Effect of a compound based on an aqueous solution of fullerene C60 on hematological parameters of white rats

Abstract

The article is devoted to the study of the effect of a compound based on an aqueous solution of fullerene C60 on the hematological parameters of white rats. The experiment was carried out on three groups of animals. The first group served as a control. The second group was injected with 1 ml of an aqueous solution of Fullerene C60 (1 mg / ml of DV), 150 mg of resveratrol – 25 mg, betoin hydrochloride – 10 mg. The third group received 1 ml of an aqueous solution of Fullerene C60 (1 mg/ml of DV), 2500 mg of resveratrol, 1000 mg of betoin hydrochloride. It was determined that the animals of the second group had a significant increase in the number of erythrocytes by 11.8% and the hemoglobin content by 14.8% relative to the control values. In white rats of the third group, there were no significant differences with the control. In animals of the second group, the number of rod-shaped neutrophils and monocytes increased by 10 and 9.3%, respectively, relative to the control. No significant differences were found in animals of the third group. The number of segmented neutrophils after the introduction of an aqueous solution of fullerene C60 increased by 12.4% (group 2 animals) and 6.1% (group 3 animals). It was revealed that the compound based on an aqueous solution of fullerene C60 has a pronounced effect on the hematological parameters of the body of white rats. The most effective dose was 1 ml of an aqueous solution of Fullerene C60 (1 mg / ml of DV), 150 mg of resveratrol – 25 mg, betoin hydrochloride – 10 mg, after administration of which an increase in the number of erythrocytes by 11.8% and the hemoglobin content by 14.8% relative to the control values, the number of rod-shaped neutrophils and monocytes by 10 and 9.3%, respectively, and the number of segmented neutrophils by 12.4%.