treated with adjuvant chemoradiotherapy (Regine et al, 2008) in the United States and with chemotherapy (Neoptolemos et al, 2012) in Europe. Systematic therapy is the mainstay for metastatic pancreatic cancer (Tokh et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Racial and Social Economic Factors Impact on the Cause Specific Survival of Pancreatic Cancer: A SEER Survey

Cheung

2013

Asian Pacific Journal of Cancer Prevention

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Background: This study used Surveillance, Epidemiology and End Results (SEER) pancreatic cancer data to identify predictive models and potential socio-economic disparities in pancreatic cancer outcome. Materials and Methods: For risk modeling, Kaplan Meier method was used for cause specific survival analysis. The Kolmogorov-Smirnov's test was used to compare survival curves. The Cox proportional hazard method was applied for multivariate analysis. The area under the ROC curve was computed for predictors of absolute risk of death, optimized to improve efficiency. Results: This study included 58,747 patients. The mean follow up time (S.D.) was 7.6 (10.6) months. SEER stage and grade were strongly predictive univariates. Sex, race, and three socio-economic factors (county level family income, rural-urban residence status, and county level education attainment) were independent multivariate predictors. Racial and socio-economic factors were associated with about 2% difference in absolute cause specific survival. Conclusions: This study s found significant effects of socio-economic factors on pancreas cancer outcome. These data may generate hypotheses for trials to eliminate these outcome disparities.

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Section: Introductionmentioning

confidence: 99%

Racial and Social Economic Factors Impact on the Cause Specific Survival of Pancreatic Cancer: A SEER Survey

Cheung

2013

Asian Pacific Journal of Cancer Prevention

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“…However, IHCC, PHCC and DCC were grouped together in this study despite their obvious differences in anatomic location, etiopathogenesis, diagnosis, treatment and prognosis [6,11]. Furthermore, adjuvant therapy agents, doses and scheduling varied greatly among different literatures [12][13][14]. In addition, the clinical data of CCAs are usually collected over many years with a limited number of patients for the rarity of this disease, which inevitably lead to bias for the variability of diagnosis and treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

FBXW7 Pathway Functions as a Promising Therapeutic Target of Cholangiocarcinoma

Yang¹,

Chen²

2016

Chemotherapy

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“…The majority of the retrospective trials, which included limited sample sizes, heterogeneous patient populations and non-standardized therapies, suggested a marginal benefit of chemotherapy in reducing recurrence and an uncertain effect on survival (4,5). The only two prospective randomized controlled trials (RCT) currently available concluded that adjuvant chemotherapy did not improve survival (6,7).…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5-fluorouracil-based chemotherapy

Kim

Kwon

Kim

et al. 2013

Molecular and Clinical Oncology

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Abstract. Biliary tract cancer (BTC) is a relatively uncommon type of cancer, accounting for ~4% of the malignant neoplasms of the gastrointestinal tract. The aim of this study was to determine whether the expression of thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) predict clinical outcome in BTC patients treated with adjuvant 5-fluorouracil (5-FU)-based chemotherapy. TS and TP expression were found to be significantly correlated with cancer location (P=0.044 and 0.031, respectively). The multivariate analysis revealed that age [hazard ratio (HR)=2.157, P=0.008], stage (HR=2.234, P<0.001), resection margin status (HR=2.748, P=0.004) and TP expression (HR=2.014, P=0.039) were independently associated with overall survival (OS).

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Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma

Cited by 530 publications

References 29 publications

Racial and Social Economic Factors Impact on the Cause Specific Survival of Pancreatic Cancer: A SEER Survey

Racial and Social Economic Factors Impact on the Cause Specific Survival of Pancreatic Cancer: A SEER Survey

FBXW7 Pathway Functions as a Promising Therapeutic Target of Cholangiocarcinoma

Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5-fluorouracil-based chemotherapy

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