Effect of abnormal sperm head morphology on the outcome of intracytoplasmic sperm injection in humans

Tašdemir, Išik; Taşdemir, Murat; Tavukcuoglu, Safak; Kahraman, Semra; Biberoğlu, Kutay

doi:10.1093/humrep/12.6.1214

Cited by 81 publications

(47 citation statements)

References 17 publications

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“…1,13,14,17 Tasdemir et al pointed out that morphology is the most valuable parameter in predicting the sperm-fertilizing capacity in vitro. 18 In another study, Menkveld et al revealed that cases with severe teratozoospermia had yielded a lower implantation and ongoing pregnancy rate when compared with cases of normal sperm morphology. 19 Moreover, Tasdemir and associates showed that in 17 patients with 100% teratozoospermia with abnormal sperm heads, only one ongoing pregnancy was achieved (5.88% per cycle).…”

Section: Discussionmentioning

confidence: 98%

“…19 Moreover, Tasdemir and associates showed that in 17 patients with 100% teratozoospermia with abnormal sperm heads, only one ongoing pregnancy was achieved (5.88% per cycle). 18 Although the pregnancy rate is extremely low in ICSI cases with absolute teratozoospermia with sperm head defects, ICSI still remains the only method of choice for treating severe male infertility. It is possible that abnormal sperm head morphology reflects structural abnormalities within the cell, which can directly impair the outcome of the ICSI treatment cycles.…”

Section: Discussionmentioning

confidence: 99%

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Failure of Fertilization Following Intracytoplasmic Injection of Round-Headed Sperm

et al. 1998

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Background: Intracytoplasmic sperm injection (ICSI) is a very effective technique for the treatment of male factor infertility, even in severe cases. An exception to this rule is round-headed acrosomeless sperm, for which there is an extremely low success rate. The objective of this study was to report our first experience with ICSI using roundheaded spermatozoa. Materials and Methods: A total of four infertile males with globozoospermia underwent the conventional ICSI program during the period from 1995 to 1997. Semen parameters were evaluated according to the WHO criteria. Twenty-eight oocytes were collected following conventional ovarian superovulation. Results: Volume, pH, and viscosity of the semen were within normal range. Sperm counts and progressive motility were from >1 to 90x10 6 mL, and from 0% to 60%, respectively. Distinct 100% acrosomeless morphology was observed with Giemsa staining. Twenty-two metaphase II oocytes (78.6% of the total) from four ICSI cases were injected with the husband's round-headed spermatozoa. Total fertilization failure was observed in all these cases. Conclusion:The results clearly demonstrate the important role of normal head morphology in activating the oocytes, as well as the need to develop a modified but safe ICSI technique, which will be effective in overcoming this severe type of male infertility.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Failure of Fertilization Following Intracytoplasmic Injection of Round-Headed Sperm

et al. 1998

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“…Several studies have demonstrated that sperm morphology seems to be the best predictor of outcome in spontaneous pregnancy [2,3], intra-uterine insemination (IUI) [1,7] and conventional IVF [21]. Other papers considered sperm morphology as a prognostic factor of male fertility [12,21,28,29].…”

Section: Introductionmentioning

confidence: 99%

Sperm head vacuolization affects clinical outcome in ICSI cycle. A proposal of a cut-off value

Falagario

Brucculeri

Depalo

et al. 2012

J Assist Reprod Genet

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Objective To evaluate the relationship between sperm nuclear vacuoles and sperm morphology and to investigate the influence of the rate of spermatozoa with head vacuolization (SVR) in a seminal sample on the clinical outcomes in couples undergoing intracytoplasmic sperm injection. Materials 26 patients undergoing infertility investigations were included and were divided in two groups according to an SVR≤20,28 % (Group A) or>20,28 % (Group B), and were investigated to verify the influence of SVR on the fertilization rate, embryo quality, pregnancy and implantation rates. Results Abnormal spermatozoa with nuclear vacuoles were significantly higher (p<0.001) than the percentage of normal spermatozoa with nuclear vacuoles. Patients in group A had a percentage of abnormal sperm with nuclear vacuole significantly lower compared to group B (p<0,001), but there was no difference in the percentage of normal sperm with nuclear vacuoles. Fertilization rates and the number of top quality embryos did not differ between the two groups. The pregnancy and implantation rates were significantly higher in Group A compared to Group B (respectively p<0,05 and p<0.001). Conclusions For the first time, we propose a cut off value in the proportion of sperms with nuclear vacuolization on the total of sperm in seminal samples, and demonstrate a relationship between SNV and clinical outcomes after ICSI. The SNV rate could be introduced as an easy diagnostic evaluation prior to perform an ICSI cycle.

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“…The induction of the sperm head abnormality can be either due to impaired spermatogenesis or damage in the genetic material of spermatogonia and spermatocytes. Tasdemir et al (1997) reported that abnormality in the sperm head morphology reflects abnormality in spermatogenesis. Wyrobek et al (1983) also noted that when male germ cells are exposed in vivo to a test sample, a positive result demonstrates the sample ability to damage spermatogenesis.…”

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confidence: 99%

Cytogenotoxic Effects and Reproductive Abnormalities Induced by e-Waste Contaminated Underground Water in Mice

Alabi

Bakare

2014

CYTOLOGIA

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Summary Indiscriminate disposal of electronic wastes (e-wastes) in Nigeria is on the increase. The release of hazardous substances from these wastes may have harmful consequences on the environment and public health. This study was designed to investigate the potential in vivo genetic and reproductive toxicity of e-waste contaminated underground (well) waters obtained from Alaba International and Computer Village electronic markets in Lagos, Nigeria, using the murine micronucleus (MN), sperm morphology and sperm count assays. The animals were exposed orally via free drinking of the water for one to five weeks. MN analysis showed a concentration-dependent induction of micronucleated polychromatic erythrocytes across the treatment groups. Assessment of sperm shape showed a significant increase in sperm abnormalities with significant decrease in mean sperm count in treated groups. The presence of Pb, Cu, Cr, and Cd in the tested samples is believed to contribute significantly to these observations. The results are indications that e-waste contaminated well water is capable of inducing somatic and germ mutation in living cells, and should be of public health concern in countries with risk of e-waste exposure.

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Effect of abnormal sperm head morphology on the outcome of intracytoplasmic sperm injection in humans

Cited by 81 publications

References 17 publications

Failure of Fertilization Following Intracytoplasmic Injection of Round-Headed Sperm

Failure of Fertilization Following Intracytoplasmic Injection of Round-Headed Sperm

Sperm head vacuolization affects clinical outcome in ICSI cycle. A proposal of a cut-off value

Cytogenotoxic Effects and Reproductive Abnormalities Induced by e-Waste Contaminated Underground Water in Mice

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