Effect of acute nitrogen dioxide exposure on the composition of fatty acid associated with phospholipids in alveolar lavage

Pulmonary surfactant: its isolation, characterization and function

“…(~~~~k $~ $fe~~s~~.i~~-~~ Gutkowski, p, phosgene (Frosolono & Currie, 1983), silica dust (Richards & Curtis, 1984), asbestos (Tetley et al, 1977), high oxygen (Lejman el al., 1983) and nitrogen dioxide (Kobayashi et al, 1984) all produce alterations in surfactant. These are review by Kikkawa & Smith (1983).…”

Does the Pulmonary Surfactant System Yield Meaningful Parameters in Inhalation Toxicity Studies? A Review

“…Arner et al found evidence for impairment of LLF surface activity as well as a reduction in the disaturated PC fraction (DPPC) in rats after exposure to 2.9ppm N02 for 9 months (Arner and Rhoades 1973). Exposure to N02 for 1-40 h did not result in a change (Kobayashi et al 1980;Leung 1983) or increase in synthesis rates of lung phospholipids (Blank et al 1978(Blank et al , 1982. Blank et al (1978) found a dose-dependent increase in total lung phospholipids in rats 2-3 days after the end of the N02 exposure (40ppm, Sh).…”

Effects of Environmental Factors on the Lung Surfactant System

“…When rats were exposed nitrogen dioxide atmospheres of 20 ppm for 20 and 4 hours, only slight changes in the phospholipid pool size of lung tissue resulted. 71 Dowell et al 56 reported that after nitrogen dioxide exposure the decrease in palmitic acid content of phosphatidylcholine was compensated for by an increase in the unsaturated fatty acids, mainly C-18 fatty acids. Conflicting results were obtained from Leung, 2 who reported unchanged levels of unsaturated fatty acids in phosphatidylcholine after exposure.…”