Effect of acute ethanol and acute allopregnanolone on spatial memory in adolescent and adult rats

Differences in Behavioral Responding in Adult and Aged Rats Following Chronic Ethanol Exposure

“…Our results demonstrate that allopregnanolone impairs spatial memory in adult rats as previously reported (Chin et al, 2011;Matthews et al, 2002). However, contrary to our hypotheses, aged rats showed only a nonsignificant trend toward impairment when administered allopregnanolone.…”

“…After a 14-day EtOH-free period, animals were trained to locate a submerged platform in a fixed location of the Morris water maze (MWM) during 4 learning trials per day for 6 days, as previously described (Chin et al, 2011). Latency, path length, swim speed, and thigmotaxis were recorded using the HVS Image 2100 Plus tracking system (Buckingham, UK).…”

“…As aged animals show greater EtOH-induced memory impairments, age-related differences to EtOH's cognitive-impairing effects may be mediated in part in response to allopregnanolone. In adult and adolescent rats, acute allopregnanolone impairs spatial memory in a dose-dependent fashion (Chin et al, 2011;Matthews et al, 2002). However, the role of allopregnanolone in age-related differences to EtOH-induced cognitive impairments has not been examined in aged animals.…”

The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats

“…Animals were individually housed and given ad libitum access to food and water M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 7 throughout the experiment. Following previously published methods, all rats acclimated to the colony room for 2 days before any experimental procedures (Chin et al, 2011;Novier, Van Skike, Chin, Diaz-Granados, & Matthews, 2012;Novier et al, 2013;Silvers et al, 2006;.…”

Alterations in the hippocampal phosphorylated CREB expression in drug state-dependent learning

“…Ethanol administration has been reported to impair cognitive functions [13,14] through GABA A [15] and NMDA [16] receptors that exist in high proportions in the hippocampus. In addition, previous studies have highlighted the role of cAMP signaling pathway and the augmentation of CREB levels in ethanol tolerance and dependence [17,18].…”