Effect of a lipid-enriched diet on body composition and some regulatory hormones of food intake in growing rats

Ebal, E.; Cavalié, H.; Michaux, O.; Lac, G.

doi:10.1016/j.ando.2007.06.026

Cited by 8 publications

(3 citation statements)

References 42 publications

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“…As shown before, these two parameters are lower in L than in S rats. We have already discussed this point for LBM in a previous paper [ 11 ]. For bone, other studies have pointed the major role of a correct glucido-protidic intake for an optimal development [ 5 , 12 - 14 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density

Lac¹,

Cavalié²,

Ebal³

et al. 2008

Lipids Health Dis

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In this study, we investigated some bone parameters (bone mineral content, bone mineral density, skeleton area) in growing rats fed with a high fat diet. Correlations between bone and body composition parameters are reported. Two groups of Wistar male rats (35 days old, body mass 80 ± 6 g) were used. Water and food were given "ad libitum" during 10 weeks. Sixteen rats (L) were given a lipid enriched diet and were compared to 16 rats (S) fed with a standard diet. Body composition and bone parameters were assessed using DXA. Results indicated that L rats had lower body mass, lean body mass; fat mass was not different between the two groups. Bone mineral content, bone mineral density, skeleton area of L rats were lower compared with S rats. Significant correlations were noted between body composition, adiponectin and bone parameters. High fat diet intake during the growing period has deleterious effects on bone parameters in rats. This study confirms in growing rats that a high fat diet is pathogenic, including bone metabolism.

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Section: Discussionmentioning

confidence: 99%

Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density

Lac¹,

Cavalié²,

Ebal³

et al. 2008

Lipids Health Dis

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show abstract

“…This pattern of weight curve could be related to a spontaneous low food intake triggered by the peculiarities of the high-fat cafeteria diet and the development of diarrhea after intervention with pioglitazone. The lipid-enriched diet has been associated with hypophagia by various mechanisms, including delayed gastric emptying (33), increased oxidation of lipids (33,34), and increased secretion of cholecystokinin by the pancreas (35). Additionally, pioglitazone is related to the onset of nausea and diarrhea as adverse effects (36), reducing even more food intake.…”

Section: Discussionmentioning

confidence: 99%

A study on the short-term effect of cafeteria diet and pioglitazone on insulin resistance and serum levels of adiponectin and ghrelin

Colombo

Bazzo

Nogueira

et al. 2012

Braz J Med Biol Res

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The interaction between ghrelin and adiponectin is still controversial. We investigated the effect of cafeteria diet and pioglitazone on body weight, insulin resistance, and adiponectin/ghrelin levels in an experimental study on male Wistar rats. The animals were divided into four groups of 6 rats each, and received balanced chow with saline (CHOW-O) or pioglitazone (CHOW-P), or a cafeteria diet with saline (CAFE-O) or pioglitazone (CAFE-P). The chow/cafeteria diets were administered for 35 days, and saline/pioglitazone (10 mg·kg body weight -1 ·day -1 ) was added in the last 14 days prior to euthanasia. CAFE-O animals had a higher mean final weight (372.5 ± 21.01 g) than CHOW-O (317.66 ± 25.11 g, P = 0.017) and CHOW-P (322.66 ± 28.42 g, P = 0.035) animals. Serum adiponectin levels were significantly higher in CHOW-P (55.91 ± 20.62 ng/mL) than in CHOW-O (30.52 ± 6.97 ng/mL, P = 0.014) and CAFE-O (32.54 ± 9.03 ng/mL, P = 0.027) but not in CAFE-P. Higher total serum ghrelin levels were observed in CAFE-P compared to CHOW-P animals (1.65 ± 0.69 vs 0.65 ± 0.36 ng/mL, P = 0.006). Likewise, acylated ghrelin levels were higher in CAFE-P (471.52 ± 195.09 pg/mL) than in CHOW-P (193.01 ± 87.61 pg/mL, P = 0.009) and CAFE-O (259.44 ± 86.36 pg/mL, P = 0.047) animals. In conclusion, a cafeteria diet can lead to a significant weight gain. Although CAFE-P animals exhibited higher ghrelin levels, this was probably related to food deprivation rather than to a direct pharmacological effect, possibly attenuating the increase in adiponectin levels.

show abstract

“…This pattern of weight curve could be related to a spontaneous low food intake triggered by the peculiarities of the high-fat cafeteria diet and the development of diarrhea after intervention with pioglitazone. The lipid-enriched diet has been associated with hypophagia by various mechanisms, including delayed gastric emptying ( 33 ), increased oxidation of lipids ( 33 , 34 ), and increased secretion of cholecystokinin by the pancreas ( 35 ). Additionally, pioglitazone is related to the onset of nausea and diarrhea as adverse effects ( 36 ), reducing even more food intake.…”

Section: Discussionmentioning

confidence: 99%

A study on the short-term effect of cafeteria diet and pioglitazone on insulin resistance and serum levels of adiponectin and ghrelin

Colombo¹,

Bazzo²,

Nogueira³

et al. 2012

Braz J Med Biol Res

View full text Add to dashboard Cite

The interaction between ghrelin and adiponectin is still controversial. We investigated the effect of cafeteria diet and pioglitazone on body weight, insulin resistance, and adiponectin/ghrelin levels in an experimental study on male Wistar rats. The animals were divided into four groups of 6 rats each, and received balanced chow with saline (CHOW-O) or pioglitazone (CHOW-P), or a cafeteria diet with saline (CAFE-O) or pioglitazone (CAFE-P). The chow/cafeteria diets were administered for 35 days, and saline/pioglitazone (10 mg·kg body weight−1·day−1) was added in the last 14 days prior to euthanasia. CAFE-O animals had a higher mean final weight (372.5 ± 21.01 g) than CHOW-O (317.66 ± 25.11 g, P = 0.017) and CHOW-P (322.66 ± 28.42 g, P = 0.035) animals. Serum adiponectin levels were significantly higher in CHOW-P (55.91 ± 20.62 ng/mL) than in CHOW-O (30.52 ± 6.97 ng/mL, P = 0.014) and CAFE-O (32.54 ± 9.03 ng/mL, P = 0.027) but not in CAFE-P. Higher total serum ghrelin levels were observed in CAFE-P compared to CHOW-P animals (1.65 ± 0.69 vs 0.65 ± 0.36 ng/mL, P = 0.006). Likewise, acylated ghrelin levels were higher in CAFE-P (471.52 ± 195.09 pg/mL) than in CHOW-P (193.01 ± 87.61 pg/mL, P = 0.009) and CAFE-O (259.44 ± 86.36 pg/mL, P = 0.047) animals. In conclusion, a cafeteria diet can lead to a significant weight gain. Although CAFE-P animals exhibited higher ghrelin levels, this was probably related to food deprivation rather than to a direct pharmacological effect, possibly attenuating the increase in adiponectin levels.

show abstract

Effect of a lipid-enriched diet on body composition and some regulatory hormones of food intake in growing rats

Cited by 8 publications

References 42 publications

Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density

Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density

A study on the short-term effect of cafeteria diet and pioglitazone on insulin resistance and serum levels of adiponectin and ghrelin

A study on the short-term effect of cafeteria diet and pioglitazone on insulin resistance and serum levels of adiponectin and ghrelin

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