Effect of Acid Pump Antagonist (Revaprazan, Revanex®) on Result of<sup>13</sup>C Urea Breath Test in Patients with<i>Helicobacter pylori</i>Associated Peptic Ulcer Disease

Oak, Ju Hyun; Chung, Woo Chul; Jung, Sung Hoon; Choi, Kyu-Yong; Kim, Eun Jung; Kang, Bong Koo; Kang, Bo Rami; Kong, Si Eun; Paik, Chang Nyol; Lee, Kang Moon

doi:10.4166/kjg.2011.57.1.8

Cited by 5 publications

(2 citation statements)

References 28 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…H. pylori detection in our study was based on histological and immunostaining methods. Other studies utilizing UBT as the main method of detecting H. pylori revealed false UBT-negative results in around one-third of patients [4,5,17,18] . Dickey et al [19] concluded in their study that PPI use before endoscopy was associated with lower sensitivity of antral and corpus biopsies for the detection of H. pylori using both urease testing and histological examination.…”

Section: Discussionmentioning

confidence: 99%

Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Nasser

Slim

Nassif

et al. 2015

WJG

View full text Add to dashboard Cite

AIM:To investigate the influence of proton pump inhibitors (PPIs) exposure on the diagnosis of Helicobacter pylori (H. pylori) gastritis and intestinal metaplasia. METHODS:Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed (H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System. RESULTS:Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old (range: 20-87). The histological types of gastritis were classified as H. pylori gastritis (n = 156, 52%) and non-H. pylori gastritis (n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure (71% vs 34.2%, P < 0.001). Intestinal metaplasia ORIGINAL ARTICLE Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes Retrospective StudySoumana C Nasser, Mahmoud Slim, Jeanette G Nassif, Selim M Nasser

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Nasser

Slim

Nassif

et al. 2015

WJG

View full text Add to dashboard Cite

show abstract

“…It can be used before therapy and to confirm eradication . One of the limitations of the UBT is the possibility of false negative results in the following conditions: 1, use of proton‐pump inhibitors (PPI), antibiotics, or bismuth 2 weeks before the test ; 2, UBT carried out <4 weeks after finishing a course of eradication ; and 3, gastric resection . So even if UBT is an excellent test when performed correctly in research protocols, we wanted to see how it performs in clinical practice and whether its accuracy could be affected by protocol violations.…”

mentioning

confidence: 99%

Helicobacter Pylori Breath Testing in an Open Access System has a High Rate of Potentially False Negative Results due to Protocol Violations

et al. 2012

View full text Add to dashboard Cite

show abstract

Non-invasive diagnostic tests forHelicobacter pyloriinfection

Best

Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

153

130

View full text Add to dashboard Cite

In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

show abstract

Effect of Acid Pump Antagonist (Revaprazan, Revanex®) on Result of¹³C Urea Breath Test in Patients withHelicobacter pyloriAssociated Peptic Ulcer Disease

Abstract: False negative results of UBT were common and increased with prolonged use of acid pump antagonist. As PPI, it had also anti-urease activity and most patients (47/52, 90.4%) reverted to positive results by 2 weeks after the cessation of taking the medication.

Cited by 5 publications

References 28 publications

Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Helicobacter Pylori Breath Testing in an Open Access System has a High Rate of Potentially False Negative Results due to Protocol Violations

Non-invasive diagnostic tests forHelicobacter pyloriinfection

Contact Info

Product

Resources

About

Effect of Acid Pump Antagonist (Revaprazan, Revanex®) on Result of13C Urea Breath Test in Patients withHelicobacter pyloriAssociated Peptic Ulcer Disease

Abstract: False negative results of UBT were common and increased with prolonged use of acid pump antagonist. As PPI, it had also anti-urease activity and most patients (47/52, 90.4%) reverted to positive results by 2 weeks after the cessation of taking the medication.

Cited by 5 publications

References 28 publications

Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Helicobacter Pylori Breath Testing in an Open Access System has a High Rate of Potentially False Negative Results due to Protocol Violations

Non-invasive diagnostic tests forHelicobacter pyloriinfection

Contact Info

Product

Resources

About

Effect of Acid Pump Antagonist (Revaprazan, Revanex®) on Result of¹³C Urea Breath Test in Patients withHelicobacter pyloriAssociated Peptic Ulcer Disease