Effect of a Sugar-Free Chewing Gum Containing Magnolia Bark Extract on Different Variables Related to Caries and Gingivitis: A Randomized Controlled Intervention Trial

Abstract

The effect of magnolia bark extract (MBE) on different variables related to caries and gingivitis administered daily through a sugar-free chewing gum was evaluated. The study was performed with healthy adult volunteers at high risk for caries as a randomized double-blind interventional study. 120 subjects with a salivary mutans streptococci (MS) concentration ≧10⁵ CFU/ml and presence of bleeding on probing >25% were enrolled and divided into three groups: magnolia, xylitol and control. The study design included examinations at baseline, after 7 days, after 30 days of gum use and 7 days after the end of gum use. Plaque pH was assessed using the strip method following a sucrose challenge. Area under the curve (AUC_5.7 and AUC_6.2) was recorded. Whole saliva was collected and the number of salivary MS (CFU/ml) was counted. Bleeding on probing was recorded as a proxy of dental plaque. Data were analyzed using ANOVA repeated measures. Magnolia gum significantly reduced plaque acidogenicity, MS salivary concentration and gingival bleeding compared to xylitol and control gums. Subjects from the magnolia and xylitol groups showed both MS concentration (p = 0.01 and 0.06, respectively) and AUC_5.7 (p = 0.01 and 0.04, respectively) to be significantly lower compared to baseline. Thirty-day use of a chewing gum containing MBE showed beneficial effects on oral health, including reduction of salivary MS, plaque acidogenicity and bleeding on probing.

An in vitro and in vivo Comparison of the Effect of <b><i>Stevia rebaudiana</i></b> Extracts on Different Caries-Related Variables: A Randomized Controlled Trial Pilot Study

“…The use of plant extracts is becoming quite popular in caries prevention strategies [Kim and Kinghorn, 2002;Campus et al, 2011]. The present study was aimed to evaluate the effect of the 2 extracts from S. rebaudiana , stevioside and rebaudioside A, on in vitro S. mutans biofilm growth and on plaque pH in vivo.…”

Chewing Xylitol Gum Improves Self-Rated and Objective Indicators of Oral Health Status under Conditions Interrupting Regular Oral Hygiene

“…A randomized controlled intervention trial (Campus et al 2011) revealed that healthy adult individuals who chewed xylitol gum had a significantly lower concentration of salivary Streptococcus mutans compared to baseline. A systematic review of the literature suggested that the use of xylitol chewing gum as an adjunct to tooth brushing provided a beneficial reduction in plaque scores in a systematic review (Keukenmeester et al 2013).…”

Extracts of Magnolia Species-Induced Prevention of Diabetic Complications: A Brief Review

“…Mechanisms of antidiabetes are still unclear for Magnolia constituents. Therefore, ME are not used in antidiabetic clinical trial, though, clinical trials have demonstrated that ME may be important medicines for treating a variety of conditions such as menopause [53], anxiety [54], and gingivitis [55]. Now, it is necessary that we identify the bioactive constituents of ME, and delineate possible mechanisms.…”