Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery

Hashimoto, Masayoshi; Kim, Seungbum; Eto, Masato; Iijima, Katsuya; Ako, Junya; Yoshizumi, Masao; Akishita, Masahiro; Kondo, Kazuo; Itakura, Hiroshige; Hosoda, Kazuaki; Toba, Kenji; Ouchi, Yasuyoshi

doi:10.1016/s0002-9149(01)02137-3

Cited by 148 publications

(109 citation statements)

References 16 publications

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“…The significant increase in acute FMD following consumption of the polyphenol-rich drink is consistent with other studies conducted in non-athlete populations [16][17][18][19]. For instance, FMD was increased after consumption of 477 mg of polyphenols from non-alcoholized red wine in healthy subjects [18].…”

Section: Study 1-polyphenols and Fmdsupporting

confidence: 89%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

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Abstract:We examined how intake of polyphenols modifies brachial artery flow-mediated dilation (FMD) at rest, and cycling anaerobic performance, in elite athletes. In the first randomized cross-over study, FMD was measured over a three-hour period on two occasions in eight elite male and female athletes after acute consumption of either polyphenols from cranberries and grape seeds (600 mg) or a polyphenol-free placebo drink. Consumption of the polyphenol-rich drink led to a significant increase in FMD compared to placebo (p = 0.02), with a peak at 60 min. In a second study, 12 elite male and female athletes completed a threekilometer time trial (TT) on an ergocycle on two occasions in random order, either after consumption of 800 mg of polyphenols or a placebo. Acute intake of the polyphenol extract had no impact on the three-kilometer time trial completion. However, plasma lactate levels were significantly lower before and after the TT when subjects consumed the polyphenols vs. placebo (p < 0.05). Results suggest that polyphenols from cranberries and grape seeds acutely modifies FMD at rest in elite athletes but this does not translate into enhanced cycling anaerobic performance. OPEN ACCESSSports 2013, 1 56

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Section: Study 1-polyphenols and Fmdsupporting

confidence: 89%

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Labonté

Couillard

Motard-Belanger

et al. 2013

Sports

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“…Similar outcomes have been demonstrated in the literature with the use of red wine and grape juice in previously health men 27 . However, in this study the use of substances present in the drinks in question were evaluated and not only resveratrol.…”

Section: Effects Of Interventionssupporting

confidence: 84%

Use of Resveratrol in Cardiovascular Diseases Prevention: A Systematic Review

Góes

Fraga

Ladeia

2017

BJMHH

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| Resveratrol, a polyphenolic compound found in blackberry and red wine, has properties that prevent the development of atherosclerosis, and therefore, cardiovascular disease. The aim of this study was, through a systematic review, to assess whether resveratrol reduces the incidence of cardiovascular events and improves inflammation and endothelial dysfunction in individuals at risk. Searches were conducted in databases such as LILACS, PubMed,SCIELO and selected randomized controlled trials in humans, including the use of resveratrol in the prevention of cardiovascular events or in the improvement of inflammation and endothelial function. The final sample consisted of 10 items. Of the four studies that analyzed the flow-mediated dilatation of the brachial artery, all showed significant improvement in endothelial function after the use of resveratrol, compared with placebo. In the 7 studies that evaluated subclinical inflammation, there were differences, 3 studies showed significant decreases in the values of TNF-α, 2 showed significant changes in plasma levels of C-reactive protein and interleukin 6 (IL-6), while 1 didn't showed changes in TNF-α and IL-6. In conclusion, resveratrol is capable of improving endothelial function when compared with placebo. However, it was not possible to infer an improvement or not in the parameters concerning endothelial inflammation, since the data extracted from the studies were insufficient. Moreover, it was not possible to evaluate the use of resveratrol in the improvement of survival, infarction or reduction in mortality, since there were no records in the literature of randomized controlled trials that analyzed the effect of resveratrol use on clinical outcomes in humans.

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“…On the other hand, Hashimoto et al (36) demonstrated that endothelium-dependent vasodi-lation improves after acute intake (120 min) of RW or RW without alcohol in men. But endothelium-independent vasodilation remained unchanged.…”

Section: Discussionmentioning

confidence: 99%

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

Coimbra

Lage

Brandizzi

et al. 2005

Braz J Med Biol Res

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Although red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (ICAM-1 and VCAM), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. Twenty-four normal subjects were used as controls for vascular reactivity. Subjects randomly received RW, 250 ml/day, or purple grape juice (GJ), 500 ml/day, for 14 days with an equal wash-out period. At baseline, all 16 subjects were hypercholesterolemic (mean LDL = 181.0 ± 28.7 mg/dl) but HDL, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. Brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; P < 0.05) and increased with both GJ (10.1 ± 7.1 before vs 16.9 ± 6.7% after: P < 0.05) and RW (10.1 ± 6.4 before vs 15.6 ± 4.6% after; P < 0.05). RW, but not GJ, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; P < 0.01). GJ reduced ICAM-1 but not VCAM and RW had no effect on either molecule. No significant alterations were observed in plasma lipids, glucose or platelet aggregability with RW or GJ. Both RW and GJ similarly improved flow-mediated dilation, but RW also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. Thus, we conclude that GJ may protect against coronary artery disease without the additional negative effects of alcohol despite the gender.

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Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery

Cited by 148 publications

References 16 publications

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Acute Effects of Polyphenols from Cranberries and Grape Seeds on Endothelial Function and Performance in Elite Athletes

Use of Resveratrol in Cardiovascular Diseases Prevention: A Systematic Review

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

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