Effect of a Low-Fat Diet on Bile Salt Excretion and Diarrhoea in the Gastrointestinal Radiation Syndrome

Bosæus, Ingvar; Andersson, H; Nyström, Curt

doi:10.3109/02841867909128231

Cited by 34 publications

(42 citation statements)

References 11 publications

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“…A significant reduction in bile salt malabsorption using a 40 g fat À1 day À1 diet in nine patients was reported (Bosaeus et al, 1979). The other study (Danielsson et al, 1991) observed only a moderate improvement in symptoms with the use of a bile acid sequestrant in addition to a low-fat diet.…”

Section: Complementary Nutritionmentioning

confidence: 93%

“…Elemental diet (uncontrolled) (Beer et al, 1985). Low-fat diet (uncontrolled) or low fat with bile acid sequestrant (Bosaeus et al, 1979;Danielsson et al, 1991). Gluten and cow's milk protein free with additional lactose and reduced fat/residue (Donaldson et al, 1975).…”

Section: Complementary Nutritionmentioning

confidence: 99%

“…Low-fat dietary regimens were used in two studies (Bosaeus et al, 1979;Danielsson et al, 1991), which included 187 patients. A significant reduction in bile salt malabsorption using a 40 g fat À1 day À1 diet in nine patients was reported (Bosaeus et al, 1979).…”

Section: Complementary Nutritionmentioning

confidence: 99%

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Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy

et al. 2004

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Up to 12 000 patients with gynaecological, urological and rectal cancer undergo radical pelvic radiotherapy annually in the UK. More than 70% develop acute inflammatory changes causing gastrointestinal symptoms during treatment because healthy bowel tissue is encompassed in the radiation field. In total, 50% go on to develop chronic bowel symptoms, which affect quality of life due to permanent changes in the small and large intestine. Nutritional intervention may influence acute and chronic bowel symptoms but the validity of the advice given to patients is not clear. To assess the incidence and significance of malnutrition and to examine the efficacy of therapeutic nutritional interventions used to manage gastrointestinal side effects in patients undergoing pelvic radiotherapy and those with chronic bowel side effects after treatment, a critical review of relevant original studies on human subjects was carried out using a specific set of mesh terms in MEDLINE and EMBASE databases and the Cochrane Library in September 2003. Full texts of all relevant articles were collected and reference lists were checked. Sources of grey literature including conference abstracts and webbased information were also reviewed. A total of 36 papers published in peer-reviewed journals between 1966 and 2003 were identified. In all, 14 randomised controlled trials, 12 prospective cohorts, four retrospective, two qualitative, one validation, one pilot study and two case reports were obtained. These included 2646 patients. Eight articles including three conference abstracts and webbased information were found. None of the studies was definitive because of weakness in methodology. No studies could be combined because the interventions and the end points were different. There is no evidence base for the use of nutritional interventions to prevent or manage bowel symptoms attributable to radiotherapy. Low-fat diets, probiotic supplementation and elemental diet merit further investigation.

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Section: Complementary Nutritionmentioning

confidence: 93%

Section: Complementary Nutritionmentioning

confidence: 99%

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Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy

et al. 2004

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“…Clinically, the use of elemental diets (58,(70)(71)(72), low-fat diets (73)(74)(75), manipulation of bacterial flora (76), anti-inflammatory drugs (77,78), bile acid sequestering resins (79), or enteroprotective drugs (80) during the course of radiation therapy appear to ameliorate symptoms of acute intestinal injury, and possibly also the severity of damage. Other prophylactic measures include surgical exclusion of the small bowel from the pelvis prior to irradiation for pelvic neoplasms by the use of polyglycolic acid mesh (81-84) omentum (85-87), bladder (88), or various types of 'spacers' (89)(90)(91).…”

Section: Late Radiation Enteropathymentioning

confidence: 99%

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Hauer‐Jensen

1990

Acta Oncologica

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“…However, a review of the literature on diarrhea in adults suggests that the methods for measuring diarrhea are varied and there is no "gold standard" (Belknap, Davidson, & Smith, 1997;Bosaeus, Anderson, Nystrom, 1979;Bounous, Lebel, Shuster, Gold, Tahan, & Baslin, 1975;Capirci et al, 1993;NCIC-CTG, 1991;Rutledge & Engelking, 1998;Smalley, Klish, Campbell, & Brown, 1982). Parameters that have been reported include frequency, texture, blood in stools, incontinence, patient selfreporting, use of medications, and stopping radiotherapy treatments.…”

Section: Literature Reviewmentioning

confidence: 99%

Testing control of radiationinduced diarrhea with a psyllium bulking agent: A pilot study

Murphy¹,

Stacey²,

Crook³

et al. 2000

CONJ

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Effect of a Low-Fat Diet on Bile Salt Excretion and Diarrhoea in the Gastrointestinal Radiation Syndrome

Cited by 34 publications

References 11 publications

Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy

Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Testing control of radiationinduced diarrhea with a psyllium bulking agent: A pilot study

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