Testing control of radiationinduced diarrhea with a psyllium bulking agent: A pilot study

Murphy, Joseph R.; Stacey, Dawn; Crook, Juanita; Thompson, B. S.; Panetta, D

doi:10.5737/1181912x10396100

Cited by 38 publications

(34 citation statements)

References 17 publications

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“…Six studies involved alternative medical systems [18][19][20][21][22][23], 14 involved mind body interventions [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], 15 dealt with biologically based therapies [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53], seven involved manipulative and body-based methods [54][55][56][57][58][59][60], and two energy therapies [61,62]. A large number of scrutinized studies (overall 495) were not included in the final selection as they were not randomized, did not use a PRO measure or the intervention was not among the list of CAM to be included.…”

Section: Resultsmentioning

confidence: 99%

Methodological quality of patient-reported outcome research was low in complementary and alternative medicine in oncology

Efficace

Horneber

Lejeune

et al. 2006

Journal of Clinical Epidemiology

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Section: Resultsmentioning

confidence: 99%

Methodological quality of patient-reported outcome research was low in complementary and alternative medicine in oncology

Efficace

Horneber

Lejeune

et al. 2006

Journal of Clinical Epidemiology

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“…However, to the best of our knowledge, no details are known about the possible underlying mechanism(s), responsible for its medicinal use in constipation, except a preliminary report [25], and a general understanding that its effectiveness in constipation is attributed to its high fiber and mucilaginous content. Similarly, there are some reports validating the medicinal use of psyllium husk in the treatment of diarrhea [26][27][28][29], but no evidence is available explaining the mode of action of its antidiarrheal effect.…”

Section: Introductionmentioning

confidence: 93%

Pharmacological Basis for the Medicinal Use of Psyllium Husk (Ispaghula) in Constipation and Diarrhea

et al. 2010

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This study demonstrates that Ispaghula has a gut-stimulatory effect, mediated partially by muscarinic and 5-HT(4) receptor activation, which may complement the laxative effect of its fiber content, and a gut-inhibitory activity possibly mediated by blockade of Ca(2+) channels and activation of NO-cyclic guanosine monophosphate pathways. This may explain its medicinal use in diarrhea. It is, perhaps, also intended by nature to offset an excessive stimulant effect.

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“…Supplementation with another potential preventative probiotic, Lactobacillus acidophilus , significantly reduced diarrhea in 1748 patients following radiation to the pelvis [136]. In addition, to reduce radiation-induced diarrhea, psyllium fiber supplementation is helpful [137, 138]. …”

Section: Management For Nutrition-related Complicationsmentioning

confidence: 99%

Protein calorie malnutrition, nutritional intervention and personalized cancer care

et al. 2017

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Cancer patients often experience weight loss caused by protein calorie malnutrition (PCM) during the course of the disease or treatment. PCM is expressed as severe if the patient has two or more of the following characteristics: obvious significant muscle wasting, loss of subcutaneous fat; nutritional intake of <50% of recommended intake for 2 weeks or more; bedridden or otherwise significantly reduced functional capacity; weight loss of >2% in 1 week, 5% in 1 month, or 7.5% in 3 months. Cancer anorexiacachexia syndrome (CACS) is a multifactorial condition of advanced PCM associated with underlying illness (in this case cancer) and is characterized by loss of muscle with or without loss of fat mass. Cachexia is defined as weight loss of more than 5% of body weight in 12 months or less in the presence of chronic disease. Hence with a chronic illness on board even a small amount of weight loss can open the door to cachexia. These nutritional challenges can lead to severe morbidity and mortality in cancer patients. In the clinic, the application of personalized medicine and the ability to withstand the toxic effects of anti-cancer therapies can be optimized when the patient is in nutritional homeostasis and is free of anorexia and cachexia. Routine assessment of nutritional status and appropriate intervention are essential components of the effort to alleviate effects of malnutrition on quality of life and survival of patients.

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Testing control of radiationinduced diarrhea with a psyllium bulking agent: A pilot study

Abstract: •

Cited by 38 publications

References 17 publications

Methodological quality of patient-reported outcome research was low in complementary and alternative medicine in oncology

Methodological quality of patient-reported outcome research was low in complementary and alternative medicine in oncology

Pharmacological Basis for the Medicinal Use of Psyllium Husk (Ispaghula) in Constipation and Diarrhea

Protein calorie malnutrition, nutritional intervention and personalized cancer care

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