Effect of a Free Sulphydryl Group on Expression of HLA-B27 Specificity

Archer, J. R.; Whelan, Mike; Badakere, S S; McLEAN, I. L.; Archer, Ian; Winrow, V R

doi:10.3109/03009749009097057

Cited by 17 publications

(4 citation statements)

References 18 publications

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“…30 Although the B27 crystal structure suggests that the sulphydryl side chain would be buried beneath processed antigenic peptide,'3 Benjamin et al have evidence that a high proportion of cell surface B27 molecules lack bound peptide.3' Thus even if the crystallographic structure accurately reflects B27 in vivo, a proportion of sulphydryl sites would be accessible.…”

Section: Receptor Modelmentioning

confidence: 99%

HLA-B27 subtypes: implications for the spondyloarthropathies.

MacLean¹

1992

Annals of the Rheumatic Diseases

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Section: Receptor Modelmentioning

confidence: 99%

HLA-B27 subtypes: implications for the spondyloarthropathies.

MacLean¹

1992

Annals of the Rheumatic Diseases

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“…Frequencies of allelic groups of human leukocyte antigen-DRB1*, HLA-DRB3*, HLA-DRB4*, HLA-DRB5* and human leukocyte antigen-DQB1* gene locus in control group 1 This variant of genotype can be considered a predisposing factor for the development of RA. Its increased frequency was the result of the presence of allelic group HLA-DRB1*01, in which higher frequency in RA patients was established ( Table 6).…”

Section: Resultsmentioning

confidence: 99%

“…1 This theory of connection between RA and DRB1 gene with a common epitope includes approximately 80% of populations in the northern Europe, while this connection occurs in only 43% of Greek patients. 3 The results obtained for HLA class II polymorphisms in RA patients in Federation of Bosnia and Herzegovina (FB&H) point to the role of allelic groups DRB1*01 (OR=2.795) and DRB1*04 (relative risk=2.573) in susceptibility to this disease.…”

Section: Discussionmentioning

confidence: 99%

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Crosslinks Between Human Leukocyte Antigen DRB101 and Human Leukocyte Antigen DRB113 Allelic Variants and Occurrence of Rheumatoid Arthritis in Patients From Federation of Bosnia and Herzegovina

et al. 2017

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Objectives:This study aims to analyze human leukocyte antigen A (HLA-A), human leukocyte antigen B (HLA-B), human leukocyte antigen C (HLA-C), HLA-DRB1*, HLA-DRB3*, HLA-DRB4*, HLA-DRB5*, HLA-DQB1* loci expression in patients with rheumatoid arthritis (RA) in the Federation of Bosnia and Herzegovina. Patients and methods: Deoxyribonucleic acid was isolated from peripheral blood of 48 RA patients (22 males, 26 females; mean age 36 years; range 2 to 63 years) and 104 healthy control individuals (52 males, 52 females; mean age 43 years; range 2 to 76 years). Deoxyribonucleic acid samples were analyzed using polymerase chain reaction-sequence-specific primers and sequence specific oligonucleotides methods. Results:The most frequent allelic groups in RA patients were HLA-DRB1*01 (odds ratio=2.795; 95% confidence interval: 1.441-5.421; p=0.004) and HLA-DRB1*04 (odds ratio=2.573; 95% confidence interval: 1.214-5.453; p=0.023). Among RA patients, the most frequent genotype for the allelic group HLA-DRB1*, in the light of the common epitopes theory, was observed for DRB1*01/DRB1*13. This genotype indicates an increased incidence and relative risk (odds ratio=11.09). Conclusion:The most common genotype in our RA patients was DRB1*01/DRB1*13, which showed increased frequency and a high relative risk. This genotype variant may be considered a predisposing factor for the development of RA.

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