Effect of acetaldehyde and acetylsalicylic acid on HbA1c chromatography in the FPLC method with Mono S cation exchanger

Koskinen, Leena; Korpela, Markku; Lahtela, Jorma; Laippala, Pékka; Pikkarainen, P; Koivula, Timo

doi:10.1016/s0009-8981(98)00076-x

Cited by 8 publications

(12 citation statements)

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“…A ação de drogas, como a aspirina, na formação e determinação da GHb tem sido estudada (79,82,83). A aspirina pode levar à formação de um derivado de Hb "acetilado", o qual, devido à sua carga elétrica, migra junto com a GHb naqueles métodos que baseiam-se na diferença de carga para a dosagem de GHb, resultando em valores falsamente elevados.…”

Section: Fatores Que Afetam Os Resultadosunclassified

“…Em um destes estudos (82), foi demonstrado que a ingestão de aspirina acarreta um aumento aparente de GHb. Outros dois estudos (79,83) não encontraram diferenças nos valores de GHb após ingestão de aspirina. Da mesma forma que a interferência pelas Hb anô-malas e pela uremia, a interferência da aspirina é méto-do-dependente.…”

Section: Fatores Que Afetam Os Resultadosunclassified

“…Da mesma forma que a interferência pelas Hb anô-malas e pela uremia, a interferência da aspirina é méto-do-dependente. O consumo abusivo de álcool, semelhante à aspirina, pode levar à formação do mesmo derivado "acetilado", interferindo também nas dosagens de GHb (83).…”

Section: Fatores Que Afetam Os Resultadosunclassified

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Glico-hemoglobina (HbA1c): aspectos clínicos e analíticos

Camargo

Gross

2004

Arq Bras Endocrinol Metab

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RESUMOA glico-hemoglobina (GHb) é um parâmetro importante no controle glicêmico de pacientes com DM. Vários estudos clínicos mostraram claramente que a melhora no controle glicêmico está fortemente associada com a diminuição no desenvolvimento e/ou progressão das complicações em diabetes melito tipos 1 e 2. A medida exata e precisa da GHb é uma questão importante para os laboratórios clínicos. Vários fatores afetam os resultados e podem levar a resultados errôneos. Nesta revisão, discutimos os problemas da padronização da determinação da GHb para monitorar a terapia diabética e também os principais fatores interferentes. Os métodos para GHb podem ser diferentemente afetados pelas interferências. O efeito da interferência pode ser clinicamente mais relevante com o pior controle glicêmico. O laboratório deve estar atento para estes fatores para evitar confusão na interpretação clínica dos resultados, e os clínicos devem contatar o laboratório sempre que houver discrepância entre a impressão clínica e o resultado laboratorial. Glycohemoglobin (GHb) has a key role in the assessment of glycemic control in diabetic patients. Several studies have clearly shown that improved glycemic control is strongly associated with decreased development and/or progression of diabetic complications in both type 1 and 2 diabetes mellitus. Therefore, accurate determination of GHb concentration is an important issue for clinical laboratories. Several factors may affect and lead to erroneous results. We discuss the problems of standardization of GHb measurements for monitoring glycemic control and also consider the potential interfering factors on GHb measurements. Moreover, GHb assays may be affected by interference in different ways. The effect of interference may be more clinically relevant with poor metabolic control. Laboratory staff must be aware of all pitfalls to avoid adding more confusion to the clinical interpretation of HbA 1c values and physicians should contact laboratories if discrepancies between clinical impressions and laboratory data are observed.

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Section: Fatores Que Afetam Os Resultadosunclassified

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Glico-hemoglobina (HbA1c): aspectos clínicos e analíticos

Camargo

Gross

2004

Arq Bras Endocrinol Metab

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“…Meanwhile, Koskinen et al . showed that the in vivo effects of alcohol are negligible in routine HbA1 measurement [26]. …”

Section: Discussionmentioning

confidence: 99%

“…Malnutrition, a shortened erythrocyte lifespan, and chronic liver disease even in the absence of cirrhosis and splenomegaly in heavy alcohol drinkers could contribute to decreased HbA1c levels in subjects with heavy drinkers [2,26]. …”

Section: Discussionmentioning

confidence: 99%

Association between Alcohol Intake and Hemoglobin A1c in the Korean Adults: The 2011-2013 Korea National Health and Nutrition Examination Survey

2016

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BackgroundAlthough alcohol consumption is commonly encountered in clinical practice, few studies have investigated the clinical significance of alcohol intake on the use of the hemoglobin A1c (HbA1c) level.ObjectivesThis study was performed to investigate the association between alcohol intake and HbA1c level in the general population.MethodsAmong the 24,594 participants who participated in the 2011–2013 Korea National Health and Nutrition Examination Survey (KNHANES), 12,923 participants were analyzed in this study. We excluded diabetic patients currently taking antidiabetes medication. We compared the HbA1c level and proportions of patients with an HbA1c level of ≥5.7%, ≥6.1%, and ≥6.5% according to the fasting plasma glucose (FPG) concentration range and the amount of alcohol intake. The average amounts of daily alcohol intake were categorized into three groups: 0 g/day, <30 g/day, ≥30 g/day.ResultsThe mean HbA1c level was 5.65%, and the mean FPG concentration was 95.3 mg/dl. The percentages of patients with an HbA1c level of ≥5.7%, ≥6.1%, and ≥6.5% were 42.6%, 13.4%, and 4.5%, respectively. The average amount of alcohol intake was 12.3 g/day. The percentages of subjects with alcohol intake 0, <30, and ≥ 30 g/day were 16.5%, 69.7%, and 13.8%, respectively.There was a significant positive relationship between alcohol intake and FPG concentration (P < 0.001), the prevalence of impaired fasting glucose (P < 0.001), and the prevalence of diabetes (P < 0.001). However, there was no significant relationship between the alcohol intake and HbA1c level.Overall, the adjusted HbA1c levels decreased across alcohol intake (5.70% ± 0.01%, 5.66% ± 0.01%, and 5.55% ± 0.01%) after adjustment for confounding factors such as age, sex, FPG concentration, college graduation, smoking history, presence of hypertension, waist circumference, serum total cholesterol concentration, serum high-density lipoprotein cholesterol concentration, serum triglyceride concentration, presence of anemia, serum white blood cell count, and serum alanine aminotransferase concentration (P < 0.001). The adjusted proportions (%) of patients with an HbA1c level of ≥5.7% (P < 0.001), ≥6.1% (P < 0.001), and ≥6.5% (P < 0.001) showed significant negative trends across alcohol intake after adjustment for confounders. Logistic regression analyses showed that, when using the group that abstained as the control, the group that consumed ≥ 30g/day was negatively associated with the risk of an HbA1c level of ≥5.7% (P < 0.001), ≥6.1% (P < 0.001), and ≥6.5% (P < 0.001), using the above-mentioned variables as covariates.ConclusionsHigher alcohol intake was associated with lower HbA1c levels, even after adjusting for confounding factors, including the FPG concentration, in this nationally representative sample of Korean adults. These results suggest that excessive drinking shifts the HbA1c level downward, which might complicate use of the HbA1c level for the diagnosis of diabetes or prediabetes.

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