Effect of a Prolonged Altitude Expedition on Glucose Tolerance and Abdominal Fatness

Chen, Mu-Tsung; Lee, Wen‐Chih; Chen, Shih-Chang; Chen, Chiu-Chou; Lee, Shin-Da; Jensen, Jørgen; Kuo, Chia‐Hua

doi:10.1080/02701367.2010.10599708

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…Manipulating food intake resulted in a weight change of between -1.0 and -0.6 kg, or up to -1.8 kg when combined with heavy military exercise (ET: 5 to 21 days) (Greenleaf et al, 1978; Schena et al, 1992; Hoyt et al, 1994). One study found no reduction in body weight (Chen et al, 2010; Chia et al, 2013). Reductions in FFM were reported to range from -3.1 to -0.2 kg whereas increases in FFM ranged from 0.7 to 1.6 kg (Schena et al, 1992; Gunga et al, 2003; Chia et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis

et al. 2019

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Changes in body composition and weight loss frequently occur when humans are exposed to hypoxic environments. The mechanisms thought to be responsible for these changes are increased energy expenditure resulting from increased basal metabolic rate and/or high levels of physical activity, inadequate energy intake, fluid loss as well as gastrointestinal malabsorption. The severity of hypoxia, the duration of exposure as well as the level of physical activity also seem to play crucial roles in the final outcome. On one hand, excessive weight loss in mountaineers exercising at high altitudes may affect performance and climbing success. On the other, hypoxic conditioning is presumed to have an important therapeutic potential in weight management programs in overweight/obese people, especially in combination with exercise. In this regard, it is important to define the hypoxia effect on both body composition and weight change. The purpose of this study is to define, through the use of meta-analysis, the extent of bodyweight -and body composition changes within the three internationally classified altitude levels (moderate altitude: 1500–3500 m; high altitude: 3500–5300 m; extreme altitude: >5300 m), with emphasis on physical activity, nutrition, duration of stay and type of exposure.

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Section: Resultsmentioning

confidence: 99%

Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis

et al. 2019

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“…One way to avoid this shortcoming would be to train an individual under normoxic condition but to recover under an extended period of moderate hypoxia. Such training method is effective to improve the whole-body glucose tolerance for lean individuals (Chen et al, 2010). Yet, it is unknown whether such a training method produces greater metabolic benefits for genetically obese animals than exercise training alone.…”

Section: Discussionmentioning

confidence: 99%

Hyperinsulinemia and overweight in obese Zucker rats effectively suppressed by exercise training with hypoxia recovery

Tsai

Huang

et al. 2011

European Journal of Sport Science

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It is currently unknown whether hypoxia training can effectively suppress overweight and hyperinsulinemia in genetically obese animals. In this study, both lean and obese Zucker rats were randomly assigned into the following groups: control (CON, n 07), exercise training (EX, n 07), hypoxia (HYP, n 07) and exercise training with hypoxia recovery (EX ' HYP, n 07). During a 6-week training period, rats performed swimming exercise progressively from 30 to 180 min ×day (1 , and recovered under hypoxia (14% oxygen for 8 h×day (1 ). Obese Zucker rats exhibited substantially greater fasting insulin levels, and exaggerated glucose and insulin responses following an oral glucose challenge compared with lean rats. At the beginning of week 6, body weight, fasting glucose, fasting insulin, area under curve of glucose (GAUC) and insulin (IAUC) in the EX ' HYP group were significantly lower than CON group among the obese rats. Meanwhile, only GAUC was significantly lower in the EX group compared to the CON group. At the end of week 6, capillaries to fibre ratio (C/F), capillary density (CD) and type IIa fibre proportion of the plantaris muscle in the EX group were significantly greater than the CON group (P B0.05), but no additive effect of hypoxia on exercise training was observed. Our data demonstrate that exercise training with prolonged hypoxia recovery offers better metabolic benefits than exercise training alone for the obese Zucker rats. This advantage was closely associated with effective weight reduction.

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“…Moreover, insulin-mediated glucose uptake is inversely correlated with body fat mass [26][27] . In a previous study, hypoxic exposure (altitude 2,200-4,000 m) combined with aerobic exercise decreased body weight and fat mass [28][29][30] . Therefore, it could be used as a therapy for obesity with glucose control disorders.…”

Section: Effects Of Hypoxic Exposure On Glycemic Controlmentioning

confidence: 99%

Hypoxic exposure can improve blood glycemic control in high-fat diet-induced obese mice

Park

Jang

Park

et al. 2020

JENB

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Blood glucose and insulin resistance were lower following hypoxic exposure in previous studies. However, the effect of hypoxia as therapy in obese model has not been unknown. [Methods] Six-week-old mice were randomly divided into chow diet (n=10) and high-fat diet (HFD) groups (n=20). The chow diet group received a non-purified commercial diet (65 % carbohydrate, 21 % protein, and 14 % fat) and water ad libitum. The HFD group was fed an HFD (Research Diet, #D12492; 60% kcal from fat, 5.24 kcal/g). Both groups consumed their respective diet for 7 weeks. Subsequently, HFD-induced mice (12-weeks-old) were randomly divided into two treatment groups : HFD-Normoxia (HFD; n=10) and HFD-Hypoxia (HYP; n=10, fraction of inspired=14.6%). After treatment for 4 weeks, serum glucose, insulin and oral glucose tolerance tests (OGTT) were performed. [Results] Homeostatic model assessment values for insulin resistance (HOMA-IR) of the HYP group tended to be lower than the HFD group. Regarding the OGTT, the area under the curve was 13% lower for the HYP group than the HFD group. [Conclusion] Insulin resistance tended to be lower and glucose uptake capacity was significantly augmented under hypoxia. From a clinical perspective, exposure to hypoxia may be a practical method of treating obesity.

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Effect of a Prolonged Altitude Expedition on Glucose Tolerance and Abdominal Fatness

Cited by 11 publications

References 31 publications

Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis

Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis

Hyperinsulinemia and overweight in obese Zucker rats effectively suppressed by exercise training with hypoxia recovery

Hypoxic exposure can improve blood glycemic control in high-fat diet-induced obese mice

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