Effect of a single dose of pamidronate administered at the time of surgery in a rabbit posterolateral spinal fusion model

Urrutia, Julio; Briceño, Jorge; Carmona, Maximiliano; Olavarría, Fernando; Hodgson, Felipe

doi:10.1007/s00586-010-1288-y

Cited by 6 publications

(5 citation statements)

References 38 publications

(40 reference statements)

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“…The aim of this study was to achieve a fusion rate of less than 40 % and then determine whether autologous bone marrow augmented arthrodesis. Other studies subsequently used this bone paucity model to provide a larger potential for improved fusion rates with a variety of bone graft substitutes [13][14][15][16][17][18][19][20][21][22]. While our study found a significant positive relationship between volume of autograft and fusion rates, a tenfold range of volume of autograft (1.4-12 cm 3 ) was used in the studies evaluated.…”

Section: Discussionmentioning

confidence: 79%

Factors influencing arthrodesis rates in a rabbit posterolateral spine model with iliac crest autograft

et al. 2013

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Purpose The rabbit posterolateral intertransverse spine arthrodesis model has been widely used to evaluate spinal biologics. However, to date, the validity and reproducibility of performance of iliac crest bone graft, the most common and critical control group, has not been firmly established. We evaluated original research publications that utilized this model, identified which experimental conditions affected fusion rates, and developed an algorithm to predict fusion rates for future study designs. Methods A MEDLINE search was performed for publications through December, 2011 that utilized this model to evaluate fusion rates elicited by iliac crest autograft. All study parameters were recorded, and logistic regression analyses were performed to determine the effects of these variables on fusion rates as determined by either manual palpation or radiographs. Results Seventy studies with 959 rabbits in 102 groups met the inclusion criteria. Excluding studies that measured fusion at 4 or fewer weeks or intentionally tried to decrease the fusion rate, the overall fusion rate for autograft was 58.3 ± 16.3 % (mean ± SD) as determined by manual palpation and 66.4 ± 17.8 % by plain radiographs. Regression analysis demonstrated a difference between these outcome measures with a trend towards significance (p = 0.09). Longer time points and larger volumes of autograft resulted in significantly greater reported fusion rates (p \ 0.0001 and p \ 0.05, respectively). Neither strain, age, weight, nor vertebral level significantly affected fusion rates. Conclusions Although experimental conditions varied across studies, time point evaluation and autograft volume significantly affected fusion rates. Despite some variability demonstrated across certain studies, we demonstrated that when the time point and volume of autograft were controlled for, the iliac crest control group of the rabbit posterolateral spinal arthrodesis model is both reliable and predictably affected by different experimental conditions.

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Section: Discussionmentioning

confidence: 79%

Factors influencing arthrodesis rates in a rabbit posterolateral spine model with iliac crest autograft

et al. 2013

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“…For this reason, longer instrumented fusions that span the entire thoracic spine are often needed. The role of bisphosphonates in spinal fusion is controversial in the literature with some reports suggesting inhibition of fusion, while others state the opposite [34][35][36][37][38][39][40][41][42][43][44][45][46]. In contrast, both animal and clinical studies seem to suggest that teriparatide [recombinant human parathyroid hormone (rhPTH)] enhances fusion [47][48][49][50].…”

Section: Suggestions To Minimize Pjkmentioning

confidence: 88%

Proximal junctional kyphosis following adult spinal deformity surgery

2014

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“…This dose in rats is equivalent to 250 mg in a 70 kg human [25]. The pamidronate infusion dose was based on previous studies with small animals, which demonstrated the pharmacological effect of the drug [26,27], and is equivalent to 35 mg in a 70 kg human [25].…”

Section: Methodsmentioning

confidence: 99%

Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats

Carvalho

Gonçalves

Alegre

et al. 2016

Cell Physiol Biochem

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Background: Cardiotoxicity is the major side effect of doxorubicin. As mechanisms that are involved in cardiotoxicity are ambiguous, new methods for attenuating cardiotoxicity are needed. Recent studies have shown that bisphosphonates can decrease oxidative stress. Therefore, the objective of this study was to evaluate the effect of pamidronate on preventing acute doxorubicin-induced cardiotoxicity. Methods: Sixty-four male Wistar rats were allocated into four groups: the control group (C), the pamidronate group (P), the doxorubicin group (D) and the doxorubicin/pamidronate group (DP). The rats in the P and DP groups received pamidronate injections (3 mg/kg, IP). After 24 hours, the rats in the D and DP groups received doxorubicin injections (20 mg/kg, IP). Forty-eight hours after doxorubicin injection, the rats were killed. Echocardiography, isolated heart study and biochemical analysis were performed. Results: Doxorubicin-induced acute cardiotoxicity showed increased matrix metalloproteinases (MMP)-2 activation, oxidative damage and induced alterations in myocardial energetic metabolism. Pamidronate did not inhibit MMP-2 activation but attenuated oxidative stress and improved myocardial energetic metabolism. Regarding cardiac function, the DP group exhibited a decrease in the left ventricular ejection fraction in the echocardiography and a decrease in +dP/dt in the isolated heart study compared with other groups. The same DP group presented serum hypocalcaemia. Conclusions: Despite its ability to reduce oxidative stress and improve energy metabolism in the heart, pamidronate worsened systolic function in rats treated with doxorubicin, and therefore we cannot recommend its use in conjunction with anthracycline chemotherapy.

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Effect of a single dose of pamidronate administered at the time of surgery in a rabbit posterolateral spinal fusion model

Cited by 6 publications

References 38 publications

Factors influencing arthrodesis rates in a rabbit posterolateral spine model with iliac crest autograft

Factors influencing arthrodesis rates in a rabbit posterolateral spine model with iliac crest autograft

Proximal junctional kyphosis following adult spinal deformity surgery

Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats

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