Effects of Environmental Factors on the Lung Surfactant System

Müller, Bernd

doi:10.1055/s-2007-1009816

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Lungenveränderungen Bei Covid-19 -Störung Des Pulmonalen Sur1

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Cited by 2 publications

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“…Surfactant, das in den Typ-II-Zellen in den Alveolen direkt gebildet wird. Eine Vielzahl von experimentellen Untersuchungen hat seit langem gezeigt, dass bei Lungenschädigungen, etwa durch inhalativ-toxische Gase, die Surfactantsubstanzen sich in Zusammensetzung und Funktion ändern [1]. Beim ARDS sind Veränderungen des Surfactants schon in den ersten Publikationen [2] diskutiert und später nachgewiesen worden [3,4].…”

Section: Lungenveränderungen Bei Covid-19 -Störung Des Pulmonalen Surunclassified

Lungenveränderungen bei COVID-19 – Störung des pulmonalen Surfactants?

Wichert

2020

Med Klin Intensivmed Notfmed

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Section: Lungenveränderungen Bei Covid-19 -Störung Des Pulmonalen Surunclassified

Lungenveränderungen bei COVID-19 – Störung des pulmonalen Surfactants?

Wichert

2020

Med Klin Intensivmed Notfmed

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Toxic oxidant species and their impact on the pulmonary surfactant system

Putman

Golde

Haagsman

1997

Lung

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In this review the effects of oxidant inhalation on the pulmonary surfactant system of laboratory animals are discussed. Oxidant lung injury is a complex phenomenon with many aspects. Inhaled oxidants interact primarily with the epithelial lining fluid (ELF), a thin layer covering the epithelial cells of the lung which contains surfactant and antioxidants. In the upper airways this layer is thick and contains high levels of antioxidants. Therefore oxidant injury in this area is rare and is more common in the lower airways where the ELF is thin and contains fewer antioxidants. In the ELF oxidants can react with antioxidants or biomolecules, resulting in inactivation of the biomolecules or in the formation of even more reactive agents. Oxidation of extracellular surfactant constituents may impair its function and affect breathing. Oxidized ELF constituents may promote inflammation and edema, which will impair the surfactant system further. Animal species differences in respiratory tract anatomy, ventilatory rate, and antioxidant levels influence susceptibility to oxidants. The oxidant exposure dose dictates injury, subsequent repair processes, and tolerance induction.

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Effects of Environmental Factors on the Lung Surfactant System

Cited by 2 publications

References 52 publications

Lungenveränderungen bei COVID-19 – Störung des pulmonalen Surfactants?

Lungenveränderungen bei COVID-19 – Störung des pulmonalen Surfactants?

Toxic oxidant species and their impact on the pulmonary surfactant system

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