Effect of Acetic Acid on Bacteriocin Production by Gram-Positive

Ge, Jingping; Kang, Jie; Ping, Wenxiang

doi:10.4014/jmb.1905.05060

Cited by 32 publications

(20 citation statements)

References 62 publications

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“…cyclic peptides formed by the ligation of their N-terminus to the C-terminus via an amide bond [20] Bacteriocin synthesis is meticulously regulated, producing premature peptides with a leader sequence at the N-terminus. These toxic peptides are secreted in the bacterial logarithmic growth phase with increasing bacterial numbers promoting increasing peptide secretion [19]. Secretion is influenced by environmental factors including bacterial cell density, nutrient availability, the presence of acetic acid, and signalling peptides (competence stimulating peptide molecules).…”

Section: Bacteriocinsmentioning

confidence: 99%

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Slattery²,

2020

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Despite highly specialized international interventions and policies in place today, the rapid emergence and dissemination of resistant bacterial species continue to occur globally, threatening the longevity of antibiotics in the medical sector. In particular, problematic nosocomial infections caused by multidrug resistant Gram-negative pathogens present as a major burden to both patients and healthcare systems, with annual mortality rates incrementally rising. Bacteriocins, peptidic toxins produced by bacteria, offer promising potential as substitutes or conjugates to current therapeutic compounds. These non-toxic peptides exhibit significant potency against certain bacteria (including multidrug-resistant species), while producer strains remain insusceptible to the bactericidal peptides. The selectivity and safety profile of bacteriocins have been highlighted as superior advantages over traditional antibiotics; however, many aspects regarding their efficacy are still unknown. Although active at low concentrations, bacteriocins typically have low in vivo stability, being susceptible to degradation by proteolytic enzymes. Another major drawback lies in the feasibility of large-scale production, with these key features collectively limiting their current clinical application. Though such limitations require extensive research, the concept of expanding bacteriocins from food preservation to human health opens many fascinating doors, including novel drug delivery systems and anticancer treatment applications.

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Section: Bacteriocinsmentioning

confidence: 99%

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Slattery²,

2020

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“…Bacteriocins of Gram-negative bacteria are divided into four main classes: colicins, colicin-like, phage-tail-like bacteriocins, and microcins [ 17 ]. Colicins are protease-sensitive, heat-sensitive high-molecular weight (30–80 kDa) bactericidal proteins synthesized by most E. coli strains that have a single colicinogenic plasmid.…”

Section: Classification Of Bacteriocinsmentioning

confidence: 99%

“…Lantibiotics are peptides that undergo extensive post-translational modifications and contain residues of lanthionine and/or methyllanthionine. In the past decade, it has become clear that this class of ribosomally synthesized and post-translationally modified peptides (RiPPs) is more diverse [ 17 ]. The third class of bacteriocins previously included large (more than 10 kDa) antibacterial proteins and bacteriolysins, as well as recently identified tailocins of Gram-positive bacteria [ 26 ].…”

Section: Classification Of Bacteriocinsmentioning

confidence: 99%

“…The identification of harveycin has become the starting point for numerous studies focused on the biochemical characterization of new bacteriocins and bacteriocin-like compounds. To date, it is known that approximately 10% of marine bacteria that form biofilms have antibacterial activity [ 17 ]. Produced bacteriocins can be small peptides (5–10 kDa), such as microcins of Gram-negative bacteria, microgalocins of halobacteria, and class I and II bacteriocins of Gram-positive bacteria, as well as larger compounds (10–90 kDa), such as colicins and colicin-like bacteriocins of Gram-negative bacteria.…”

Section: Sources Of Bacteriocinsmentioning

confidence: 99%

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Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins

et al. 2020

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This paper summarizes information about the division of bacteriocins into classes (Gram-negative bacteria, Gram-positive bacteria, and archaea). Methods for producing bacteriocins have been studied. It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. It is established that the main method of bacteriocin research is PCR analysis, which makes it possible to quickly and easily identify the presence of bacteriocin encoding genes. The mechanism of cytotoxic action of bacteriocins has been studied. It is proved that the study of cytotoxic (antitumor) activity in laboratory conditions will lead to the clinical use of bacteriocins for cancer treatment in the near future. It is established that the incorporation of bacteriocins into nanoparticles and targeted delivery to areas of infection may soon become an effective treatment method. The delivery of bacteriocins in a concentrated form, such as encapsulated in nanoparticles, will increase their effectiveness and minimize potential toxic side effects. The analysis of publications on this topic confirmed that diverse research on bacteriocins is relevant.

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“…Pyruvic acid is considered as one of the key intermediates in TCA cycle and Embden-Meyerhof-Parnas (EMP) pathways, and has important function in bacteriocin biosynthesis. Acetic acid resulted in increasing level of purines and pyrimidines which favour plasmid-encoded bacteriocin gene expression (Ge et al 2019). However, depending on the species and medium composition, the concentration of these organic acids may vary.…”

Section: Temperature and Phmentioning

confidence: 99%

Biomanufacturing process for the production of bacteriocins from Bacillaceae family

Lajis

2020

Bioresour. Bioprocess.

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Members of Bacillaceae family are of major interest in medical industry due to vast antimicrobial peptides they produce as therapeutic agents. For decades, synthetic and natural occurring antibiotics have been used to treat infectious diseases, but heavy dependence on these drugs has led to significant drawbacks which propel continuous development of new antibiotics generation. Recent findings have shown several bacteriocins of Bacillaceae as promising alternatives to the conventional drugs to combat the emergence of new drug-resistant pathogens. In this present review, Bacillaceae bacteriocins' classification such as lantibiotics and thiazole/oxazole-modified microcins as well as their biochemical characterization such as sensitivity to enzymes, temperature, pH and chemicals are described. This article enlightens on the medical application of several Bacillaceae bacteriocins emphasizing those that underwent and ongoing preclinical trials. This review also discusses the development of Bacillaceae bacteriocins production, focusing strains selection and fermentation factors such as inocula size, medium (carbon, nitrogen, minerals sources), temperature, pH, agitation and aeration rate, dissolved oxygen tension (DOT), fermentation time, inducers and mode of operation via various statistical methods for their optimization. It also highlights recent advance in the production of bioengineered and recombinant bacteriocins in bioreactors system which are rarely disclosed in literature.

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Effect of Acetic Acid on Bacteriocin Production by Gram-Positive

Cited by 32 publications

References 62 publications

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins

Biomanufacturing process for the production of bacteriocins from Bacillaceae family

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