Effect of Acute Hypoxia on Blood TSH Levels

Hm, Curbelo; Ec, Karliner; Ab, Houssay

doi:10.1055/s-0028-1092699

Cited by 5 publications

(6 citation statements)

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“…Persistent effects after normalization of oxygen supply and thereby independent from catecholamine influences or alterations in energy supply were not investigated. Furthermore, one of the main factors regulating REE is the hypothalamic-pituitary-thyroid (HPT) axis [13,14], which has been found to be suppressed by hypoxia [15][16][17][18][19][20]. We hypothesized that REE decrease is preserved after acute hypoxia had ended, indicating a persistent metabolic adaptation independent of acute stress hormonal activation possibly mediated by suppression of the HPT axis.…”

Section: Introductionmentioning

confidence: 97%

Persistent suppression of resting energy expenditure after acute hypoxia

et al. 2006

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Section: Introductionmentioning

confidence: 97%

Persistent suppression of resting energy expenditure after acute hypoxia

et al. 2006

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“…Such asphyxiated newborns compared with the normal new-borns for mean level of thyroid hormone in the cord blood at birth and venous blood 18-24 hours after birth. There was no significant difference observed for the level of thyroid hormones between the groups in the cord blood while at 18-24 hours after birth there was significant decrease in all T 3 , T 4 and TSH was observed in asphyxiated newborns. Which suggest low level of T 3 and T 4 are secondary to low TSH concentration.…”

mentioning

confidence: 82%

“…Immediately after birth, umbilical cord was clamped at two different sites and blood was collected for analysis and determination of T 3 , T 4 and TSH. After 18 to 24 hours of birth, venous blood sample was collected for levels of thyroid hormones of each new-born in both groups (cases and controls).…”

Section: Methodsmentioning

confidence: 99%

“…[3][4][5][6][7][8]24 Effect of hypoxia on thyroid indices in term new-born have also been evaluated with conflicting results. [8][9][10] For the development of central nervous system thyroid hormone plays a pivotal role.…”

Section: Introductionmentioning

confidence: 99%

“…Tahivoric HF et al studied the serum concentration of thyroid hormone levels (T 4, fT 4 , rT 3 , T 3 , TSH and TBG) in cord blood at birth and serum on 5th day of life he concluded that neither hypoxia nor the method of delivery had any influence on the peripheral metabolism of thyroid hormones. In this study we matched both the groups with respect to gestational age, mother's age and thyroid status, baby's sex, birth weight, type of delivery, ethnic group and parity of mother so that the maximum difference was in exposure to birth asphyxia and probability of confounding bias could be minimized.…”

mentioning

confidence: 99%

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Effect of perinatal asphyxia on level of thyroid hormones in term neonates

Prabhakar

Agrawal

Jain

et al. 2016

Int J Contemp Pediatr

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INTRODUCTIONPerinatal asphyxia is the one of major public health problem in the world. It is the major cause of morbidity and mortality. It accompanies one of the three most common causes of death along with prematurity and bacterial infections.1 It causes decreased perfusion to the tissues causes diving seal reflex which causes shunting of blood away from lung, kidney, GIT, skin to brain, adrenals and heart.2 Cellular dysfunction occurs as a result of diminished oxidative phosphorylation and ATP production. Impaired oxidative phosphorylation can occur during the primary hypoxic ischemic insults as well as during a secondary energy failure that usually occurs approximately 6 to 24 hours after the initiating insult.Cell death can be either immediate or delayed, and either necrotic or apoptotic.In hypoxic adults and older children effect of hypoxia on thyroid metabolism has been studied. [3][4][5][6][7][8]24 Effect of hypoxia on thyroid indices in term new-born have also been evaluated with conflicting results. [8][9][10] For the development of central nervous system thyroid hormone plays a pivotal role. In non-thyroidal illnesses low level of thyroid hormones are associated with poor prognosis. The present study was conducted to evaluate the effect of perinatal asphyxia on level of thyroid hormones by comparing thyroid profile in cord blood and venous blood at 18-24 hour after birth in new-borns with and without asphyxia. ABSTRACT Background:To evaluate how perinatal asphyxia alters the thyroid function in term newborn by comparing cord blood and 18-24 hours venous blood in between newborns with and without asphyxia. Methods: A prospective case-control study was carried out at Tertiary care pediatric center in central India. 60 Full term newborn with perinatal asphyxia requiring bag and mask ventilation for ≥1 minute or APGAR at 1 and 5 minute ≤7 or required intubation for resuscitation as cases and control -60 normal term newborn with APGAR ≥7 at 1 and 5 minute were selected. Cord blood and 18 to 24 hour after birth venous blood were collected in both groups and compared for level of thyroid hormones (T3, T4, TSH) via radioimmunoassay. Results: There was no significant difference observed in cord blood thyroid hormones (P>0.05). But a significant lower level of thyroid hormones observed in asphyxiated group as compared to control group in venous sample 18-24 hours after birth [mean± standard deviation; T3 case=68.87 ± 21.08, T3 control=79.93 ± 20.52, P=0.004; T4 case 6.48 ± 2.41, T4 control=8.89 ± 1.46, P<0.001; TSH case=4.33 ± 4.36; TSH control=8.45 ± 1.70, P<0.001]. Conclusions: Perinatal asphyxia depresses the TSH level which further leads to decrease in T3 and T4 suggestive of central hypothyroidism.

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Endocrine Adaptation to Hypoxia

Raff

1996

Comprehensive Physiology

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Effect of Acute Hypoxia on Blood TSH Levels

Cited by 5 publications

References 6 publications

Persistent suppression of resting energy expenditure after acute hypoxia

Persistent suppression of resting energy expenditure after acute hypoxia

Effect of perinatal asphyxia on level of thyroid hormones in term neonates

Endocrine Adaptation to Hypoxia

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