Effect of a 5-lipoxygenase inhibitor, AL-3264, on propranolol-induced bronchoconstriction in guinea-pigs

Songur, Nejla; Fujimura, Masaki; Mizuhashi, Keiichi; Saito, Motoyasu; Myou, Shigeharu; Kamio, Yumie; Matsuda, Tamotsu

doi:10.1016/0929-7855(94)00036-c

Cited by 9 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Together with our previous study on thromboxane A 2 [5] and 5-lipoxygenase [11], the present study confirms that a mediator mechanism resulting from the antigen/ antibody reaction is important in the pathophysiology of propranolol-induced bronchoconstriction. However, further clinical studies are needed using specific antagonists of lipid mediators to clarify whether the mediator mechanisms are relevant to clinical asthma.…”

Section: Discussionsupporting

confidence: 89%

“…Our previous study [5] revealed that TxA 2 may also play an important role in the pathogenesis of this reaction. In addition, a recent preliminary study from our group [11] showed that a 5-lipoxygenase inhibitor, AL3264, inhibited the PIB developed after allergic reaction, leading us to examine the role of another lipid mediator, PAF, in the PIB. This study clearly showed that PAF is involved in the PIB.…”

Section: Discussionmentioning

confidence: 99%

“…Histamine was found to be involved in the PIB in asthmatic patients [10]. Our previous studies [5,11] showed that thromboxane A 2 and 5-lipoxygenase products are important in the PIB. These findings suggest that inflammatory mediators contribute to the development of PIB.…”

mentioning

confidence: 93%

See 2 more Smart Citations

Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs

Fujimura

Tsujiura²,

Songur³

et al. 1996

Eur Respir J

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs

Fujimura

Tsujiura²,

Songur³

et al. 1996

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…Our previous study 15] revealed that thromboxane Ai also may play an important role in the pathogenesis of this reaction. In addition, our preliminary study [10] showed that a 5-lipoxygenase inhibitor. AL3264.…”

Section: Discussionmentioning

confidence: 92%

“…Histamine was found to be involved in the PIB in asthmatic patients [9]. Our previous studies [5,10] showed that thromboxane AT and 5-lipoxygenase products are important in the PIB. These findings suggest that inflammatory mediators contribute to the development of PIB.…”

Section: Introductionmentioning

confidence: 99%

Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo

Fujimura¹,

Tsujiura²,

Myou³

et al. 1996

Clin Exp Allergy

View full text Add to dashboard Cite

show abstract

Based on UHPLC–Q‐TOF–MS and bioinformatics strategies, the potential allergens and mechanisms of allergic reactions caused by Danshen injection were explored

Lei,

Zhiqi,

You

et al. 2024

Biomedical Chromatography

View full text Add to dashboard Cite

The aim is to investigate the potential allergens and mechanisms underlying allergic‐like reactions induced by Danshen injection (DSI). Utilizing ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry (UHPLC–Q‐TOF–MS), metabolomics, and bioinformatics, we identified the key allergens, targets, and metabolic pathways involved in DSI‐induced allergic‐like reactions, validating binding efficiency through molecular docking and molecular dynamics. A total of 45 compounds were identified within DSI, with 24 compounds exhibiting strong binding activity to the MrgprX2 activation site. DSI was found to cause changes in 89 endogenous metabolites, including arachidonic acid, prostaglandins, and leukotrienes, primarily affecting pathways such as phenylalanine metabolism and arachidonic acid metabolism. The key allergens identified were Cryptotanshinone, Miltipolone, Neocryptotanshinone, Salvianolic acid B, and Isosalvianolic acid C, which primarily trigger allergic‐like reactions by regulating upstream signaling targets such as ALOX5, PTGS1, PPARD, and LTB4R. Validation confirmed the high binding affinity and stability between key allergens and targets. These findings indicate that the allergic components in DSI primarily induce allergic‐like reactions by modulating the aforementioned signaling targets, activating the AA metabolic pathway, promoting mast cell degranulation, and releasing downstream endogenous inflammatory mediators, subsequently eliciting allergic‐like reactions.

show abstract

Effect of a 5-lipoxygenase inhibitor, AL-3264, on propranolol-induced bronchoconstriction in guinea-pigs

Cited by 9 publications

References 24 publications

Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs

Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs

Role of sensory neuropeptides in post-allergic propranolol-induced bronchoconstriction in guinea pigs in vivo

Based on UHPLC–Q‐TOF–MS and bioinformatics strategies, the potential allergens and mechanisms of allergic reactions caused by Danshen injection were explored

Contact Info

Product

Resources

About