“…Nicotine induces vasoconstriction, alters placental blood flow and causes oxygen deprivation in the fetus [26]. The effects of pregnant active smoking during pregnancy on fetal outcomes are trimester and dose dependent, and may increase the risk of adverse health effects on the fetus such as lower Apgar scale results, smaller head circumference [27], gastrointestinal defects (gastroschisis, ventral, umbilical or inguinal hernia), heart, cardiovascular and muscleskelectal defects, craniosynostosis, oral cleft, eye anomalies, limb reduction defects, digit anomaly and clubfoot, cryptorchidism [7] [24] and significantly blunted response to treatment with inhaled corticosteroids in children who subsequently develop asthma [26] [28] [29]. In response to fetal smoke exposure occurs increased arterial resistance with left atrium and aortic root development in post natal life [30] and structural and functional changes in the central nervous system [31].…”