Effect of a Controlled‐Release Chlorhexidine Chip on Clinical and Microbiological Parameters and Prostaglandin E₂ Levels in Gingival Crevicular Fluid

Abstract

Based on the findings of this study, the chlorhexidine chip reduced GCF PGE2 levels and had positive effects on clinical parameters and subgingival flora when used as adjunctive therapy to SRP in patients with chronic periodontitis.

Adjunctive Effects of A Piscean Collagen-Based Controlled-Release Chlorhexidine Chip in the Treatment of Chronic Periodontitis: A Clinical and Microbiological Study

“…Plaque levels were similarly low after completion of the hygiene phase and were maintained throughout the study, thus indicating good compliance by all patients. Interestingly, significant reduction of plaque scores in the SRP plus CHX group was seen, which was comparable to the results obtained by Mizrak et al, [13] and Rodrigues IF et al, [35] with PerioChip. As demonstrated by Patrick Adriaens et al, [36], professional plaque control reduced microbial counts of both supra and subgingival plaque.…”

“…As demonstrated by Patrick Adriaens et al, [36], professional plaque control reduced microbial counts of both supra and subgingival plaque. Subgingival Chlorhexidine has also shown to reduce crevicular PGE 2 [13] and crevicular MMP-8 [14], which may explain the resolution of Inflammation [33,37]. In the present study, the ability of subgingivally delivered chlorhexidine helped to significantly reduce gingival index scores in the test group [17][18][19][20].…”

“…Conflicting studies reported little benefit of reduction in microorganisms over SRP [5,10,11], whereas other studies reported significant benefit of SRP plus CHX chip treatment over SRP alone on the subgingival micro biota, an effect which diminished over time [12][13][14]. Local drug delivery has provided a plethora of treatment options, one among this is the recent introduction of Periocol CG -A new biodegradable collagenbased CHX chip (Periocol-CGTM, Eucare pharmaceuticals, Chennai, India) derived from fresh-water fish Collagen, which is a natural protein, non-allergenic, and known to be chemo tactic to fibroblasts [15,16] in a fish collagen matrix.…”

“…The antimicrobial benefit of this collagen-based chip is comparable with the microbiological studies of PerioChip. Mizrak et al, [13] showed that a significant reduction occurs in the percentage of subgingival spirochetes when chlorhexidine chips were placed. This is the first of its kind report of microbiological analysis of Periocol CG and hence the results cannot be compared with the same drug delivery agent.…”

Biocompatibility of a chlorhexidine local delivery system in a subcutaneous mouse model

“…Local administration, therefore, may be considered an alternative to overcome these problems. Improved patient compliance, drug access to the site of disease, and lower total drug dosage are the main benefits of a controlled delivery device (5). A degradable, subgingivally placed drug delivery system containing 2.5 mg chlorhexidine gluconate ‡ was developed(6), but experimental and clinical studies demonstrated controversial results about the use of CHX chip as an adjunct of SRP in the treatment of periodontal disease (3)(4)(5)(6)(7)(8)(9)(10).…”