Effect of a lactobacillus preparation on the absorption of oral ampicillin

Abstract

Lactobacillus preparations have been demonstrated to be beneficial in the prevention of antibiotic-associated diarrhea resulting from ampicillin. Since the bioavailability of oral ampicillin is known to be affected by food and fluid volume, a study to evaluate the infuence of a lactobacillus product on ampicillin bioavailability was performed. Twelve healthy volunteers, male and female, were studied in a randomized three-way cross-over study. Each received ampicillin alone, ampicillin with a lactobacillus preparation, and ampicillin followed 1 h later by the lactobacillus preparation. Blood was sampled over a 6-h time period. Ampicillin content was determined by high-pressure liquid chromatography. Area under the concentration-time curve, area under the first moment of the concentration-time curve, maximum concentration of drug in plasma, time to maximum concentration of drug in plasma, and mean residence time were determined for each study interval. No differences in maximum concentration of drug in plasma, time to maximum concentration of drug in plasma, area under the concentration-time curve, or mean residence time were seen for either males or females or the combined group. The lactobacillus preparation as used in this study did not appear to interfere with the bioavailability of oral ampicillin.

Role of Lactobacillus in the Prevention of Antibiotic‐Associated Diarrhea: A Meta‐analysis

“…Fifty-six were unrelated or nonrandomized controlled trials or used non- Lactobacillus regimens. Ten trials were excluded because they included a combination probiotic regimen, [15][16][17][18][19][20] did not assess AAD outcome, 21 were performed in vitro, 22,23 or included a prebiotic regimen. 24 Three studies were excluded because they were not placebo-controlled trials 25,26 or did not specify if antibiotics were used.…”

Bioavailability of oral penicillins in the horse: a comparison of pivampicillin and amoxicillin

“…The fear of inducing dysbacteriosis also applies to oral penicillins. Pseudomembra-nous colitis after oral administration of antibiotics, including ampicillin, is a well-known phenomenon in humans ( Yost & Gotz, 1985) and guinea pigs (De Somer et al, 1955). I n horses, treatment with broad-spectrum antibiotics may cause a serious syndrome commonly known as colitis X (Cook, 1973 & Prior (1982) have shown that diarrhoea caused by antibiotic therapy is accompanied by changes in the faecal flora.…”

Ampicillin-Ester Bonded Branched Polymers: Characterization, Cyto-, Genotoxicity and Controlled Drug-Release Behaviour

“…Ampicillin is absorbed only partially after oral administration and ordinarily about 50% of active compound is extracted in urine [1]. Ampicillin therapy is often accompanied by some gastrointestinal complications such as diarrhoea, vomiting and nausea because of the low solubility of the drug in lipid membranes [2]. Furthermore, ampicillin like other β-lactams, crosses the cell membrane very slowly and it’s unable to reach therapeutic concentrations at the site of infection [3,4].…”