Effect of a soluble pseudo-receptor on verotoxin 2-induced toxicity

Verotoxin Receptor-Based Pathology and Therapies

“…Despite protection against VT in cell culture, subsequent in vivo mouse susceptibility studies with adabisGb 3 showed that treated mice showed a more rapid VT-induced pathology than control mice. A similar effect has been reported for lysoGb 3 containing liposomes in vivo (Takenaga et al, 2000). While the basis of this effect in not clear, it may relate to the potential of multivalent VT to show cooperative receptor binding (Peter and Lingwood, 2000).…”

Quantification of the Fabry marker lysoGb3 in human plasma by tandem mass spectrometry

“…In addition, they discussed whether lysoGb3 may play a role in disease progression, but molecular mechanisms or clinical consequences are currently unclear. LysoGb3 enhances toxicity of the viper venom verotoxin 2, a protein which binds to the natural membrane-anchored Gb3 receptor [24], and Gb3 levels in fibroblasts were increased upon addition of lysoGb3 [23]. This indicates that lysoGb3 may inhibit the key enzyme ␣-galactosidase, but this could not be confirmed up to now [25].…”