Effect of a Six Week-Swimming Interval Training with Resveratrol Consumption on Apoptotic Markers in the Liver Tissue of Aged Rat

Mehboudi, Maryam; Asgharpour, Habib; Hosseini, Seyed Ali; Rezaeeshirazi, Reza

doi:10.18502/ehj.v7i1.6550

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been recommended to use antioxidants such as resveratrol for the treatment of many diseases due to its antioxidant, anti-inflammatory, anti-apoptotic properties, which can enhance the metabolism of fats and glucose [11]. Since there is scant research on the combined effects of training and resveratrol use on expression of antioxidant genes, the present study aims to examine the combined effects of high-intensity intermittent swimming and resveratrol use on antioxidant markers and lipid peroxidation index in the liver tissue of older rats.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Swimming and Resveratrol on Antioxidant Markers and Lipid Peroxidation Index in Liver Tissue

Mehboodi

Asgharpour²,

Hosseini³

et al. 2023

JGUMS

View full text Add to dashboard Cite

Background Aging is associated with metabolic disorders. Although the beneficial effects of exercise and resveratrol consumption in the health of the elderly has been reported, the combined effect of intermittent swimming and resveratrol consumption on the antioxidant system in liver tissue is not clear yet. Objective This study aims to investigate the combined effect of intermittent swimming and resveratrol consumption on the expression of superoxide dismutases (SOD), glutathione peroxidase (GPx), and Malondialdehyde (MDA) in the liver tissue of older rats. Methods In this experimental study, 32 elder rats were divided into four groups: control, swimming, resveratrol and swimming+resveratrol. The resveratrol (100 mg) dissolved in 1% methylcellulose was administrated daily by gavage. The swimming was performed at three sessions per week. The GPx and SOD expression levels were measured by real-time polymerase chain reaction method, and the MDA level was measured by ELISA method. Results The GPx level in the swimming+resveratrol group were significantly higher than in the control (P=0.001), resveratrol (P=0.04) and swimming (P=0.002) groups. MDA levels in the resveratrol (P=0.001), swimming (P=0.001) and swimming+resveratrol (P=0.001) groups were significantly lower than in the control group; in the swimming+resveratrol group, it was significantly lower than the resveratrol (P=0.001) and swimming (P=0.009) groups. Conclusion It seems that intermittent swimming and resveratrol consumption have favorable effects on improving the antioxidant defense system and lipid peroxidation in liver tissue. Therefore, it is recommended to use intermittent swimming and resveratrol to prevent liver damage in the elderly.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effect of Swimming and Resveratrol on Antioxidant Markers and Lipid Peroxidation Index in Liver Tissue

Mehboodi

Asgharpour²,

Hosseini³

et al. 2023

JGUMS

View full text Add to dashboard Cite

show abstract

Comparison of the Effect of 8- and 12-Week Aerobic Exercise with Calorie Restriction on the Bax and Bcl-2 Expression in Rats with Non-alcoholic Fatty Liver Disease

Mirzaei,

Rahmaninia,

Mohebbi

et al. 2023

Ann Mil Health Sci Res

View full text Add to dashboard Cite

Background: In addition to oxidative stress, the apoptosis of liver cells plays a main role in non-alcoholic steatohepatitis pathogenesis. Nevertheless, the main mechanisms of the response of liver cell apoptosis in non-alcoholic steatohepatitis (NASH) models caused by a high-fat diet, as well as the effects of exercise with and without calorie restriction on these mechanisms, have not been assessed to date. Objectives: The present study aimed to investigate the effects of two exercise protocols with and without calorie restriction on apoptosis and liver damage in rats with non-alcoholic fatty liver disease (NAFLD). Methods: Sixty-four male Wistar rats were subjected to a high-fat diet for eight weeks and were divided randomly into eight groups: Control, calorie restriction (CR), aerobic exercise (AE), and aerobic exercise + calorie restriction (AC) for eight and twelve weeks. Also, two groups of rats that had normal and free access to food were named sham groups. The training groups exercised on the treadmill for five sessions a week for eight and twelve weeks. Two-way ANOVA was utilized for data analysis at a significance level of 0.05. Results: According to the findings, in both 8- and 12-week protocols, the expression of Bax proteins in the exercise and exercise + calorie restriction groups showed a significant decrease compared to the control group (P < 0.05). Also, Bcl-2 protein expression significantly increased in the exercise and exercise + calorie restriction groups than the control group (P < 0.05). The training groups showed no significant difference between the 8- and 12-week protocols. Conclusions: It was revealed that exercise with and without caloric restriction and independent of the protocol duration can improve the apoptosis of hepatocytes in NAFLD.

show abstract

Effect of a Six Week-Swimming Interval Training with Resveratrol Consumption on Apoptotic Markers in the Liver Tissue of Aged Rat

Cited by 2 publications

References 0 publications

The Effect of Swimming and Resveratrol on Antioxidant Markers and Lipid Peroxidation Index in Liver Tissue

The Effect of Swimming and Resveratrol on Antioxidant Markers and Lipid Peroxidation Index in Liver Tissue

Comparison of the Effect of 8- and 12-Week Aerobic Exercise with Calorie Restriction on the Bax and Bcl-2 Expression in Rats with Non-alcoholic Fatty Liver Disease

Contact Info

Product

Resources

About