Effect of a Multimodal Lifestyle Intervention on Sleep and Cognitive Function in Older Adults with Probable Mild Cognitive Impairment and Poor Sleep: A Randomized Clinical Trial

Falck, Ryan S.; Davis, Jennifer C.; Best, John R.; Chan, Pak Hei; Li, Linda; Wyrough, Anne B; Bennett, Kimberly; Backhouse, Daniel; Liu‐Ambrose, Teresa

doi:10.3233/jad-200383

Cited by 37 publications

(55 citation statements)

References 62 publications

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“…A intervenção multimodal de estilo de vida, que associa terapia com luz brilhante, atividade física e higiene do sono, em comparação a higiene do sono isolada, apresentou melhores resultados relativos aos parâmetros subjetivos de qualidade do sono, na comparação à higiene do sono isolada (RR: -1,39; IC: 95% (-2,72 a -0,06), embora não tenha apresentado diferenças significativas quando avaliados parâmetros objetivos relativos à duração, fragmentação e latência do sono. Quando a higiene do sono foi associada à terapia com música, os idosos apresentaram melhoras contínuas no escore global de qualidade do sono, bem como nos parâmetros isolados avaliados pelo escore, como latência do sono, eficiência do sono e disfunção durante o dia, enquanto o grupo submetido à higiene do sono isolada apresentou melhora apenas do escore global (FALCK et al, 2020;WANG et al, 2016).…”

Section: Resultsunclassified

Práticas de higiene do sono em idosos: Uma revisão sistemática / Sleep hygiene practices in the elderly: A systematic review

Leite¹,

Santos²

2022

Braz. J. Hea. Rev.

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A população mundial de idosos vem crescendo rapidamente, com a população de maiores de 80 anos devendo triplicar de 143 milhões em 2019 para 426 milhões em 2050. Com esse crescimento aumentam as demandas de saúde relacionadas a essa faixa etária devido a doenças crônicas não transmissíveis, além de distúrbios relacionados ao sono que são comuns nesse grupo, alcançando uma prevalência de 30 a 48%. Esses transtornos são condições subjetivas de insatisfação relacionada ao início e manutenção do sono e despertar precoce, que prejudicam a qualidade de vida e acarretam aumento de risco de várias doenças, representando um preditor significativo para o início de depressão, ansiedade, abuso de álcool e psicose

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Section: Resultsunclassified

Práticas de higiene do sono em idosos: Uma revisão sistemática / Sleep hygiene practices in the elderly: A systematic review

Leite¹,

Santos²

2022

Braz. J. Hea. Rev.

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“…Lifestyle modification was explored only in the context of psychotherapeutic approaches rather than in isolation. It was with regret that a high quality randomised controlled trial in individuals from a general community setting with reduced MoCA scores, testing the effects of a multimodal tailored lifestyle intervention in improving actigraphic and subjective measures of sleep (Falck et al., 2020 ) could not be included due to our pre‐determined strict methodology regarding diagnostic criteria. The intervention consisted of sleep hygiene measures followed by the formulation of an individually timed Bright Light Therapy and was shown to have improved measures of subjective but not objective sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological and non‐pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review

Blackman

Swirski

Clynes

et al. 2020

Journal of Sleep Research

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Suboptimal sleep causes cognitive decline and probably accelerates Alzheimer's Disease (AD) progression. Several sleep interventions have been tested in established AD dementia cases. However early intervention is needed in the course of AD at Mild Cognitive Impairment (MCI) or mild dementia stages to help prevent decline and maintain good quality of life. This systematic review aims to summarize evidence on sleep interventions in MCI and mild AD dementia. Seven databases were systematically searched for interventional studies where ≥ 75% of participants met diagnostic criteria for MCI/mild AD dementia, with a control group and validated sleep outcome measures. Studies with a majority of participants diagnosed with Moderate to Severe AD were excluded. After removal of duplicates, 22,133 references were returned in two separate searches (August 2019 and September 2020). 325 full papers were reviewed with 18 retained. Included papers reported 16 separate studies, total sample (n = 1,056), mean age 73.5 years. 13 interventions were represented: Cognitive Behavioural Therapy – Insomnia (CBT‐I), A Multi‐Component Group Based Therapy, A Structured Limbs Exercise Programme, Aromatherapy, Phase Locked Loop Acoustic Stimulation, Transcranial Stimulation, Suvorexant, Melatonin, Donepezil, Galantamine, Rivastigmine, Tetrahydroaminoacridine and Continuous Positive Airway Pressure (CPAP). Psychotherapeutic approaches utilising adapted CBT‐I and a Structured Limbs Exercise Programme each achieved statistically significant improvements in the Pittsburgh Sleep Quality Index with one study reporting co‐existent improved actigraphy variables. Suvorexant significantly increased Total Sleep Time and Sleep Efficiency whilst reducing Wake After Sleep Onset time. Transcranial Stimulation enhanced cortical slow oscillations and spindle power during daytime naps. Melatonin significantly reduced sleep latency in two small studies and sleep to wakefulness transitions in a small sample. CPAP demonstrated efficacy in participants with Obstructive Sleep Apnoea. Evidence to support other interventions was limited. Whilst new evidence is emerging, there remains a paucity of evidence for sleep interventions in MCI and mild AD highlighting a pressing need for high quality experimental studies exploring alternative sleep interventions.

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“…Not only did the program improve sleep, but also cognitive function (U = 3.25, p = .001). In another randomized control trial involving sleep hygiene education, physical activity, and bright light therapy (Falck et al, 2020), older individuals in the intervention group reported a significantly better subjective sleep quality (measured using PSQI) compared to those in the control group. However, objective sleep measures (sleep efficiency, duration, fragmentation, WASO, and sleep latency) were not significantly different between the two groups.…”

Section: Interventions To Improve Sleepmentioning

confidence: 99%

Sleep, Mild Cognitive Impairment, and Interventions for Sleep Improvement: An Integrative Review

2021

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Sleep disturbance in mild cognitive impairment (MCI) is associated with progression to Alzheimer’s disease (AD), more severe AD symptoms, and worse health outcomes. The aim of this review was to examine the relationship between sleep and MCI, and the effectiveness of sleep improvement interventions for older adults with MCI or AD. An integrative review was conducted using four databases, and findings were analyzed using an iterative process. Findings from 24 studies showed that alterations in sleep increased the risk of MCI and that the sleep quality of individuals with MCI or AD was poorer than healthy controls. Changes in brain anatomy were also observed in healthy older adults with sleep disturbances. Examined interventions were shown to be effective in improving sleep. Screening for sleep disturbances in individuals with MCI/AD is crucial to mitigate neurodegenerative or neurobehavioral risks in this population.

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Effect of a Multimodal Lifestyle Intervention on Sleep and Cognitive Function in Older Adults with Probable Mild Cognitive Impairment and Poor Sleep: A Randomized Clinical Trial

Cited by 37 publications

References 62 publications

Práticas de higiene do sono em idosos: Uma revisão sistemática / Sleep hygiene practices in the elderly: A systematic review

Práticas de higiene do sono em idosos: Uma revisão sistemática / Sleep hygiene practices in the elderly: A systematic review

Pharmacological and non‐pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review

Sleep, Mild Cognitive Impairment, and Interventions for Sleep Improvement: An Integrative Review

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