Effect of a synthetic gastrin-like pentapeptide upon the intestinal transport of sodium, potassium, and water.

Hormones and Water Movement Through the Vertebrate Intestine

“…G ardener and his colleagues [46] using crude hog gastrin and everted hamster sacs found that there was inhibition of salt and fluid transfer in the distal small intestine but not in the proximal or medial small intestine. Similar results have been obtained using synthetic pentagastrin [50], reduction of sodium and water absorption occurring in the jejunum and ileum but not in the colon.…”

The Method of Intraluminal Perfusion of the Human Small Intestine

“…Furthermore, pentagastrin simultaneously reduced jejunal insorption and exsorption of water and ions, whether the sugar was present or not, the reduction of insorption being greater when glucose was present [58]. No effect of the pentapeptidc was found in the human ileum [58] contrary to what has been reported in animals [33,36], Cholecystokinin [52] increases the net secretion of water and electrolytes into the jejunal lumen by decreasing insorption. This effect is interpreted as probably secondary to the acceleration of intestinal transit induced by the hormone.…”

Effect of Tetragastrin on Calcium Absorption from Rat Duodenal Loop <I>in vivo</I>

“…Effect of gastrin on intestinal absorption has not been studied extensively. The effect of gastrin on intestinal transport of ions and water was denied (Hubel 1972) and water absorption was reported to be inhibited by gastrin (Gingell et al 1968, Bynum et al 1971.…”