Cholesterol in the blood is a form of sterol derived from a lipid molecule that serves as the main structural component of plasma membrane. Atherosclerosis is a change characterized by thickening of the arterial walls due to the accumulation of cholesterol in the intima of blood vessels. By using SPSS analysis, it was found that the Shapiro-Wilk Normality Test with a sig value > 0.05, the data were normally distributed. The results of the analysis in the Test of Homogeneity of Variences table obtained a Sig Value 0.106. This the value of Sig = 0.106 > 0.05, them ho is accept. Thus the ethanol extract of ginger, pandan leaves, citronella, cinnamon, has the potential to reduce cholesterol levels. By using four different doses, the rat group at a dose 100mg/kgbw showed cholesterol levels of 90,75(mg/dl) ± 11,58, the rat group at a dose 200mg/kgbw showed cholesterol levels of 95,5(mg/dl) ± 6,80, the rat group at a dose 300mg/kgbw showed cholesterol levels of 75,75 (mg/dl)± 2,06, the rat group at a dose 400mg/kgbw showed cholesterol levels of 67,5mg/dl ± 2,64.