Effect of acute and chronic administration of progesterone, estrogen, FSH and LH on oxidant and antioxidant parameters in rat gastric tissue

Kumtepe, Yakup; Borekci, Bunyamin; Karaca, Mehmet; Salman, Süleyman; Hakan, Hamit; Süleyman, Halis

doi:10.1016/j.cbi.2009.08.016

Cited by 27 publications

(17 citation statements)

References 35 publications

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“…Increasing lipid peroxidation production is an important cause of NSAIDs' damaging effects on stomach tissue [33]. Earlier studies have shown that gastric damage causes an increased MDA level [34].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Albayrak¹,

Hakan²,

Süleyman³

2015

EAJM

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Objective: Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A (MAO) enzyme selectively. When it is compared to the classic antidepressants drugs, moclobemide is the first choice in depression treatment because of its effectiveness and less side effects. This study aimed to investigate the antiulcer effects of moclobemide and to determine its relationship with antioxidant mechanisms in rat gastric tissue. Materials and Methods:The antiulcer activities of 10, 20, 40, 80, 150 mg/kg moclobemide and 20 mg/kg famotidine have been investigated on indomethacin-induced ulcers in rats, and the results have been compared with that of the control group. Results:Moclobemide decreased the indomethacin-induced ulcers significantly at all doses used. While used doses of moclobemide increased the glutathione (GSH), nitric oxide (NO) level and superoxide dismutase (SOD) activity, it decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in stomach tissue when compared to the control group. Conclusion:It is determined that an antidepressant drug, moclobemide is a potent anti-ulcer agent. Inhibition of toxic oxidant radicals and activation of antioxidant mechanisms play a role in its antiulcer effect mechanisms.

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Section: Discussionmentioning

confidence: 99%

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Albayrak¹,

Hakan²,

Süleyman³

2015

EAJM

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“…These are in turn known to be neural antagonists of gastrointestinal motility11–13 and absence of these hormones could explain the improvements seen. The effect on the gastrointestinal tract demands receptors for the substance, and receptors for progesterone and estrogen have been described in the gastrointestinal tract 14,15. The luteinizing hormone (LH) receptor was first described in gonadal tissues.…”

Section: Introductionmentioning

confidence: 99%

Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility

Hammar

Veress

Montgomery

et al. 2012

Drug Target�Insights

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Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients with and without severe dysmotility were examined using immunohistochemistry staining. Biopsies showed expression of LH receptors on myenteric neurons and in glial cells, neutrophils, endothelial cells and mast cells. There was no difference in expression between patient groups.

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“…Estrogen, seemingly protecting against LPO, could be exerting its potential antioxidant preventing oxidative damage and oxidative stress, as previously demonstrated (2,5,18,28) , through its hydrophenolic radicals (27) . Regarding antioxidant enzymes, SOD and CAT showed similar activity across the groups.…”

Section: Histologymentioning

confidence: 81%

“…Borekci et al (18) demonstrated the protection of estrogen in the gastric mucosa, as other authors have demonstrated the greatest protection in the cardiovascular system in women of reproductive age compared with men the same age, for their hormonal and antioxidant activity (3,12,13,17,27) . Intact or castrated female rats were subjected to PPVL (pre-hepatic model) and then analyzed regarding the influence of castration (absence of estrogen) in PH-related changes, mainly to PHG.…”

Section: Discussionmentioning

confidence: 93%

Protection of estrogen in portal hypertension gastropathy: an experimental model

Morgan-Martins

Jacques

Hartmann

et al. 2011

Arq. Gastroenterol.

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-Context -Portal hypertension is a complication secondary to cirrhosis that is characterized by increased blood flow and/or vascular resistance in the portal system, causing the appearance of a hyperdynamic collateral circulation. Partial portal vein ligation is an experimental model used in rats to study the pathophysiological mechanisms involved in pre-hepatic portal hypertension. Estrogen E2 is an antioxidant molecule with various physiological actions. Objectives -To evaluate the antioxidant activity of endogenous estrogen in an experimental model of partial portal vein ligation by comparing intact with castrated rats. Methods -Twenty Wistar rats, weighing on average 250 g were used and divided into four groups: sham-operated (SO); intact (I) with partial portal vein ligation (I + PPVL), castrated (C) and castrated with partial ligation of the vein (C + PPVL). Day 1: castration or sham-operation; day 7, PPVL surgery; on day 15 post-PPVL, portal pressure in the mesenteric vein of rats was measured on polygraph Letica. Lipid peroxidation in the stomach was assessed using the technique of thiobarbituric acid reactive substances and activity of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase. Statistical analysis was done with ANOVA -Student-NewmanKeuls (mean ± SE), and P<0.05 was considered as significant. Results -Portal pressure was significantly increased in C + PPVL as compared to the other groups. There was no significant difference in the group of intact rats. TBARS showed significant damage in C and C + PPVL in relation to others. Antioxidant enzymes were significantly increased in the castrated rats with subsequent PPVL as compared to the other groups. Conclusion -We suggest that estrogen E2 plays a protective role in intact compared with castrated rats because it presents hydrophenolic radicals in its molecule, thus acting as an antioxidant in this experimental model.

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Effect of acute and chronic administration of progesterone, estrogen, FSH and LH on oxidant and antioxidant parameters in rat gastric tissue

Cited by 27 publications

References 35 publications

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility

Protection of estrogen in portal hypertension gastropathy: an experimental model

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